Direct and Indirect Antioxidant Activity of Polyphenol- and Isothiocyanate-Enriched Fractions from<i>Moringa oleifera</i>

Tumer, Tugba Boyunegmez; Rojas-Silva, Patricio; Poulev, Alexander; Raskin, Ilya; Waterman, Carrie

doi:10.1021/jf505014n

Cited by 122 publications

(78 citation statements)

References 43 publications

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“…In our study, dietary MOL decreased serum MDA. Previous studies demonstrated that the MOL possessed potent antioxidant properties due to its high contents of phenolic compounds and isothiocyanate (Tumer, Rojas-Silva, Poulev, Raskin, & Waterman, 2015;Verma et al, 2009). Additionally, Moringa oleifera leaf and fruit extracts were found to reduce MDA levels both in vitro and in vivo (Luqman, Srivastava, Kumar, KumarMaurya, & Chanda, 2012).…”

Section: Discussionmentioning

confidence: 99%

The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

Zeng

Luo

Wang

et al. 2019

Food Science & Nutrition

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Moringa oleifera is a tropical plant with high nutritional and medicinal value. Recent studies have reported its remarkable effects in inflammatory, antioxidative, and anti‐diabetes modulations, but there was no significant report on its role in animal breeding. In this study, we investigated the effects of dietary Moringa oleifera leaf (MOL) on reproductive performances in mice. We studied the reproductive performance of mice for six consecutive gestations. Mice fed with 4% MOL diet showed improved litter size, litter birth weight, and litter survivals until weaning age compared to control mice fed with normal diet (p < 0.05). Mice fed with MOL diet did not change weight and organ coefficients. Serum malondialdehyde (MDA) concentrations in both male and female mice were significantly decreased by dietary MOL (p < 0.05), but glutathione peroxidase (GSH‐PX) and superoxide dismutase (SOD) were unchanged. For male, dietary MOL significantly reduced sperm abnormality rate (p < 0.05) and Bcl2‐associated X protein (Bax) expression in testis (p < 0.05), but did not affect serum testosterone and the expression levels of androgen receptor (AR), phosphoglycerate kinase 2 (Pgk2), protamine2 (Prm2), and B cell leukemia/lymphoma 2 (Bcl2) in testis. For female, dietary MOL did not change serum estradiol and the expressions of estrogen receptor beta (ERβ), Bcl2, Bax, and vascular endothelial growth factor receptor (VEGFR) in ovary. In summary, MOL increased litter size and antioxidant ability, reduced the rate of sperm abnormality and the expression of Bax. Therefore, MOL may serve as a functional feed addictive for improving animal reproductive performance.

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Section: Discussionmentioning

confidence: 99%

The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

Zeng

Luo

Wang

et al. 2019

Food Science & Nutrition

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“…Either the direct action of antioxidants which are usually small molecules that directly clean up reactive oxygen species (ROS) or nitrogen species, or the indirect action of antioxidants which acts through the activation of phase II metabolic enzymes (such as glutathione S-transferase, aldehide reductase etc.) (Dinkova-Kostova and Talalay 2008;Tumer et al 2015). Thus, glucosinolates and isothiocyanates are considered as indirect antioxidants, because they trigger the transcription of phase II metabolic enzymes (Ishida et al 2014;Vig et al 2009;Cartea González et al 2008;Fuentes et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis and bioactivity of glucosinolates and their production in plant in vitro cultures

Sánchez-Pujante

Borja-Martínez

Pedreño

et al. 2017

Planta

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Main conclusion Glucosinolates are biologically active compounds which are involved in plant defense reaction. The use of plant in vitro cultures and genetic engineering is a promising strategy for their sustainable production.Glucosinolates are a class of secondary metabolites found mainly in Brassicaceae, which contain nitrogen and sulfur in their structures. Glucosinolates are divided into three groups depending on the amino acid from which they are biosynthesized. Aliphatic glucosinolates are generally derived from leucine, valine, methionine, isoleucine and alanine while indole and aromatic glucosinolates are derived from tryptophan and phenylalanine or tyrosine, respectively. These compounds are hydrolyzed by the enzyme myrosinase when plants are stressed by biotic and abiotic factors, obtaining different degradation products. Glucosinolates and their hydrolysis products play an important role in plant defense responses against different types of stresses. In addition, these compounds have beneficial effect on human health because they are strong antioxidants and they have potent cardiovascular, antidiabetic, antimicrobial and antitumoral activities. Due to all the properties described above, the demand for glucosinolates and their hydrolysis products has enormously increased, and therefore, new strategies that allow the production of these compounds to be improved are needed. The use of plant in vitro cultures is emerging as a biotechnological strategy to obtain glucosinolates and their derivatives. This work is focused on the biosynthesis of glucosinolates and the bioactivity of these compounds in plants. In addition, a detailed study on the strategies used to increase the production of several glucosinolates, in particular those synthesized in Brassicaceae, using in vitro plant cultures has been made. Special attention has been paid for increasing the production of glucosinolates and their derivatives using metabolic engineering.

