Direct and Derivative Spectrophotometric Determination of Zn(II) in Pharmaceuticals

Abstract

Heterocyclic compound diamino and dihydroxy-pyramidine was synthesized and proposed as chelating agent for the determination of trace amounts of zinc. Zinc(II) forms the ripen-mangocolour complex with DADHP (Diamino dihydroxypyrimidine) in 1:3 stoichiometric ratio at pH-6 in acetic acid and sodium acetate buffer in the presence of pyrideniumchloride as salting out agent. The maximum absorbance is observed at 480 nm. The Beer's law is obeyed in the range of 1-6 µg. The molar absorptivity (ε) and Sandell's sensitivity of the complex is 0.1484 x 10 4 L mol-1 cm-1 and 0.04545 µg cm-1 respectively. The method was successfully applied for the quantification of Zn(II) in pharmaceutical multi vitamin preparations in the presence of other trace elements. The statistical data evaluated reveals the sensitivity and accuracy of the method than the other methods reported.

Development of Method for Extractive Spectrophotometric Determination of Zn (II) with of 2-[2-(4-CHLORO BENZOTHIOZOLE)IMINO]-5- NITRO PHENOL as an Analyticalreagent

“…Spectroscopy is an important technique for a trace analysis of element and it is one of the most powerful tools in chemical analysis. There are numerous methods for the spectrophotometric determination of zinc at trace level [11][12][13][14][15][16]. The present investigation 2-[2-(4-Chloro Benzothiozole) imino] -5 -Nitro Phenol (CBZTINP) is used for the first time as an analytical reagent for the spectrophotometric determination of zinc (II) at trace levels.…”