Direct and specific assessment of axonal injury and spinal cord microenvironments using diffusion correlation imaging

Benjamini, Dan; Hutchinson, Elizabeth; Komlosh, Michal E.; Comrie, Courtney; Schwerin, Susan C.; Pierpaoli, Carlo; Basser, Peter J.

doi:10.1016/j.neuroimage.2020.117195

Cited by 24 publications

(17 citation statements)

References 111 publications

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“…Nevertheless, the pathological meaning of the WM alteration revealed by the R2* value remains elusive. The WM alteration, as indicated by the decrease in R2*, might be due to demyelination followed by Wallerian degeneration ( Benjamini et al, 2020 , Tagliaferro and Burke, 2016 ). This degeneration is caused by injury or neural cell death due to neurotoxin exposure caused by α-synuclein, which contributes to PD pathology ( Burke and O'Malley, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

R2* relaxometry analysis for mapping of white matter alteration in Parkinson’s disease with mild cognitive impairment

Kan

Uchida

Ueki

et al. 2022

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 99%

R2* relaxometry analysis for mapping of white matter alteration in Parkinson’s disease with mild cognitive impairment

Kan

Uchida

Ueki

et al. 2022

NeuroImage: Clinical

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“…However, the diffusivity parallel to the axonal pathways remained stable after injury. This showed that the axonal pathways in the residual tissue were preserved [ 41 , 42 ] but underwent demyelination [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

et al. 2022

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Clinical evaluations of long-term outcomes in the early-stage spinal cord injury (SCI) focus on macroscopic motor performance and are limited in their prognostic precision. This study was designed to investigate the sensitivity of the magnetic resonance imaging (MRI) indexes to the data-driven gait process after SCI. Ten adult female rhesus monkeys were subjected to thoracic SCI. Kinematics-based gait examinations were performed at 1 (early stage) and 12 (chronic stage) months post-SCI. The proportion of stepping (PS) and gait stability (GS) were calculated as the outcome measures. MRI metrics, which were derived from structural imaging (spinal cord cross-sectional area, SCA) and diffusion tensor imaging (fractional anisotropy, FA; axial diffusivity, λ // ), were acquired in the early stage and compared with functional outcomes by using correlation analysis and stepwise multivariable linear regression. Residual tissue SCA at the injury epicenter and residual tissue FA/remote normal-like tissue FA were correlated with the early-stage PS and GS. The extent of lesion site λ // /residual tissue λ // in the early stage after SCI was correlated with the chronic-stage GS. The ratios of lesion site λ // to residual tissue λ // and early-stage GS were predictive of the improvement in the PS at follow-up. Similarly, the ratios of lesion site λ // to residual tissue λ // and early-stage PS best predicted chronic GS recovery. Our findings demonstrate the predictive power of MRI combined with the early data-driven gait indexes for long-term outcomes. Such an approach may help clinicians to predict functional recovery accurately.

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“…In biological applications, relaxation-diffusion multidimensional MR provides information from compositionally-and microstructurally-diverse environments, thus offering a probe of tissue heterogeneity. More recently, the use of multidimensional MRI to capture sub-voxel information has been gaining attention, leading to increased specificity and sensitivity towards a range of biological states and diseases [5][6][7][8][9].…”

mentioning

confidence: 99%

Editorial: Capturing Biological Complexity and Heterogeneity Using Multidimensional MRI

2022

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Direct and specific assessment of axonal injury and spinal cord microenvironments using diffusion correlation imaging

Cited by 24 publications

References 111 publications

R2* relaxometry analysis for mapping of white matter alteration in Parkinson’s disease with mild cognitive impairment

R2* relaxometry analysis for mapping of white matter alteration in Parkinson’s disease with mild cognitive impairment

MRI metrics at the epicenter of spinal cord injury are correlated with the stepping process in rhesus monkeys

Editorial: Capturing Biological Complexity and Heterogeneity Using Multidimensional MRI

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