Direct detection of the anti‐cancer drug 9‐phenylacridine in tissues by graphite rod laser desorption vacuum‐ultraviolet post‐ionization mass spectrometry

Liu, Ping; Hu, Yongjun; Chen, Jiaxin; Yang, Qing

doi:10.1002/rcm.7226

Cited by 10 publications

(4 citation statements)

References 51 publications

(93 reference statements)

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“…The DESI MS method is direct and rapid in providing molecular detail of the surfaces studied; however, it requires the development and optimization of novel ionization strategies for the ionization of tough ionizing molecules. LDI MS techniques have evolved to use nanomaterials to assist in fine-tuning the technique [103][104][105][106][107][108]; applications of this technique could certainly prove beneficial with respect to MP detection. MS-based techniques are still confronting reproducibility issues and lapses in quantification methodologies-these need to be overcome in order to fully utilize these techniques.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Chun

Muthu²,

Gopal³

2022

Chemosensors

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Plastic particles smaller than 5 mm accumulate in aqueous, terrestrial, and atmospheric environments and their discovery has been a serious concern when it comes to eco-toxicology and human health risk assessment. In the following review, the potential of mass spectrometry (MS) for the detection of microplastic (MP) pollutants has been elaborately reviewed. The use of various mass spectrometric techniques ranging from gas chromatography–mass spectrometry (GC-MS), liquid chromatographic mass spectrometric (LC-MS) to matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), including their variants, have been reviewed. The lapses in the detection system have been addressed and future recommendations proposed. The challenges facing microplastics and their detection have been discussed and future directions, including mitigation methods, have been presented.

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Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Chun

Muthu²,

Gopal³

2022

Chemosensors

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“…Quantitative analysis showed that the present methodology was available to MB of ~0.1 nmol in the mouse kidney slice. A similar L2MS system with a few modifications to the vacuum chamber was later applied to detecting an anticancer drug 9‐phenylacridine in the kidney of mice (Liu et al, 2015) and proflavine in rat whole blood (Chen et al, 2017a), indicating the potential of VUV L2MS in pharmacokinetic study.…”

Section: L2ms In Bioapplicationsmentioning

confidence: 99%

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

Ding

Liu

Shi

2020

Mass Spectrometry Reviews

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Lasers have long been used in the field of mass spectrometric analysis for characterization of condensed matter. However, emission of neutrals upon laser irradiation surpasses the number of ions. Typically, only one in about one million analytes ejected by laser desorption/ablation is ionized, which has fueled the quest for postionization methods enabling ionization of desorbed neutrals to enhance mass spectrometric detection schemes. The development of postionization techniques can be an endeavor that integrates multiple disciplines involving photon energy transfer, electrochemistry, gas discharge, etc. The combination of lasers of different parameters and diverse ion sources has made laser desorption/ablation postionization (LD/API) a growing and lively research community, including two‐step laser mass spectrometry, laser ablation atmospheric pressure photoionization mass spectrometry, and those coupled to ambient mass spectrometry. These hyphenated techniques have shown potentials in bioanalytical applications, with major inroads to be made in simultaneous location and quantification of pharmaceuticals, toxins, and metabolites in complex biomatrixes. This review is intended to provide a timely comprehensive view of the broadening bioanalytical applications of disparate LD/API techniques. We also have attempted to discuss these applications according to the classifications based on the postionization methods and to encapsulate the latest achievements in the field of LD/API by highlighting some of the very best reports in the 21st century. © 2020 John Wiley & Sons Ltd.

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“…Numerous analytical techniques have been employed in forensic laboratories to comprehensively analyse a broad range of drugs in complex samples, usually based on the separation techniques gas chromatography-mass spectrometry (GC-MS) [1] and liquid chromatography-mass spectrometry (LC-MS), although direct MS analysis approaches have also been proposed, where the sample is analysed directly by the use of MS without prior chromatographic separation [2,3]. GC-MS has proven to be a reliable technique for drug analysis because of its high selectivity, sensitivity and the possibility of positive identification provided by drug MS libraries.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Analysis of Drugs in Forensic Cases by Liquid Chromatography–High-Resolution Orbitrap Mass Spectrometry

et al. 2019

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In the present study, liquid chromatography coupled to an Orbitrap mass spectrometer (HPLC-Q-Orbitrap MS) was used as an approach for identification and quantification of 113 drugs simultaneously in biological samples (whole blood/plasma/ serum). Samples were prepared using liquid-liquid extraction conducted using a trizma/isopropanol/butyl chloride buffer system. Reversed-phase separation employing a column (50 × 2.1 mm) packed with 2.6-μm C18 particles was then performed under gradient elution with mobile phase composition consisting of acetic acid and aqueous-acetonitrile mixtures with the acetonitrile content ranging from 10 to 100% v/v. Compounds were detected with high-resolution MS operated in full scan mode having a mass accuracy < 5 ppm. In this study, isobaric compounds (same nominal mass) were easily distinguished and identified by their different retention times. Extracted ion chromatograms (XICs) with narrow mass tolerance window (5 ppm) provided analysis with acceptable linearity (r 2 ) ranged from 0.9530 to 1, low limits of detection (LOD) (0.02-39 ng mL −1 ) and low limit of quantification (LOQ) (0.1-130 ng mL −1 ). The developed method was applied to successfully analyse drugs in 26 blood samples from positive forensic cases and proved that this technique was able to detect analytes at trace level.

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Direct detection of the anti‐cancer drug 9‐phenylacridine in tissues by graphite rod laser desorption vacuum‐ultraviolet post‐ionization mass spectrometry

Cited by 10 publications

References 51 publications

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Mass Spectrometry as an Analytical Tool for Detection of Microplastics in the Environment

Laser Desorption/Ablation Postionization Mass Spectrometry: Recent Progress in Bioanalytical Applications

Simultaneous Analysis of Drugs in Forensic Cases by Liquid Chromatography–High-Resolution Orbitrap Mass Spectrometry

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