Direct determination of selenium in human serum by inductively coupled plasma-collision cell-mass spectrometry

Burri, Judith; Haldimann, Max

doi:10.1515/cclm.2007.153

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…Compared to other body fluids, urine is easy to access and analyze. Moreover, the Se-related metabolites in urine such as Se-methylselenogalactosamine, selenosugars, and trimethylselenium are helpful to understand the health benefits ascribed to this element. − Numerous techniques have been developed to determine selenium concentration in urine. ,, …”

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confidence: 99%

Hydride Generation for Headspace Solid-Phase Extraction with CdTe Quantum Dots Immobilized on Paper for Sensitive Visual Detection of Selenium

Huang

Zhu

et al. 2015

Anal. Chem.

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/npsi/ctrl?action=rtdoc&an=21277457&lang=en http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/ctrl?action=rtdoc&an=21277457&lang=fr READ THESE TERMS AND CONDITIONS CAREFULLY BEFORE USING THIS WEBSITE.http://nparc.cisti-icist.nrc-cnrc.gc.ca/npsi/jsp/nparc_cp.jsp?lang=en Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca.

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mentioning

confidence: 99%

Hydride Generation for Headspace Solid-Phase Extraction with CdTe Quantum Dots Immobilized on Paper for Sensitive Visual Detection of Selenium

Huang

Zhu

et al. 2015

Anal. Chem.

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“…Sample preparation was modified from that described by Burri and Haldimann. 38 Briefly, a diluent containing 4% isopropanol, 0.1% EDTA, 0.1% Triton X-100 and 2% NH 4 OH was prepared. Te was added to this solution as the internal standard to a final concentration of 0.130 µmol L −1 in the sample.…”

Section: Sample Preparationmentioning

confidence: 99%

“…To facilitate desirable in-cell reactions, a low negative voltage OctP bias accelerated ions into the cell, and a slight positive bias limited in-cell products from exiting the cell, providing more time for reaction. Tune mode 2 used an H 2 flow rate of 5.0 mL min −1 (standard conditions for Se determination, to reduce the 40 Ar 38 Ar + dimer at m/z 78), and tune mode 3 used a higher flow rate (9.0 mL min −1 ), determined experimentally as the optimal rate to reduce 156 Gd ++ interference on m/z 78, whilst maintaining adequate sensitivity for 78 Se + (Fig. 1).…”

Section: Collision/reaction Conditionsmentioning

confidence: 99%

Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS

Bishop

Hare

Fryer

et al. 2015

Analyst

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Gadolinium (Gd)-based magnetic resonance imaging (MRI) contrasting agents interfere with the determination of selenium (Se) when analysed by single quadrupole inductively coupled plasma-mass spectrometry (ICP-MS). This paper demonstrates that an ICP-triple quadrupole-MS (ICP-QQQ-MS) with oxygen mass shift overcomes Gd(++) interference on Se(+) and mitigates typically encountered matrix and spectral based interferences. Normal human serum was diluted in a solution containing isopropanol, EDTA, NH4OH and Triton X-100. Samples were unspiked (control) serum; serum spiked with 0.127 μmol L(-1) Se or 127 μmol L(-1) Gd; and serum spiked with both 0.127 μmol L(-1) Se and 127 μmol L(-1) Gd. Consideration of collision/reaction gases and conditions for interference mitigation included helium (He); a 'low' and 'high' hydrogen (H2) flow, and oxygen (O2). The instrument tune for O2 was optimised for effective elimination of interferences via a mass shift reaction of Se(+) to SeO(+). The ICP-QQQ-MS was capable of detecting trace (>9.34 nmol L(-1)) levels of Se in serum in the presence of Gd in our simulated post-MRI serum sample. The multi-tune capabilities of the ICP-QQQ-MS may be adapted to eliminate other specific isobaric interferences that cause false positive results in other analyses where the analyte is confounded by doubly charged and/or polyatomic species.

