Direct Control of Drug Release Behavior from Layered Double Hydroxides through Particle Interactions

Gunawan, Poernomo; Xu, Rong

doi:10.1002/jps.21321

Cited by 80 publications

(59 citation statements)

References 44 publications

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“…This is the first report on round platelet-like large-sized IBU-LDH nanoparticles obtained in aqueous solution system, and the observed morphology is quite different from the previous reports. 10,17,27 It can be seen that the average particle size of MA-IBU-H-i nanohybrids is increased gradually from 350 to 530 nm, greatly larger than that of MA-IBU-C ($150 nm), with increasing aging time (Table 1), consistent with the XRD data. As Feng et al 25,28 reported on hydrothermal and solvothermal synthetic chemistry and put forward that the reactivity in autoclave can be greatly improved under the high temperature and autocreated pressure when the solvent reached critical or supercritical state.…”

Section: Crystal Structure and Morphologysupporting

confidence: 91%

“…Evidently, the previous studies on drug-LDH hybrids are mainly focused on the synthesis, characterization, and in vitro release behavior, but less on the release mechanism with direct evidence through monitoring the whole release process of well-defined largesized drug-LDH nanohybrid particles, thus approaching to the range of particle size suitable for drug delivery. 16 Recently, Gunawan and Xu 17 claimed that the various aggregation states of the IBU-Mg-Al LDH particles, obtained by hydrothermal and coprecipitation step under varied solvent system and aging conditions, can impact the diffusion path length of IBU and thus the release rate, while no concern on the subtle influence of size and morphology of the single platelet particles. However, it is hard to illustrate the detailed release process and mechanism merely upon the morphology observations of the pristine sample and recovered one at the end of release test.…”

Section: Introductionmentioning

confidence: 99%

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Study on the release behavior and mechanism by monitoring the morphology changes of the large-sized drug-LDH nanohybrids

2010

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in Wiley Online Library (wileyonlinelibrary.com).Mg-Al layered double hydroxide (LDH) nanohybrids intercalated with ibuprofen (IBU) with particle sizes of 150-530 nm have been synthesized through hydrothermal and coprecipitation treatment in aqueous solution without any organic solvent. The in vitro drug release properties of as-prepared IBU-LDH nanohybrids are systematically studied and the kinetic simulation to the release profiles suggests that the release processes of the larger nanohybrids are mainly controlled by intraparticle diffusion. The morphology changes from thick sheet-like into thin margin-curved platelets for the larger nanohybrid particles, induced by the hydrophobic IBU anions aggregations located in the edge region of interlayer via ion-exchange diffusion process, is firstly observed during the release process. Based on the SEM, HRTEM, XRD, FTIR, and UV-vis analyses of the samples recovered at different release time, a release mechanism model of the as-prepared IBU-LDH nanohybrids is tentatively proposed along with their morphology changes during the whole release process.

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Section: Crystal Structure and Morphologysupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Study on the release behavior and mechanism by monitoring the morphology changes of the large-sized drug-LDH nanohybrids

2010

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“…[55] Gunawan et al manipulated the aggregation of LDH particles by controlling synthetic conditions. LDHs synthesised in the mixture of ethylene glycol and water and aged hydrothermally exhibited regularly shaped particles and upon drying they formed relatively oriented dense powder through preferential face-to-face aggregation [ In this report, the drug release from drug-LDH was investigated in vitro simulating the passage through the gastrointestinal tract, where the pH is $1.2 and $6-7 in the stomach and intestine, respectively.…”

Section: Layered Nanomaterialsmentioning

confidence: 99%

Biomedical Applications of Layered Double Hydroxides

Park

2010

Low‐Dimensional Solids

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“…Therefore, this suggests that IBU anions were arranged as monolayers in the interlayer of LZH. 33 Figure 3b shows IBU anions intercalated in the interlayer space.…”

Section: Pxrd and Structural Modelmentioning

confidence: 98%

Layered zinc hydroxide–ibuprofen nanohybrids: synthesis and characterization

Nabipour

Sadr

2015

Bull Mater Sci

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The nonsteroidal anti-inflammatory drug (NSAID), ibuprofen (IBU) anion, was intercalated into the layered zinc hydroxide (LZH) to form a new organic-inorganic nanohybrid. Then, IBU-LZH nanohybrid was dispersed into chitosan for the formation of the nanocomposite. The IBU-LZH nanohybrid was characterized by powder X-ray diffraction (PXRD) to study intercalation, scanning electron microscopy (SEM) for the investigation of surface morphology, Fourier transform infrared (FTIR) spectrophotometer to study the chemical interactions and thermal gravimetric analysis/derivative thermogravimetric analysis (TGA/DTG) for understanding the thermal stability. The PXRD patterns showed that the IBU was successfully intercalated into the interlay space of LZHs as monolayers and the basal spacing of LZH increased from 9.57 to 19.54 Å. The FTIR analyses confirmed the formation of the host-guest nanohybrid. The DTG studies revealed that the thermal stability of IBU was increased after the intercalation into LZH. The in vitro release study of IBU from IBU-LZH and IBU-LZH/chitosan nanocomposite was investigated in phosphate buffer saline (PBS) solution of pH 4.8 and 7.4. The drug release from the LZH was studied by ultraviolet-visible (UV-vis) spectroscopy.

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Direct Control of Drug Release Behavior from Layered Double Hydroxides through Particle Interactions

Cited by 80 publications

References 44 publications

Study on the release behavior and mechanism by monitoring the morphology changes of the large-sized drug-LDH nanohybrids

Study on the release behavior and mechanism by monitoring the morphology changes of the large-sized drug-LDH nanohybrids

Biomedical Applications of Layered Double Hydroxides

Layered zinc hydroxide–ibuprofen nanohybrids: synthesis and characterization

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