Direct capture and smartphone quantification of airborne SARS-CoV-2 on a paper microfluidic chip

Kim, Sangsik; Akarapipad, Patarajarin; Nguyen, Brandon; Breshears, Lane E.; Baker, Jacob; Uhrlaub, Jennifer L.; Nikolich‐Žugich, Janko; Yoon, Jeong‐Yeol

doi:10.1016/j.bios.2021.113912

Cited by 28 publications

(14 citation statements)

References 18 publications

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“…Recently, POC testing techniques including lateral flow technologies [ 127 , 128 ], paper-based microfluidic chips [ 129 , 130 ], isothermal nucleic acid amplification devices [ 131 , 132 ], etc, have been developed for visual detection of COVID-19. The popularization of mobile communications has greatly increased the efficiency of acquisition, processing and transmission of test data.…”

Section: Sars-cov-2 Infection Mechanism and Diagnostic Methodsmentioning

confidence: 99%

Visual Detection of COVID-19 from Materials Aspect

Wang

Meng

et al. 2022

Adv. Fiber Mater.

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In the recent COVID-19 pandemic, World Health Organization emphasized that early detection is an effective strategy to reduce the spread of SARS-CoV-2 viruses. Several diagnostic methods, such as reverse transcription-polymerase chain reaction (RT-PCR) and lateral flow immunoassay (LFIA), have been applied based on the mechanism of specific recognition and binding of the probes to viruses or viral antigens. Although the remarkable progress, these methods still suffer from inadequate cellular materials or errors in the detection and sampling procedure of nasopharyngeal/oropharyngeal swab collection. Therefore, developing accurate, ultrafast, and visualized detection calls for more advanced materials and technology urgently to fight against the epidemic. In this review, we first summarize the current methodologies for SARS-CoV-2 diagnosis. Then, recent representative examples are introduced based on various output signals (e.g., colorimetric, fluorometric, electronic, acoustic). Finally, we discuss the limitations of the methods and provide our perspectives on priorities for future test development. Graphical Abstract

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Section: Sars-cov-2 Infection Mechanism and Diagnostic Methodsmentioning

confidence: 99%

Visual Detection of COVID-19 from Materials Aspect

Wang

Meng

et al. 2022

Adv. Fiber Mater.

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“…9 Recently, Kim et al, presented the design and working of a smartphone microscopy system in conjunction with a paper-based platform for imaging and quantification of SARS-CoV-2 virus. 10 Similarly, in ref. 11, the working and design of another fluorescent microscopy system capable of doing ELISA is discussed.…”

Section: Introductionmentioning

confidence: 91%

Excitation modalities for enhanced micro and nanoparticle imaging in a smartphone coupled 3D printed fluorescent microscope

2022

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“…Optical gas sensors rely on the change in the absorbance/color [ 18 , 19 , 24 , 34 ], luminescence [ 25 , 26 , 27 , 28 ], or change in the Raman signature [ 15 , 31 , 32 , 33 ] of the sensing material to detect the presence of the target analyte. Results obtained from some of the optical sensors can be seen by the naked eye, which allows for the easy miniaturization of the sensor since it does not require any external device or power supply.…”

Section: Detection Approachesmentioning

confidence: 99%

“…Typical dyes used in such scenarios are cell permeable and show very high fluorescence when bound to DNA or RNA. (2) The use of antibody-conjugated fluorescent particles for detecting viruses [ 26 ]. (3) loop-mediated isothermal amplification technique (LAMP) to detect bacteria and viruses [ 28 ].…”

Section: Detection Approachesmentioning

confidence: 99%

Microfluidic Gas Sensors: Detection Principle and Applications

et al. 2022

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With the rapid growth of emerging point-of-use (POU)/point-of-care (POC) detection technologies, miniaturized sensors for the real-time detection of gases and airborne pathogens have become essential to fight pollution, emerging contaminants, and pandemics. However, the low-cost development of miniaturized gas sensors without compromising selectivity, sensitivity, and response time remains challenging. Microfluidics is a promising technology that has been exploited for decades to overcome such limitations, making it an excellent candidate for POU/POC. However, microfluidic-based gas sensors remain a nascent field. In this review, the evolution of microfluidic gas sensors from basic electronic techniques to more advanced optical techniques such as surface-enhanced Raman spectroscopy to detect analytes is documented in detail. This paper focuses on the various detection methodologies used in microfluidic-based devices for detecting gases and airborne pathogens. Non-continuous microfluidic devices such as bubble/droplet-based microfluidics technology that have been employed to detect gases and airborne pathogens are also discussed. The selectivity, sensitivity, advantages/disadvantages vis-a-vis response time, and fabrication costs for all the microfluidic sensors are tabulated. The microfluidic sensors are grouped based on the target moiety, such as air pollutants such as carbon monoxide and nitrogen oxides, and airborne pathogens such as E. coli and SARS-CoV-2. The possible application scenarios for the various microfluidic devices are critically examined.

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Direct capture and smartphone quantification of airborne SARS-CoV-2 on a paper microfluidic chip

Cited by 28 publications

References 18 publications

Visual Detection of COVID-19 from Materials Aspect

Visual Detection of COVID-19 from Materials Aspect

Excitation modalities for enhanced micro and nanoparticle imaging in a smartphone coupled 3D printed fluorescent microscope

Microfluidic Gas Sensors: Detection Principle and Applications

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