Direct comparison of solid-phase extraction and solid-phase microextraction for the gas chromatographic determination of dibenzylamine in artificial saliva leachates from baby bottle teats

Niessner, Georg; Klampfl, Christian W.

doi:10.1016/s0003-2670(00)00833-3

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…After preconcentration to 1 ml, the ethyl acetate extracts were directly injected into the GC‐TOF MS for both target and nontarget analysis, with the objective of investigating the presence in the samples of more polar compounds. N ‐(phenylmethyl)‐benzenemethanamine, also called dibenzylamine, a thermal decomposition product of the vulcanization agent zinc dibenzyldithiocarbamate and a possible precursor to the formation of N ‐nitrosodibenzylamine,40 was discovered in four out of ten ethyl acetate extracts. Dibenzylamine has also been found by other authors in artificial saliva leachates from baby bottle teats40 and in human‐plasma and urine samples 41.…”

Section: Resultsmentioning

confidence: 99%

Searching for anthropogenic contaminants in human breast adipose tissues using gas chromatography‐time‐of‐flight mass spectrometry

et al. 2008

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The potential of GC-TOF MS for screening anthropogenic organic contaminants in human breast adipose tissues has been investigated. Initially a target screening was performed for a list of 125 compounds which included persistent halogen pollutants (OC pesticides, PCBs, PBDEs), PAHs, alkylphenols, and a notable number of pesticides from the different fungicide, herbicide and insecticide families. Searching for target pollutants was done by evaluating the presence of up to five representative ions for every analyte, all measured at accurate mass (20 mDa mass window). The experimental ion abundance ratios were then compared to those of reference standards for confirmation. Sample treatment consisted of an extraction with hexane and subsequent normal-phase HPLC or SPE clean-up. The fat-free LC fractions were then investigated by GC-TOF MS.Full-spectral acquisition and accurate mass data generated by GC-TOF MS also allowed the investigation of non-target compounds using appropriate processing software to manage MS data. Identification was initially based on library fit using commercial nominal mass libraries.This was followed by comparing the experimental accurate masses of the most relevant ions with the theoretical exact masses with calculations made using the elemental composition calculator included in the software.The application of both target and non-target approaches to around 40 real samples allowed the detection and confirmation of several target pollutants including p,p'-DDE, HCB, and some PCBs and PAHs. Several non-target compounds that could be considered anthropogenic pollutants were also detected. These included 3,5-di-tert-butyl-4-hydroxy-toluene (BHT) and its metabolite 3,5-di-tert-butyl-4-hydroxybenzaldehyde (BHT-CHO), dibenzylamine, n-butyl benzenesulfonamide, some naphthalene-related compounds and several PCBs isomers not 3 included in the target list. As some of the compounds detected are xenoestrogens the methodology developed in this paper could be useful in human breast cancer research.4

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Section: Resultsmentioning

confidence: 99%

Searching for anthropogenic contaminants in human breast adipose tissues using gas chromatography‐time‐of‐flight mass spectrometry

et al. 2008

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“…Each sample (about 1 g) was immersed in 5 mL of artificial saliva in a glass container. The artificial saliva was prepared according to a previous literature (Kusu et al, 1998;Niessner and Klampfl, 2000) and the details are provided in supporting information. The containers were filled without headspace and sealed hermetically.…”

Section: Artificial Saliva Leaching Experimentsmentioning

confidence: 99%

Methylsiloxanes in children silicone-containing products from China: Profiles, leaching, and children exposure

Zhi

Cai

2017

Environment International

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“…Therefore, it is necessary to monitor the safety of various baby bottle teats and kitchen tool products that are currently on the market. However, earlier studies on N-nitrosamines present in baby bottles have mainly focused on the development of analytical methods [16][17][18], and studies reporting the monitoring of baby bottle teats or rubber kitchen tool products are still lacking. In particular, the monitoring of N-nitrosamine migration from baby bottle teats and rubber kitchen tools has not been performed using LC-MS/MS.…”

Section: Introductionmentioning

confidence: 99%

Release of N-nitrosamines and N-nitrosatable substances from baby bottle teats and rubber kitchen tools in Korea

Park

Jeong

Park

et al. 2018

Food Sci Biotechnol

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Ensuring the safety of baby bottle teats and kitchen tools made from rubber is critical. Therefore, the migration of N-nitrosamines and N-nitrosatable substances from 30 teats and 45 kitchen tools to artificial saliva was analyzed by liquid chromatography-tandem mass spectrometry. The method was validated by assessing the limits of detection (0.46-3.87 lg/kg), limits of quantification (1.38-11.73 lg/kg), and recoveries (86.3-108.6%) of seven compounds. Nitrosodimethylamine (NDMA), N-nitrosopiperidine, and N-nitrosomorpholine (NMOR) migrated from baby bottle teats at concentrations of not detected (ND) to 3.67 lg/kg. NDMA and NMOR concentrations ranged from ND to 1.72 lg/kg after migration from 45 rubber kitchen tools. N-nitrosatable substances ranged from ND to 42.16 lg/kg after migration from baby bottle teats but did not migrate from rubber kitchen tools. All tested products were considered safe for use, as N-nitrosamine and N-nitrosatable substance levels did not exceed the permitted management specifications.Keywords N-nitrosamines Á N-nitrosatable substances Á Baby bottle teat Á Rubber kitchen tool Á LC-MS/MS

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Direct comparison of solid-phase extraction and solid-phase microextraction for the gas chromatographic determination of dibenzylamine in artificial saliva leachates from baby bottle teats

Cited by 6 publications

References 13 publications

Searching for anthropogenic contaminants in human breast adipose tissues using gas chromatography‐time‐of‐flight mass spectrometry

Searching for anthropogenic contaminants in human breast adipose tissues using gas chromatography‐time‐of‐flight mass spectrometry

Methylsiloxanes in children silicone-containing products from China: Profiles, leaching, and children exposure

Release of N-nitrosamines and N-nitrosatable substances from baby bottle teats and rubber kitchen tools in Korea

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