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“…Leaf powder capsules (4 g) considerably improved the discharge of insulin in 10 healthy human volunteers (Anthanont, Lumlerdkij, Akarasereenont, Vannasaeng, & Sriwijitkamol, ). 4‐[(α‐ l ‐rhamnosyloxy)benzyl] isothiocyanate and 4‐[(4′‐O‐acetyl‐α‐ l ‐rhamnosyloxy)benzyl] isothiocyanate showed antidiabetic activity (Tumer et al, ; Waterman et al, ). In alloxan‐induced diabetic rats, the aqueous extract (300 mg/kg) exhibited 44.06% reduction respectively of blood glucose concentration within 6 hr of administration, whereas almost as effective as the standard drug tolbutamide (200 mg/kg,) caused 46.75% reduction (Edoga, Njoku, Amadi, & Okeke, ).…”

Section: Resultsmentioning

confidence: 99%

“…MO tree contains about 40 natural antioxidants (Mahmood et al, ). The antioxidant activity is attributed due to the presence of various types of antioxidant compounds (Omodanisi et al, ; Siddhuraju & Becker, ) such as ascorbic acid, β‐carotene (Kumar, Pandey, Mohan, & Singh, ; Mahajan & Mehta, ), quercetin, kaempferol (Gupta et al, ), flavonoids, phenolics (Anwar, Ashraf, & Bhanger, ; Sreelatha et al, ), isothiocyanates, polyphenols, and rutin in leaves (Tumer et al, ); myricetin (Lalas & Tsaknis, ), tocopherols and lectins in seeds (Singh et al, ); procyanidins in stem and root bark (Atawodi et al, ) and palmitic acid, phytosterols, and 9‐octadecenamide in flowers (Inbathamizh & Padmini, ), monopalmitic acid, oleic acid, tri‐oleic triglycerides in seed oil (Lalas & Tsaknis, ; Mahajan & Mehta, ). Methanol and acetone extracts of leaves (Atawodi et al, ; Charoensin, ), aqueous extracts of roots (Satish, Kumar, Rakshith, Satish, & Ahmed, ), methanolic extracts of stem and pods (Gupta et al, ; Kumbhare, Guleha, & Sivakumar, ) showed wide antioxidant profile.…”

Section: Resultsmentioning

confidence: 99%

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

Dhakad

Ikram

Sharma

et al. 2019

Phytotherapy Research

178

100

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The genus Moringa Adans. comprises 13 species, of which Moringa oleifera Lam. native to India and cultivated across the world owing to its drought and frost resistance habit is widely used in traditional phytomedicine and as rich source of essential nutrients. Wide spectrum of phytochemical ingredients among leaf, flower, fruit, seed, seed oil, bark, and root depend on cultivar, season, and locality. The scientific studies provide insights on the use of M. oleifera with different aqueous, hydroalcoholic, alcoholic, and other organic solvent preparations of different parts for therapeutic activities, that is, antibiocidal, antitumor, antioxidant, anti‐inflammatory, cardio‐protective, hepato‐protective, neuro‐protective, tissue‐protective, and other biological activities with a high degree of safety. A wide variety of alkaloid and sterol, polyphenols and phenolic acids, fatty acids, flavanoids and flavanol glycosides, glucosinolate and isothiocyanate, terpene, anthocyanins etc. are believed to be responsible for the pragmatic effects. Seeds are used with a view of low‐cost biosorbent and coagulant agent for the removal of metals and microbial contamination from waste water. Thus, the present review explores the use of M. oleifera across disciplines for its prominent bioactive ingredients, nutraceutical, therapeutic uses and deals with agricultural, veterinarian, biosorbent, coagulation, biodiesel, and other industrial properties of this “Miracle Tree.”

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Direct and Indirect Antioxidant Activity of Polyphenol- and Isothiocyanate-Enriched Fractions fromMoringa oleifera

Cited by 122 publications

References 43 publications

The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

The beneficial effects of Moringa oleifera leaf on reproductive performance in mice

Biosynthesis and bioactivity of glucosinolates and their production in plant in vitro cultures

Biological, nutritional, and therapeutic significance of Moringa oleifera Lam

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