Direct determination of heavy elements in biological media by spark source mass spectrometry

Fitchett, Arthur W.; Buck, Richard P.; Mushak, Paul

doi:10.1021/ac60342a049

Cited by 20 publications

(4 citation statements)

References 8 publications

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“…The technique of IMS relies on separating gaseous ions according to their mobility through a drift-tube filled with a buffer gas [18]. Ions are accelerated through the drift tube by an electric field, wherein ions of differing shapes have different mobilities depending on an ion's characteristic collision cross-section (CCS).…”

Section: Background To Esi–ims–ms Development and Application To Biolmentioning

confidence: 99%

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly

Woods

Radford

Ashcroft

2013

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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Interfacing ion mobility spectrometry to mass spectrometry (IMS–MS) has enabled mass spectrometric analyses to extend into an extra dimension, providing unrivalled separation and structural characterization of lowly populated species in heterogeneous mixtures. One biological system that has benefitted significantly from such advances is that of amyloid formation. Using IMS–MS, progress has been made into identifying transiently populated monomeric and oligomeric species for a number of different amyloid systems and has led to an enhanced understanding of the mechanism by which small molecules modulate amyloid formation. This review highlights recent advances in this field, which have been accelerated by the commercial availability of IMS–MS instruments. This article is part of a Special Issue entitled: Mass spectrometry in structural biology.

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Section: Background To Esi–ims–ms Development and Application To Biolmentioning

confidence: 99%

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly

Woods

Radford

Ashcroft

2013

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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“…1-2 In its initial use, resolving power was a qualitative metric used to compare the relative capabilities of one ion mobility technique or instrument to another. Following the commercialization and development of ambient pressure, uniform field ion mobility spectrometry (IMS) in the 1970s, 3-5 there were several attempts at quantifying the IMS separation efficiency including the use of theoretical plate numbers, 6 two-peak resolution, 8-9 and single-peak resolving power. 7,10-11 Of these, the single peak resolving power was widely adopted and is currently the conventional means by which the separation efficiency of IMS is quantified.…”

Section: Introductionmentioning

confidence: 99%

Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer

May

Dodds

Kurulugama

et al. 2015

Analyst

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An extensive study of two current ion mobility resolving power theories (“conditional” and “semi-empirical”) was undertaken using a recently developed drift tube ion mobility-mass spectrometer. The current study investigates the quantitative agreement between experiment and theory at reduced pressure (4 Torr) for a wide range of initial ion gate widths (100 to 500 µs), and ion mobility values (K0 from 0.50 to 3.0 cm2/V·s) representing measurements obtained in helium, nitrogen, and carbon dioxide drift gas. Results suggest that the conditional resolving power theory deviates from experimental results for low mobility ions (e.g., high mass analytes) and for initial ion gate widths beyond 200 µs. A semi-empirical resolving power theory provided close-correlation of predicted resolving powers to experimental results across the full range of mobilities and gate widths investigated. Interpreting the results from the semi-empirical theory, the performance of the current instrumentation was found to be highly linear for a wide range of analytes, with optimal resolving powers being accessible for a narrow range of drift fields between 14 and 17 V/cm. While developed using singly-charged ion mobility data, preliminary results suggest that the semi-empirical theory has broader applicability to higher-charge state systems.

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“…These results later proved to be the basis for the governing principles of ion mobility spectrometry (IMS). The instrumentation, however, took almost 70 years to be first developed under the name of Plasma Chromatography 4 , a gas phase electrophoretic analytic technique 5-7 in which the ionization source was similar to that employed in an electron capture detector and the sample chamber was designed for the continuous introduction of organic compounds of high purity.…”

Section: Origin and Applicationsmentioning

confidence: 99%

Review on Ion Mobility Spectrometry. Part 1: current instrumentation

Cumeras

Figueras

Davis

et al. 2015

Analyst

387

312

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Ion Mobility Spectrometry (IMS) is a widely used and ‘well-known’ technique of ion separation in gaseous phase based on the differences of ion mobilities under an electric field. All IMS instruments operate with an electric field that provides space separation, but some IMS instruments also operate with a drift gas flow which provides also a temporal separation. In this review we will summarize the current IMS instrumentation. IMS techniques have received an increased interest as new instrumentation has become available to be coupled with mass spectrometry (MS). For each of the eight types of IMS instruments reviewed it is mentioned whether they can be hyphenated with MS and whether they are commercially available. Finally, out of the described devices, the six most-consolidated ones are compared. The current review article is followed by a companion review article which details the IMS hyphenated techniques (mainly gas chromatography and mass spectrometry) and the factors that make the data from an IMS device change as function of device parameters and sampling conditions. These reviews will provide the reader with an insightful view of the main characteristics and aspects of the IMS technique.

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Direct determination of heavy elements in biological media by spark source mass spectrometry

Cited by 20 publications

References 8 publications

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly

Advances in ion mobility spectrometry–mass spectrometry reveal key insights into amyloid assembly

Broadscale resolving power performance of a high precision uniform field ion mobility-mass spectrometer

Review on Ion Mobility Spectrometry. Part 1: current instrumentation

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