Direct comparison of two vaginal self-sampling devices for the detection of human papillomavirus infections

Jentschke, Matthias; Chen, K.; Arbyn, Marc; Hertel, B.; Noskowicz, Monika; Soergel, Philipp; Hillemanns, Peter

doi:10.1016/j.jcv.2016.06.016

Cited by 46 publications

(53 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results are also in agreement with a recent study that compared 2 vaginal self-sampling devices for the detection of hrHPV, in which the concordance between Qvintip ® and clinician-collected samples was 89% (kappa = 0.78) [24].…”

Section: Discussionsupporting

confidence: 92%

High-Risk Types of Human Papilloma Virus DNA Testing in Women with False Negative Cytology

et al. 2018

View full text Add to dashboard Cite

Objective: To determine whether high-risk types of human papilloma virus (hrHPV) DNA testing is reliable for selection patients in need of further investigation with colposcopy in women with increased risk of high-grade cervical lesions as a result of false negative cytology. The secondary objective was to compare the sensitivity of hrHPV testing on self-collected versus physician-collected samples for the detection of histological high-grade cervical intraepithelial neoplasia (CIN2+). Methods: Sixty-three patients identified with a missed abnormality following the re-evaluation of benign cervical cytology were included. A patient-collected and a physician-collected sample for HPV, colposcopy and cervical specimen collection for histology and cytology were performed. Results: The sensitivity of hrHPV testing of physician-collected samples for CIN2+ was 100% (95% CI 82.7–100), and the negative predictive value (NPV) was 100% (95% CI 93.3–100). The sensitivity of the self-sampling device to identify CIN2+ was 84.6% (95% CI 59.1–96.7), and the NPV was 94.4% (95% CI 83.4–98.8). The differences in the sensitivity and NPV between the 2 methods were non-significant. The agreement between the 2 methods regarding the HPV results was good, with a kappa value of 0.74 (95% CI 0.57–0.91). Conclusion: The current findings indicate that physician-collected samples for hrHPV DNA testing may be used as triage for the colposcopy of women with false negative cytology.

show abstract

Section: Discussionsupporting

confidence: 92%

High-Risk Types of Human Papilloma Virus DNA Testing in Women with False Negative Cytology

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Professional sampling is regarded as the gold standard, but it is known from cytology‐based screening programs that a small fraction of samples are not of diagnostic quality and/or not representative of endocervical sampling . The concordance observed in the present study of 83% was slightly lower than two previously reported values of 86% and 91% . As compared with the present age group (55–60 years), the age of the women in those studies was either not reported or younger (mean age 36 years) …”

Section: Discussioncontrasting

confidence: 91%

“…The concordance observed in the present study of 83% was slightly lower than two previously reported values of 86% and 91% . As compared with the present age group (55–60 years), the age of the women in those studies was either not reported or younger (mean age 36 years) …”

Section: Discussioncontrasting

confidence: 91%

Comparison between professional sampling and self‐sampling for HPV‐based cervical cancer screening among postmenopausal women

Bergengren

Kaliff

Lillsunde-Larsson

et al. 2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…Unfortunately, we found low DNA percentages exponentially increasing over age to >20% in the age‐group 60–64 years. A German study comparing the performance of the Qvintip with an another self‐sampling device, the Evalyn Brush (Rovers, Medical Devices) found similar hrHPV detection rates, however the observed mean DNA concentration was found to be higher with the Evalyn samples than of the Qvintip samples (mean concentration: 23.8; 95% CI: 23.2–24.4) . No stratification according to age group was performed.…”

Section: Discussionmentioning

confidence: 99%

“…A German study comparing the performance of the Qvintip with an another self-sampling device, the Evalyn Brush (Rovers, Medical Devices) found similar hrHPV detection rates, however the observed mean DNA concentration was found to be higher with the Evalyn samples than of the Qvintip samples (mean concentration: 23.8; 95% CI: 23.2-24.4). 25 No stratification according to age group was performed. To our knowledge, our study was the first to demonstrate an decrease in detected DNA concentration according to age.…”

Section: Discussionmentioning

confidence: 99%

A randomized, controlled trial of two strategies of offering the home‐based HPV self‐sampling test to non‐ participants in the Flemish cervical cancer screening program

Kellen

Benoy

Broeck

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

We conducted a randomized, controlled trial to evaluate different strategies of offering an HPV-self sampling program, and compared this with two control groups. All total of 35,354 women who did not participate in the Flemish cancer screening program were included in the study: 9,118 received a HPV self-collection brush (RIATOL qPCR HPV genotyping test (qPCR [E6/E7]); 9,098 were offered the opportunity to order an HPV-selfsampling brush, 8,830 received the recall letter; 8,849 received no intervention. Within 12 months after the mailing, 18.7% of the women who had received the brush, participated by returning a self-sample sample, while 10.6% women allocated to the opt- in group did so. 10.5% women who received the standard recall letter, had a PAP smear taken within a period of 12 months; while 8% women did so without receiving an intervention at all. Participation in postmenopausal women was higher than in women younger than 50 in both self-sampling arms. Screening by means of the self-sample kit increased by age, contradictory when screening is performed by a PAP smear. Of those testing hrHPV positive (9.5%), 88.9% attended for follow up cytology. The mean DNA concentration, found in the self-sampler, decreased by age, causing a higher number of inconclusive results. Our results support the efficacy of a self-sampling strategy to increase participation in the Flemish screening program. Self-sampling seems particularly acceptable to postmenopausal non-responders. Future research should focus on the performance of different self-sampling devices in post-menopausal women as low DNA concentrations exponentially increased over age.

show abstract

Direct comparison of two vaginal self-sampling devices for the detection of human papillomavirus infections

Cited by 46 publications

References 28 publications

High-Risk Types of Human Papilloma Virus DNA Testing in Women with False Negative Cytology

High-Risk Types of Human Papilloma Virus DNA Testing in Women with False Negative Cytology

Comparison between professional sampling and self‐sampling for HPV‐based cervical cancer screening among postmenopausal women

A randomized, controlled trial of two strategies of offering the home‐based HPV self‐sampling test to non‐ participants in the Flemish cervical cancer screening program

Contact Info

Product

Resources

About