Direct conjugation of distinct carbon dots as Lego-like building blocks for the assembly of versatile drug nanocarriers

Zhou, Yiqun; Mintz, Keenan J.; Cheng, Ling; Chen, Jiuyan; Ferreira, Braulio C.L.B.; Hettiarachchi, Sajini D.; Liyanage, Piumi Y.; Seven, Elif S.; Miloserdov, Nikolay; Pandey, Raja R.; Quiroga, Bruno A.; Blackwelder, Patricia; Chusuei, Charles C.; Li, Shanghao; Peng, Zhili; Leblanc, Roger M.

doi:10.1016/j.jcis.2020.05.005

Cited by 42 publications

(24 citation statements)

References 50 publications

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“…Moreover, Zhou et al in their study also mentioned a type of gel-like CDs which could cross the BBB using a zebrafish model. 56 Zebrafish has a high degree of similarity to human CNS physiology, including all major components of neural system such as transmitters, hormones, and receptors. 57 In addition, in comparison to mice, zebrafish reproduces a large number of offspring, which allows reproduction of experiments.…”

Section: Penetration Of Biological Barriers With Carbon Dotsmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

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Drug delivery across the blood–brain barrier (BBB) is one of the biggest challenges in modern medicine due to the BBB’s highly semipermeable property that limits most therapeutic agents of brain diseases to enter the central nervous system (CNS). In recent years, nanoparticles, especially carbon dots (CDs), exhibit many unprecedented applications for drug delivery. Several types of CDs and CD-ligand conjugates have been reported successfully penetrating the BBB, which shows a promising progress in the application of CD-based drug delivery system (DDS) for the treatment of CNS diseases. In this review, our discussion of CDs includes their classification, preparations, structures, properties, and applications for the treatment of neurodegenerative diseases, especially Alzheimer’s disease (AD) and brain tumor. Moreover, abundant functional groups on the surface, especially amine and carboxyl groups, allow CDs to conjugate with diverse drugs as versatile drug nanocarriers. In addition, structure of the BBB is briefly described, and mechanisms for transporting various molecules across the BBB and other biological barriers are elucidated. Most importantly, recent developments in drug delivery with CDs as BBB-penetrating nanodrugs and drug nanocarriers to target CNS diseases especially Alzheimer’s disease and brain tumor are summarized. Eventually, future prospects of the CD-based DDS are discussed in combination with the development of artificial intelligence and nanorobots.

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Section: Penetration Of Biological Barriers With Carbon Dotsmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

Self Cite

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“…In the last ten years, many applications of CDs in cancer theranostics were reported. Specifically, numerous researchers evaluated the possible use of CDs as targeted anticancer drug delivery [ 84 ], photodynamic therapy [ 85 ], photothermal therapy [ 86 ], as well as gene delivery [ 87 ] for cancer theranostic. This section will discuss some in vitro and in vivo applications of CDs for cancer therapy.…”

Section: Cds For Cancer Therapymentioning

confidence: 99%

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

Nocito

Calabrese

Forte³

et al. 2021

Cancers

104

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Carbon Dots (CDs) are the latest members of carbon-based nanomaterials, which since their discovery have attracted notable attention due to their chemical and mechanical properties, brilliant fluorescence, high photostability, and good biocompatibility. Together with the ease and affordable preparation costs, these intrinsic features make CDs the most promising nanomaterials for multiple applications in the biological field, such as bioimaging, biotherapy, and gene/drug delivery. This review will illustrate the most recent applications of CDs in the biomedical field, focusing on their biocompatibility, fluorescence, low cytotoxicity, cellular uptake, and theranostic properties to highlight above all their usefulness as a promising tool for cancer diagnosis and therapy.

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“…For example, synthesized black CDs and carbon nitride dots appear to be more functionalized to a greater degree and more disordered and amorphous than yellow-CDs [124]. A direct conjugation of black CDs and gel-like CDs takes place through an amidation reaction to display many unique properties on novel drug carriers [125]. Amphiphilic CDs have been synthesized through hydrothermal carbonization using saccharides (D-glucose, D-galactose, and D-lactose) as the precursors [126].…”

Section: Carbon Dotsmentioning

confidence: 99%

Carbon Nanotubes, Graphene, and Carbon Dots as Electrochemical Biosensing Composites

Pandey

Chusuei

2021

Molecules

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Carbon nanomaterials (CNMs) have been extensively used as electrochemical sensing composites due to their interesting chemical, electronic, and mechanical properties giving rise to increased performance. Due to these materials’ unknown long-term ecological fate, care must be given to make their use tractable. In this review, the design and use of carbon nanotubes (CNTs), graphene, and carbon dots (CDs) as electrochemical sensing electrocatalysts applied to the working electrode surface are surveyed for various biosensing applications. Graphene and CDs are readily biodegradable as compared to CNTs. Design elements for CNTs that carry over to graphene and CDs include Coulombic attraction of components and using O or N atoms that serve as tethering points for attaching electrocatalytically active nanoparticles (NPs) and/or other additives.

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Direct conjugation of distinct carbon dots as Lego-like building blocks for the assembly of versatile drug nanocarriers

Cited by 42 publications

References 50 publications

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Carbon Dots as Promising Tools for Cancer Diagnosis and Therapy

Carbon Nanotubes, Graphene, and Carbon Dots as Electrochemical Biosensing Composites

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