Direct Aqueous Self-Assembly of an Amphiphilic Diblock Copolymer toward Multistimuli-Responsive Fluorescent Anisotropic Micelles

Abstract

It is extremely important for emerging applications and still enormously challenging to develop multifunctional stimuli-responsive anisotropic polymeric micelles with integration of potentially targeted therapeutic and diagnostic function. Herein, we report a first example of fluorescent anisotropic micelles (FAMs) with Fe(3+), DTT, H2O2, and thermal responsive fluorescence and morphology. FAMs from direct aqueous self-assembly of amphiphilic diblock copolymer showed reversible "switch off/on" of aqua fluorescent emission and controllable structural change by sequential addition of Fe(3+) and DTT. In addition, the FAMs had reversible dual-thermal responsiveness of fluorescence and morphology. This micelle could serve as a promising candidate for all-in-one application of quantitative detecting, imaging, drug delivery, and targeted release.

Selective Metal-Ion-Mediated Vesicle Adhesion Based on Dynamic Self-Organization of a Pyrene-Appended Glutamic Acid

“…5 µM for Fe 3+ . 44 Another remarkable fluorescence change is aroused by the addition of Al 3+ . Different from other metal ion influences, Al 3+ enhanced the excimer emission of PGlu, which enabled the easy visual detection.…”

A Step‐by‐Step Multiple Stimuli‐Responsive Nanoplatform for Enhancing Combined Chemo‐Photodynamic Therapy

“…[16] These strategies are frequently employed to enhance cellular uptake, including grafting target moieties on nanoparticles, [12,17] changing the morphology of the nanoparticles, [18,19] and reducing the size of the nanoparticles. [37][38][39] pH and redox stimuli are always employed in combination based on the coexistence of a pH gradient and an oxidative environment in cancer cells. [22][23][24] To accelerate endosomal escape and realize controllable intracellular drug release, on-demand drug delivery is becoming feasible through the design of stimuli-responsive systems that recognize the microenvironment and react in a dynamic way.…”

Salicylaldehyde-functionalized block copolymer nano-objects: one-pot synthesis via polymerization-induced self-assembly and their simultaneous cross-linking and fluorescence modification

“…[1][2][3][4][5][6] These block copolymer nano-objects have received much attention in the past decades owing their numerous potential applications, for instance in nanomedicine, cosmetics, catalysis and sensing. [1][2][3][4][5][6][7][8][9][10][11][12][13] Recently, the so-called polymerization induced self-assembly (PISA) has been demonstrated to be a robust and efficient route for the direct in situ synthesis of block copolymer nano-objects of various morphologies at relatively high copolymer concentrations (up to 50 % solids). However, preparation of block copolymer nano-objects requires time consuming multiple-steps, including generally synthesis, characterization, and purification of amphiphilic copolymers followed by their self-assembly in selective solvents and solvent displacement.…”