2018
DOI: 10.3390/s18072214
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Direct Detection of Candida albicans with a Membrane Based Electrochemical Impedance Spectroscopy Sensor

Abstract: Candidemia and invasive candidiasis is a cause of high mortality and morbidity rates among hospitalized patients worldwide. The occurrence of the infections increases due to the complexity of the patients and overuse of the antifungal therapy. The current Candida detection method includes blood culturing which is a lengthy procedure and thus delays the administration of the antifungal therapy. Even though the results are available after 48 h it is still the gold standard in pathogen detection in a hospital set… Show more

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Cited by 19 publications
(14 citation statements)
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“…This labeled proof-of-concept assay is only applicable for artificially derived GFP expressing yeasts; still, for wild-type strains, this approach could be potentially extended by employing fluorescently labeled antibodies or peptide nucleic acid-based fluorescence in situ hybridization. [125,126] While only a handful of works demonstrated microfluidicassisted identification of fungal species, there are numerous biosensing systems for fungal pathogens detection [127][128][129][130] which…”
Section: Step 2: Microfluidics For Fungal Pathogen Detection and Identificationmentioning
confidence: 99%
“…This labeled proof-of-concept assay is only applicable for artificially derived GFP expressing yeasts; still, for wild-type strains, this approach could be potentially extended by employing fluorescently labeled antibodies or peptide nucleic acid-based fluorescence in situ hybridization. [125,126] While only a handful of works demonstrated microfluidicassisted identification of fungal species, there are numerous biosensing systems for fungal pathogens detection [127][128][129][130] which…”
Section: Step 2: Microfluidics For Fungal Pathogen Detection and Identificationmentioning
confidence: 99%
“…The developed sensor showed high sensitivity and specificity towards Candida albicans providing rapid and accurate detection in less than 1 hour. Future work requires optimization of the sensor functionalization protocol to ensure more reliable target binding [22] . EphA2-deficient mice demonstrated reduced inflammatory responses and IL-17 signalling, resulting in severe disease.…”
Section: Diagnosismentioning
confidence: 99%
“…Despite the potential and multiple advantages of electrochemical methods, a limited number of publications have so far reported on their application for fungal diagnosis. Direct detection of C. albicans has been achieved using membrane based electrochemical impedance spectroscopy [ 123 ]. A sensor electrode primed with anti- Candida antibodies appeared to have a detection sensitivity of 10 CFU/mL.…”
Section: Working Principal Of Biosensorsmentioning
confidence: 99%