Direct Effects of Statins on Cells Primarily Involved in Atherosclerosis.

Chen, Hong; Ikeda, Uichi; Shimpo, Masahisa; Shimada, Kazuyuki

doi:10.1291/hypres.23.187

Cited by 36 publications

(17 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to their cholesterol-lowering properties, statins exert pleiotropic effects that include improvement of endothelium function, anti-inflammatory, antithrombotic, and immunomodulatory effects [8,9]. Although statins have consistently been found to have important effects on vascular function, attenuation of vascular function by early withdrawal of therapy was initially described in relatively few studies [10,11].…”

Section: Introductionmentioning

confidence: 99%

Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose–response effect dependent on endothelial nitric oxide synthase

Chen¹,

Ren²,

Xing³

et al. 2009

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose–response effect dependent on endothelial nitric oxide synthase

Chen¹,

Ren²,

Xing³

et al. 2009

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

“…1,2 Recent studies have indicated that statins have pleiotropic effects on the atherogenic process, including an anti-inflammatory effect. 3 On the other hand, proinflammatory cytokines, such as tumor necrosis factor (TNF)-a, interleukin (IL)-1, and IL-6, have profound effects on lipid metabolism. 4 These findings suggest that there are complex interactions between inflammation and lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice

et al. 2004

View full text Add to dashboard Cite

Inflammation is a major contributor to atherosclerosis by its effects on arterial wall biology and lipoprotein metabolism. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that may modulate the atherosclerotic disease process. We investigated the effects of adeno-associated virus (AAV) vector-mediated gene transfer of IL-10 on atherogenesis in apolipoprotein E (ApoE)-deficient mice. A murine myoblast cell line, C2C12, transduced with AAV encoding murine IL-10 (AAV2-mIL10) secreted substantial amounts of IL-10 into conditioned medium. The production of monocyte chemoattractant protein-1 (MCP-1) by the murine macrophage cell line, J774, was significantly inhibited by conditioned medium from AAV2-mIL10-transduced C2C12 cells. ApoE-deficient mice were injected with AAV5-mIL10 into their anterior tibial muscle at 8 weeks of age. The expression of MCP-1 in the vascular wall of the ascending aorta and serum MCP-1 concentration were decreased in AAV5-mIL10-transduced mice compared with AAV5-LacZ-transduced mice. Oil red-O staining of the ascending aorta revealed that IL-10 gene transfer resulted in a 31% reduction in plaque surface area. Serum cholesterol concentrations were also significantly reduced in AAV5-mIL10-transduced mice. To understand the cholesterol-lowering mechanism of IL-10, we measured the cellular cholesterol level in HepG2 cells, resulting in its significant decrease by the addition of IL-10 in a dosedependent manner. Furthermore, IL-10 suppressed HMGCoA reductase expression in the HepG2 cells. These observations suggest that intramuscular injection of AAV5-mIL10 into ApoE-deficient mice inhibits atherogenesis through anti-inflammatory and cholesterol-lowering effects.

show abstract

“…Some statins have been demonstrated to inhibit the proliferation of vascular smooth muscle cells and to increase endothelial NO production independently of their cholesterol-reducing effects (35). Atorvastatin has been reported to reduce free radical release from the rat aorta (36).…”

Section: Discussionmentioning

confidence: 99%

Effects of Cholesterol-Lowering Therapy on Pressor Hyperreactivity to Stress in Hypercholesterolemic Patients

Minami¹,

Atarashi²,

Ishiyama³

et al. 2003

Hypertens Res

View full text Add to dashboard Cite

Direct Effects of Statins on Cells Primarily Involved in Atherosclerosis.

Cited by 36 publications

References 57 publications

Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose–response effect dependent on endothelial nitric oxide synthase

Short-term withdrawal of simvastatin induces endothelial dysfunction in patients with coronary artery disease: A dose–response effect dependent on endothelial nitric oxide synthase

Adeno-associated virus vector-mediated interleukin-10 gene transfer inhibits atherosclerosis in apolipoprotein E-deficient mice

Effects of Cholesterol-Lowering Therapy on Pressor Hyperreactivity to Stress in Hypercholesterolemic Patients

Contact Info

Product

Resources

About