2024
DOI: 10.1021/jacs.3c14058
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Direct C–H Hydroxylation of N-Heteroarenes and Benzenes via Base-Catalyzed Halogen Transfer

Kendelyn I. Bone,
Thomas R. Puleo,
Jeffrey S. Bandar

Abstract: Hydroxylated (hetero)arenes are valued in many industries as both key constituents of end products and diversifiable synthetic building blocks. Accordingly, the development of reactions that complement and address the limitations of existing methods for the introduction of aromatic hydroxyl groups is an important goal. To this end, we apply base-catalyzed halogen transfer (X-transfer) to enable the direct C−H hydroxylation of mildly acidic N-heteroarenes and benzenes. This protocol employs an alkoxide base to … Show more

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Cited by 8 publications
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References 153 publications
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