Direct and Label‐Free Detection of Solid‐Phase‐Bound Compounds by Using Surface‐Enhanced Raman Scattering Microspectroscopy

Schmuck, Carsten; Wich, Peter; Küstner, Bernd; Kiefer, W.; Schlücker, Sebastian

doi:10.1002/anie.200605190

Cited by 44 publications

(27 citation statements)

References 35 publications

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“…Figure 50 shows schematically how colloidal SERS was used for the direct and label-free detection of an artificial peptide receptor (1), which was bound on the polystyrene surface of a micron-sized bead. [119] Colloidal silver particles with a diameter of roughly 20 nm are added to the surface. Upon resonant laser excitation, only the solid-phase-bound compound 1, which is in close vicinity to the Ag surface, experiences the high near-field enhancement and is observed in the corresponding SERS spectrum.…”

Section: Sers Detection Through External Plasmonic Nanostructuresmentioning

confidence: 99%

Surface‐Enhanced Raman Spectroscopy: Concepts and Chemical Applications

2014

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Surface-enhanced Raman scattering (SERS) has become a mature vibrational spectroscopic technique during the last decades and the number of applications in the chemical, material, and in particular life sciences is rapidly increasing. This Review explains the basic theory of SERS in a brief tutorial and-based on original results from recent research-summarizes fundamental aspects necessary for understanding SERS and provides examples for the preparation of plasmonic nanostructures for SERS. Chemical applications of SERS are the centerpiece of this Review. They cover a broad range of topics such as catalysis and spectroelectrochemistry, single-molecule detection, and (bio)analytical chemistry.

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Section: Sers Detection Through External Plasmonic Nanostructuresmentioning

confidence: 99%

Surface‐Enhanced Raman Spectroscopy: Concepts and Chemical Applications

2014

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“…These materials are characterized by using micrometer‐ or submicrometer‐sized particles to support the enhancing plasmonic nanostructures (see examples in Figure 4). 30–34 The final hybrid materials are thus sufficiently small to behave as colloidal suspensions but are large enough to be observed under a conventional confocal microscope. The deposition of plasmonic nanostructures on their surface can be carried out in different ways, through either direct growth31 or assembly of preformed nanoparticles,32 and usually are aggregated in such a way that they become a dense collection of hot spots.…”

Section: Direct Biomolecule Sensingmentioning

confidence: 99%

Three‐Phase Interlines Electrochemically Driven into Insulator Compounds: A Penetration Model and Its Verification by Electroreduction of Solid AgCl

Xiao¹,

Jin²,

Deng³

et al. 2006

Chemistry A European J

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A dynamic three-phase interline model has been developed for the reduction of a solid insulating metal compound to the metal in a suitable electrolyte, focusing on the electrochemically driven penetration of the process (or the three-phase interlines) into the insulator. Consideration is given to the effects of electrochemical, concentration and ohmic polarizations in the reduction-generated porous metal layer on top of the solid compound. Under potentiostatic conditions, reduction in the depth direction (penetration) becomes progressively slower as a result of the rising ohmic and concentration polarizations, whilst the electrochemical polarization exerts a declining effect. The quantitative equations established here also provide simple methods for the determination of some kinetic parameters of the reduction process, including rho (total resistivity) and D(R) (diffusion coefficient). The model has been experimentally verified by electrochemical reduction of solid AgCl with two novel metal|AgCl cylinder electrodes in aqueous solutions.

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“…Various methods have been developed to prepare SERS substrates for high Raman signal enhancement factors (RS‐EFs), including vapor deposition, chemical reactions, ion‐beam‐sputtered technique, and nanolithography methods . In all nanofabrication methods, sensitivity and reproducibility improvement of SERS substrates are very important.…”

Section: Introductionmentioning

confidence: 99%

“…[16] Ideally, a SERS substrate should enhance the Raman signal sufficiently to enable suitable chemical detection levels while at the same time being easily reproducible [17] on the nanoscale for sensing application. [18][19][20] Various methods have been developed to prepare SERS substrates for high Raman signal enhancement factors (RS-EFs), including vapor deposition, [21] chemical reactions, [22] ion-beamsputtered technique, [23,24] and nanolithography methods. [25][26][27] In all nanofabrication methods, sensitivity and reproducibility improvement of SERS substrates are very important.…”

Section: Introductionmentioning

confidence: 99%

Surface‐enhanced Raman spectroscopy of dye molecules on Ag‐modified silicon nanowire substrates: influence of photoinduced probe degradation on enhancement factors

Mehrvar

Sadeghipari

Tavassoli

et al. 2017

J Raman Spectroscopy

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Photobleaching effect is an immense problem in optical spectroscopy, especially when fluorophores are adsorbed on metal nanoparticles (NPs). Nevertheless, little effort has been assigned to the study of fluorophore photostability under this condition. In this paper, the effect of photobleaching on the Raman signal enhancement factor (RS‐EF) of dye molecules on Ag‐modified silicon nanowire (SiNW) substrates is investigated. For this purpose, SiNWs are fabricated by using the vapor–liquid–solid growth mechanism and decorated with Ag NPs by means of electroless deposition method. This process provides the possibility of forming uniformly and tightly packed Ag NPs on SiNWs. The effect of photostability of the crystal violet as analyte molecules on surface‐enhanced Raman spectroscopy is investigated as a function of time evolution and laser power. The influence of Ag NP deposition time on Raman signal enhancement is explored. Our work shows how we can optimize the excitation power for achievement of higher RS‐EF and, consequently, lower detectable concentration. Time evolution of surface‐enhanced Raman spectroscopy signal shows an exponential decay behavior, which indicates an almost uniform distribution of EFs. Capability of our nanostructure is assessed for different concentration, and subsequently, limit of detection of 10 pm with RS‐EF of 2.4×109 is obtained. Copyright © 2017 John Wiley & Sons, Ltd.

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Direct and Label‐Free Detection of Solid‐Phase‐Bound Compounds by Using Surface‐Enhanced Raman Scattering Microspectroscopy

Cited by 44 publications

References 35 publications

Surface‐Enhanced Raman Spectroscopy: Concepts and Chemical Applications

Surface‐Enhanced Raman Spectroscopy: Concepts and Chemical Applications

Three‐Phase Interlines Electrochemically Driven into Insulator Compounds: A Penetration Model and Its Verification by Electroreduction of Solid AgCl

Surface‐enhanced Raman spectroscopy of dye molecules on Ag‐modified silicon nanowire substrates: influence of photoinduced probe degradation on enhancement factors

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