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“…The regulation of gene expression of SeBPs is unknown 98 . The SeBP levels may be correlated with inhibition of DNA synthesis in mammary epithelial cells 98 .…”

Section: Selenoproteins In Vertebratesmentioning

confidence: 99%

“…However, this method is not free of mass interferences therefore, the correction of the signal intensity of the dead time and the mass bias has to done before the analysis of sample before the measurement 93,94,95,96 . In the case of selenium determination, the ICP -MS system is equipped with the collision/reaction cell in order to avoid the spectroscopic interferences of plasma on the major isotopes of selenium 97,98 .…”

Section: Quality Control In Lc -Ms Analysismentioning

confidence: 99%

Method development for selenium speciation analysis in biological samples by using HPLC with atomic and molecular MS

Lü¹

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Chapter 6. Conclusion 6.1 Determination of selenium content in biological samples by ICP -MS…………………………………………………………………………………..255 6.2 Selenium speciation of Se compounds/metabolites in urine and liver samples 6.2.1 Selenium speciation analysis of the four relevant human urinary selenium species: TMSe + , SeMet, SeGalNAc and SeGluNAc by HPLC -ICP -MS and HPLC -API -MS/MS……………………………………………………………………..255 6.2.2 Application of HPLC -ICP -MS and HPLC -APCI -MS/MS for selenium speciation in cytosolic samples of porcine liver…………………………………….256 6.2.3 The boundary of HPLC -ICP -MS and HPLC -API -MS/MS techniques...256 XIII 6.3 HPLC separation and mass spectrometric characterisations of Se-containing tocopherol and tocotrienol succinate derivative compounds…………………...257 6.4 Further considerations on the selenium speciation in biological samples 6.4.1 Further considerations on the selenium speciation in biological samples……258 6.4.2 Aspects for future studies……………………………………………………..259 Reference…………………………………………………………………………..261 XIV Appendix Appendix 1 1.1 Total selenium contents in food products in the local market (Crete, Greece)…263 1.2 General information on mammalian selenoproteins……………………………266 1.3 Selenium species of biological interests………………………………………..268 Reference…………………………………………………………………………...273 Appendix 2 2.1 Variety of biological specimens relevant to the diverse biochemical events in mammal body……………………………………………………………………….277 2.2 Reversed phase columns for highly aqueous mobile phase (or, for the separation of highly polar/hydrophilic compounds)……………………………………………278 2.3. Technical perspectives on capillary/nano liquid chromatography and nanoelectrospray ionization mass spectrometry…………………………………….279 Reference…………………………………………………………………………...286 Appendix 3 3.1 Supplemental HPLC parameters used in this study…………………….………289 3.2 Supplemental figures for chapter 3………………………………………….….292 3.3 ESI-MS and ESI-MS/MS of molecular ions of TMSe + and SeMet and their corresponding product ions of in this study………………………………………...300 3.4 Proposed fragmentation pathways for TMSe + , SeMet, SeGalNAc and SeGluNAc, and supplemental information obtained using multistage ion trap mass spectrometry………………………………………………………………………...303 3.5. Isobaric interferences in Se determination by ICP-MS………………………...307 3.6 Recovery of PerfectSil Target 100 C 8 -3 column (150 × 4.0 mm, 5 µm, Analysentechnik, Germany)………………………………………………………...308 3.7 Comparison of the signal and background levels in APCI -SRM and ESI -SRM determination of SeMet, SeGalNAc and SeGluNAc standards…………………….309 3.8 Supplemental data on determination of total selenium concentration in biological samples by ICP-MS…………………………………………………………………310 XV 3.9 Comparison of signal intensity of ESI-MS/MS detection of four selenium species separated respectively in two reversed phase columns……………………………..313 3.10 Quantification of TMSe + in crude human urine sample by HPLC-ESI-MS/MS……………………………………………………………………………...314 3.11 Quantification of SeGalNAc in crude human urine sample by HPLC-ESI-MS/MS………………………...

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Direct determination of selenium in human serum by inductively coupled plasma-collision cell-mass spectrometry

Abstract: The benefits of the new method are high accuracy combined with low sample consumption and fast sample throughput.

Cited by 5 publications

References 15 publications

Hydride Generation for Headspace Solid-Phase Extraction with CdTe Quantum Dots Immobilized on Paper for Sensitive Visual Detection of Selenium

Hydride Generation for Headspace Solid-Phase Extraction with CdTe Quantum Dots Immobilized on Paper for Sensitive Visual Detection of Selenium

Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS

Method development for selenium speciation analysis in biological samples by using HPLC with atomic and molecular MS

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