Direct and indirect costs of nephrolithiasis in an employed population: Opportunity for disease management?

Saigal, Christopher S.; Joyce, Geoffrey F.; Timilsina, Anga R.

doi:10.1111/j.1523-1755.2005.00599.x

Cited by 397 publications

(245 citation statements)

References 14 publications

(8 reference statements)

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“…Recurrences are common, because approximately 25% of untreated patients experience a new episode within 5 years (2). In addition to the pain and suffering, the medical costs associated with kidney stones exceed $2 billion annually, and there are additional costs because of missed work (3,4).…”

Section: Introductionmentioning

confidence: 99%

Soda and Other Beverages and the Risk of Kidney Stones

Ferraro

Taylor

Gambaro

et al. 2013

Clinical Journal of the American Society of Nephrology

226

181

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SummaryBackground and objectives Not all fluids may be equally beneficial for reducing the risk of kidney stones. In particular, it is not clear whether sugar and artificially sweetened soda increase the risk.Design, setting, participants, & measurements We prospectively analyzed the association between intake of several types of beverages and incidence of kidney stones in three large ongoing cohort studies. Information on consumption of beverages and development of kidney stones was collected by validated questionnaires.Results The analysis involved 194,095 participants; over a median follow-up of more than 8 years, 4462 incident cases occurred. There was a 23% higher risk of developing kidney stones in the highest category of consumption of sugar-sweetened cola compared with the lowest category (P for trend=0.02) and a 33% higher risk of developing kidney stones for sugar-sweetened noncola (P for trend=0.003); there was a marginally significant higher risk of developing kidney stones for artificially sweetened noncola (P for trend=0.05). Also, there was an 18% higher risk for punch (P for trend=0.04) and lower risks of 26% for caffeinated coffee (P for trend,0.001), 16% for decaffeinated coffee (P for trend=0.01), 11% for tea (P for trend=0.02), 31%-33% for wine (P for trend,0.005), 41% for beer (P for trend,0.001), and 12% for orange juice (P for trend=0.004).Conclusions Consumption of sugar-sweetened soda and punch is associated with a higher risk of stone formation, whereas consumption of coffee, tea, beer, wine, and orange juice is associated with a lower risk.

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Section: Introductionmentioning

confidence: 99%

Soda and Other Beverages and the Risk of Kidney Stones

Ferraro

Taylor

Gambaro

et al. 2013

Clinical Journal of the American Society of Nephrology

226

181

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“…[5][6][7][8][9] This results in a heavy economic and social burden. 10,11 An appropriate prevention strategy is urgently needed to reduce the prevalence and health care costs that arise from the condition.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of kidney stones and associated risk factors in the Shunyi District of Beijing

Jiang¹,

Lh²,

Luo³

et al. 2017

Hong Kong Med J

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“…Today, renal stones pose a significant public health problem, with lifetime risk of forming a stone exceeding 5% in women and 12% in men 2 . The direct and indirect costs are substantial, with the annual cost in the United States estimated to be in excess of $5 billion 3 .…”

Section: Introductionmentioning

confidence: 99%

Searching for CYP24A1 mutations in cohorts of patients with calcium nephrolithiasis

Sayers¹,

Hynes²,

Rice³

et al. 2013

OA Nephrology

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IntroductionThe genetics underlying the idiopathic hypercalciuria leading to calciumcontaining renal stones remains elusive. The discovery of rare monogenic tubulopathies, often leading to hypercalciuria, has increased our understanding of tubular physiology and patho-physiology. However, insights into idiopathic calcium stone formation have not been gained from these disorders. The aim of this study is to examine CYP24A1 mutations in cohorts of patients with calcium nephrolithiasis. Materials and MethodsWe examined two cohorts of stoneforming patients for mutations in CYP24A1, which encodes the vitamin D24-hydroxylase enzyme. The first cohort had a biochemical phenotype of suppressed parathyroid hormone and high normal serum calcium, whilst the second cohort had a hypercalciuria phenotype. We did not identify bi-allelic sequence variants in CYP24A1 in our cohorts. ResultsIn cohort 1, we identified 9 known sequence variants. In cohort 2 we identified 7 known sequence variants. Conclusion CYP24A1 mutations remain a rare cause of calcium nephrolithiasis and hypercalciuria.

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Direct and indirect costs of nephrolithiasis in an employed population: Opportunity for disease management?

Abstract: The direct and indirect costs of nephrolithiaisis are substantial among working-age adults. Interventions that prevent recurrence among known stone formers may be a cost-effective component of disease management programs.

Cited by 397 publications

References 14 publications

Soda and Other Beverages and the Risk of Kidney Stones

Soda and Other Beverages and the Risk of Kidney Stones

Prevalence of kidney stones and associated risk factors in the Shunyi District of Beijing

Searching for CYP24A1 mutations in cohorts of patients with calcium nephrolithiasis

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