Direct Association between C-reactive Protein Serum Levels and Endothelial Dysfunction in Patients with Claudication

Haro, Joaquín De; Aciń, Francisco; López-Quintana, A.; Medina, Francisco J.; Martínez-Aguilar, E.; Flórez, Aurora Martínez; March, José Ramón

doi:10.1016/j.ejvs.2007.10.016

Cited by 25 publications

(27 citation statements)

References 37 publications

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“…shown that systemic inflammation was associated with impairment of endothelial function in patients with PAD [29][30][31], but we found no significant differences in serum high sensitivity C-reactive protein concentrations between patients with single vascular disease and those with PolyVD. However, there were significant differences in age, smoking histories, hypertension, CKD, and HbA1c between patients with a single vascular disease and those with PolyVD, which concurs with the findings of a previous study [8].…”

Section: Variablecontrasting

confidence: 73%

Advanced peripheral microvascular endothelial dysfunction and polyvascular disease in patients with high cardiovascular risk

Makino

Sugiyama

Jinnouchi³

et al. 2016

Journal of Cardiology

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Section: Variablecontrasting

confidence: 73%

Advanced peripheral microvascular endothelial dysfunction and polyvascular disease in patients with high cardiovascular risk

Makino

Sugiyama

Jinnouchi³

et al. 2016

Journal of Cardiology

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“…There is scientiWc evidence pointing to atherosclerosis as an inXammatory disease (De Haro et al 2008;Hamer and Stamatakis 2008;Virani et al 2008) and some of the most prevalent risk factors for cardiovascular diseases have been shown to have a pro-inXammatory action including high lipid levels (Kim et al 2007), hypertension (Imatoh et al 2007;Hamer and Stamatakis 2008), diabetes (Porrini et al 2007;Hwang et al 2008) and obesity (Hamer and Stamatakis 2008;Piestrzeniewicz et al 2008). C-reactive protein (CRP), a sensitive marker of inXammation, has also been related to increased risk of vascular disease (Koenig et al 1999;Kuller et al 1996;Ridker et al 1998a;Ridker et al 2002;Ridker et al 2003).…”

Section: Introductionmentioning

confidence: 99%

The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults

et al. 2010

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Increased levels of inflammatory markers, namely, high-sensitive C-reactive protein (hs-CRP), have been associated with several chronic diseases including atherosclerosis, type 2 diabetes and hypertension. Forty-five women and men aged >64 years participated in the study and were randomly assigned to two exercise intervention groups and a non-exercising control group. The participants assigned to the exercising groups followed a 16-week exercise protocol based either on aerobic training (AT) or strength training (ST) followed by a further 16 weeks off-training period. The control group (C) remained sedentary throughout the study. Evaluation of body mass, BMI, waist circumference, aerobic endurance, lower-body strength, upper-body strength, triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol and hs-CRP were performed at baseline, after 16 weeks (post-training for the exercise groups) and at 32 weeks (follow-up). Both, AT and ST groups significantly increased functional fitness at the end of the exercise programs when compared to baseline values. hs-CRP concentrations were maintained throughout the study for the C group, while decreasing 10% at 16 weeks and 51% at 32 weeks for the AT group. In the ST group the hs-CRP concentrations decreased by 11 and 39% at 16 and 32 weeks, respectively. Decreases in hs-CRP concentrations were statistically significant for the AT and ST groups at the 32-week evaluation when compared to baseline. Reduction in hs-CRP concentrations seemed to be associated with strength gains and adiposity loss.

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“…De fato, o braço aferente do reflexo pressor tem sua origem nas fibras III e IV do músculo esquelético e essas fibras são estimuladas pela contração, principalmente, em condições isquêmicas 13 . Outra hipótese é que a disfunção endotelial e os agentes pró-inflamatórios, que são mais acentuados nesses pacientes 20,21 , tenham atenuado a vasodilatação da musculatura ativa, aumentando, por consequência a PAD.…”

Section: Discussionunclassified

Respostas cardiovasculares ao teste ergométrico em indivíduos com claudicação intermitente. DOI: 10.5007/1980-0037.2011v13n3p208

Cucato

Rodrigues

Farah

et al. 2011

Rev. Bras. Cineantropom. Desempenho Hum.

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Resumo -Estudos sugerem que pacientes com claudicação intermitente (CI) apresentam respostas hemodinâmicas alteradas durante o teste ergométrico. Contudo, o impacto da severidade da doença nessas respostas ainda não está claro. Em vista disso, o presente estudo analisou o impacto da severidade dos sintomas de CI nas respostas cardiovasculares ao teste de esforço, em indivíduos com doença arterial obstrutiva periférica. Participaram do estudo 47 sujeitos com CI. Foi realizado teste ergométrico em esteira, utilizando protocolo específico para essa população. A amostra foi dividida em três grupos de acordo com a distância obtida no teste de esforço em: 1º tercil, caminhavam entre 210 e 420 metros; 2º tercil, caminhavam entre 450 e 700 metros; e 3º tercil, caminhavam entre 740 e 1060 metros. A pressão arterial sistólica (PAS) e diastólica (PAD), a frequência cardíaca (FC) e o duplo produto (DP) foram obtidos em repouso, no primeiro estágio e no pico de esforço. Nos três tercis, a PAS e a PAD aumentaram significantemente ao longo do teste ergomé-trico. Nos três tercis, a FC e o DP aumentaram significantemente ao longo do teste e as respostas no 1º tercil foram mais acentuadas que nos demais tercis. Todavia, no pico de esforço, a FC e o DP não houve diferença entre os tercis. Concluíu-se que a severidade da CI não influenciou as respostas da pressão arterial durante o teste ergométrico progressivo, ao passo que maiores valores de FC e DP foram observados em indivíduos com CI mais severa em uma carga submáxima. Palavras-chave: Claudicação intermitente; Caminhada; Teste de esforço. Abstract -Studies suggest that patients with intermittent claudication (IC) present abnormal cardiovascular responses during treadmill exercise. However, it remains unclear whether this response is influenced by the severity of the disease. The objective of this study was to analyze the impact of IC severity on cardiovascular responses to an exercise test in subjects with

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Direct Association between C-reactive Protein Serum Levels and Endothelial Dysfunction in Patients with Claudication

Abstract: Impaired endothelial dysfunction is association with increased plasma concentrations of inflammatory markers, and both may have a role in the aetiopathogenesis of peripheral arterial disease.

Cited by 25 publications

References 37 publications

Advanced peripheral microvascular endothelial dysfunction and polyvascular disease in patients with high cardiovascular risk

Advanced peripheral microvascular endothelial dysfunction and polyvascular disease in patients with high cardiovascular risk

The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults

Respostas cardiovasculares ao teste ergométrico em indivíduos com claudicação intermitente. DOI: 10.5007/1980-0037.2011v13n3p208

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