2007
DOI: 10.1016/j.ejheart.2007.01.003
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Direct comparison of transcardiac difference between brain natriuretic peptide (BNP) and N‐terminal pro‐BNP in patients with chronic heart failure

Abstract: Background: Direct comparison of transcardiac increase in brain natriuretic peptide (BNP) and NT-pro-BNP has not been performed previously. Aims: To evaluate the relation between BNP and NT-pro-BNP secretion, plasma levels and renal function. Methods: We measured the plasma levels of BNP and NT-pro-BNP in the aortic root and coronary sinus in 326 consecutive patients with chronic heart failure (CHF). Patients were divided into two groups [group I: estimated glomerular filtration rate (eGFR) ≥ 60 mL/min and gro… Show more

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Cited by 30 publications
(21 citation statements)
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“…Several other studies support the idea that the influence of renal function on plasma NTproBNP is greater than that on BNP since its clearance is predominantly renal while BNP's clearance is rather peripheral [59][60][61]. According to Kroll and Srisawasdi [33] the plasma ratio between BNP and NTproBNP is nonlinear throughout the different classes of HF.…”
Section: Renal Failure/eliminationmentioning
confidence: 90%
“…Several other studies support the idea that the influence of renal function on plasma NTproBNP is greater than that on BNP since its clearance is predominantly renal while BNP's clearance is rather peripheral [59][60][61]. According to Kroll and Srisawasdi [33] the plasma ratio between BNP and NTproBNP is nonlinear throughout the different classes of HF.…”
Section: Renal Failure/eliminationmentioning
confidence: 90%
“…In previous studies, including ours, parameters such as LVEDP, LVEF, left ventricular (LV) mass index, anemia (hemoglobin) and renal function (eGFR) were confirmed as prognostic markers, respectively, influencing the plasma levels of BNP and NTproBNP. 10,16,22,23 Hence, a single measurement of BNP and NT-proBNP in plasma may be a stronger prognostic indicator than hemodynamics and the transcardiac increases in BNP and NT-proBNP in patients with CHF.…”
Section: Discussionmentioning
confidence: 99%
“…1 Plasma levels of NTproBNP were measured using the Elecsys proBNP sandwich immunoassay (Roche Diagnostics), as reported elsewhere. 10 …”
Section: Measurement Of Bnp and Nt-probnpmentioning
confidence: 99%
“…6,7 In HF with reduced LVEF, previous studies have demonstrated a modest relationship between the transcardiac BNP gradient, that is, the difference between BNP concentrations in arterial and coronary sinus blood (⌬ A-CS BNP) as an invasive measure of myocardial BNP release, and pulmonary capillary wedge pressure (PCWP), LV end-diastolic pressure, and LV dimensions. 4,8,9 However, to date no studies of transcardiac BNP dynamics have included subjects with normal LVEF and impaired LV diastolic function, and as such the biological plausibility of extending BNP as a biomarker to this group of patients is lacking.…”
mentioning
confidence: 99%