Direct and indirect effects of leptin on adipocyte metabolism

Harris, Ruth B. S.

doi:10.1016/j.bbadis.2013.05.009

Cited by 254 publications

(189 citation statements)

References 203 publications

(270 reference statements)

Supporting

Mentioning

174

Contrasting

Unclassified

Order By: Relevance

“…Leptin as a hormone is primarily synthesized and secreted by white adipose tissue and was first cloned in 1994 (9). Leptin is primarily involved in the regulation of food intake and energy expenditure (10)(11)(12) and is closely correlated with obesity (13). It has been reported that leptin levels are positively correlated with weight gain (14).…”

Section: Introductionmentioning

confidence: 99%

Leptin promotes the proliferation and migration of human breast cancer through the extracellular-signal regulated kinase pathway

Sun

2013

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. Obesity has been associated with an increased risk of postmenopausal breast cancer, which may be due to the expression of leptin. The aim of this study was to determine the role of leptin in the growth of breast cancer cells in nude mice, the proliferation and migration of MCF-7 human breast cancer cells and its downstream signaling pathway. The xenograft mouse model was elicited by injecting MCF-7 human breast cancer cells into the left back axilla and the tumor size was measured every other day. Leptin injected subcutaneously around the tumor site led to an increase in the size and weight of the tumor, whereas the leptin antagonist (LA) significantly inhibited the size and weight of the tumor. Leptin promoted the proliferation and migration of MCF-7 cells and LA inhibited it. The effects of leptin on increasing the size and weight of the tumor in the nude mice and the proliferation and migration of MCF-7 human breast cancer cells were eradicated by pretreatment with LA, the extracellular-signal regulated kinase (ERK) inhibitor PD98059. In the xenograft mouse model the leptin level was increased and leptin increased the phosphorylation of ERK in the MCF-7 cells, whereas LA significantly reduced the phosphorylation of ERK. These results indicated that leptin promotes the growth of breast cancer in the nude mice and increases the proliferation and migration of MCF-7 human breast cancer cells via the ERK pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Leptin promotes the proliferation and migration of human breast cancer through the extracellular-signal regulated kinase pathway

Sun

2013

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…This finding is controversial since PGE2 is known to enhance leptin secretion by adipocytes (Fain et al, 2000;Harris, 2014). Thus, the observed induction of Leptin mRNA could represent a compensatory response to reduced synthesis of PGE2, or depletion of Angptl8 might affect Leptin expression through another, thus far unknown mechanism.…”

Section: Discussionmentioning

confidence: 78%

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition

Antharaparambat

Mysore

Liebisch³

et al. 2017

Atherosclerosis

View full text Add to dashboard Cite

show abstract

“…These findings raised questions about the true biological role of leptin on lipid mobilization and its activity on fat cells [51]. Furthermore, leptin expression also plays an important role in adipocyte differentiation from preadipocytes to mature adipocytes [52]. Thus far, the origin of BAT is not well understood.…”

Section: Adipocytes and Their Role In Metabolismmentioning

confidence: 94%

Future Perspectives of Metabolomics in Adipocytes

Tadi¹,

Sweeney²,

Tiziani

2014

J Nutr Health Food Sci

View full text Add to dashboard Cite

on their ability to characterize large data sets, these 'omics' techniques will have an impact on our understanding of adipose tissue function (Figure 1) [11]. To date, most of the metabolic studies have focused on monitoring specific biochemical pathways. Until recently, untargeted metabolic profiling has not attained much attention due to its complexity and unavailability of suitable analytical platforms capable of generating and processing large data sets [12,13]. However, implementation of advanced statistical and bioinformatics tools to systems biology is capable of providing the valuable information required for finding solutions to diverse metabolic disorders [14][15][16]. Diversity of adipose tissueIn mammals, fat tissue is classified according to morphological appearance. WAT distribution varies by age, gender, and genetic origin, but is the most abundant regardless of these factors [17]. Unlike white adipocytes, brown adipocytes have an abundance of mitochondria and therefore have very high metabolic turnover. In mice, brown adipose tissue has been identified in the interscapular (iBAT), sub-scapular (sBAT), cervical (cBAT) and neck regions [18,19]. Alternatively in adult humans, BAT is found in the supraclavicular and neck regions [18][19][20]. However, less is known about the origin and metabolic role of BAT. It is known to be more abundant in infants than adults [21]. At the early embryonic stage, very little lipid accumulation occurs in brown adipocytes, but a marked increase has been reported after birth [22]. Although initially BAT was believed to only have a functional role in infants and rodents, later studies have demonstrated its presence in adults, as well as, significant changes in response to mild cold exposure [23]. While WAT is primarily an energy storage site, it also behaves as an endocrine organ by secreting hormones, known as adipokines, which are involved in feeding and metabolic regulation [24]. On the other hand, BAT readily converts triglyceride (TGs) reserves into FAs, an energy source for non-shivering thermogenesis [25][26][27]. This process is mediated by mitochondrial uncoupling protein-1 (UCP-1) present on the inner mitochondrial membrane. UCP-1 depletes the electrochemical gradient across the mitochondrial membrane which channels the available FAs to the production of heat, rather than ATP [25].Recent identification of beige adipocytes has also attracted significant attention [28]. A number of quantitative trait loci are AbstractObesity and diabetes have reached global epidemic status in modern society. It is well known that metabolic syndrome leads to the progression of these diseases, eventually decreasing quality of life. In wake of these epidemics, adipose tissue has attracted significant attention because of its activity as an energy storage reservoir. Lately, even more importance has been given to the different classes of adipocytes including white, brown and beige adipose tissues.Most research has been focused on understanding molecular mechanisms of cellular signal...

show abstract

Direct and indirect effects of leptin on adipocyte metabolism

Cited by 254 publications

References 203 publications

Leptin promotes the proliferation and migration of human breast cancer through the extracellular-signal regulated kinase pathway

Leptin promotes the proliferation and migration of human breast cancer through the extracellular-signal regulated kinase pathway

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition

Future Perspectives of Metabolomics in Adipocytes

Contact Info

Product

Resources

About