Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism

Mieszkowski, Jan; Brzezińska, Paulina; Stankiewicz, Błażej; Kochanowicz, Andrzej; Niespodziński, Bartłomiej; Proczko-Stepaniak, Monika; Waldziński, Tomasz; Kacprzak, Bartłomiej; Siuba-Jarosz, Natalia; Petr, Michal; Antosiewicz, Jędrzej

doi:10.3390/nu14214485

Cited by 10 publications

(10 citation statements)

References 29 publications

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“…It was also an interesting observation that the level of quinolinic acid was affected in winter MS, which is also the season when we found a drop in vitD levels. In a recent study, the effect of vitD on levels of kynurenine pathway metabolites, quinolinic acid, and kynurenic acid, was demonstrated [ 89 ]. The authors showed that vitD supplements reduced production of both metabolites.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse

Мартынова

Хайбуллин²,

Салафутдинов

et al. 2023

IJMS

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Multiple sclerosis (MS) is a debilitating chronic disease of unknown etiology. There are limited treatment options due to an incomplete understanding of disease pathology. The disease is shown to have seasonal exacerbation of clinical symptoms. The mechanisms of such seasonal worsening of symptoms remains unknown. In this study, we applied targeted metabolomics analysis of serum samples using LC-MC/MC to determine seasonal changes in metabolites throughout the four seasons. We also analyzed seasonal serum cytokine alterations in patients with relapsed MS. For the first time, we can demonstrate seasonal changes in various metabolites in MS compared to the control. More metabolites were affected in MS in the fall season followed by spring, while summer MS was characterized by the smallest number of affected metabolites. Ceramides were activated in all seasons, suggesting their central role in the disease pathogenesis. Substantial changes in glucose metabolite levels were found in MS, indicating a potential shift to glycolysis. An increased serum level of quinolinic acid was demonstrated in winter MS. Histidine pathways were affected, suggesting their role in relapse of MS in the spring and fall. We also found that spring and fall seasons had a higher number of overlapping metabolites affected in MS. This could be explained by patients having a relapse of symptoms during these two seasons.

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Section: Discussionmentioning

confidence: 99%

Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse

Мартынова

Хайбуллин²,

Салафутдинов

et al. 2023

IJMS

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“…Vitamin D modulates changes in kynurenine metabolism induced by endurance exercise [ 28 ]. However, it is essential to note that Trp can also be metabolised to 5-hydroxy-tryptamine (serotonin).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation Influences Ultramarathon-Induced Changes in Serum Amino Acid Levels, Tryptophan/Branched-Chain Amino Acid Ratio, and Arginine/Asymmetric Dimethylarginine Ratio

et al. 2023

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Exercise affects serum levels of amino acids and their metabolites, with important metabolic consequences. Since vitamin D impacts skeletal muscle protein degradation, we hypothesised that it would also impact exercise-induced changes in serum amino acid levels and the serum levels of arginine metabolites, influencing the body’s ability to synthesise NO. Accordingly, we analysed the effect of a single high-dose vitamin D supplementation on the serum levels of various amino acids in ultramarathon runners. Thirty-five male amateur runners were assigned to the supplemented group, administered 150,000 IU vitamin D in vegetable oil 24 h before the run (n = 16), or the control (placebo) group (n = 19). Blood was sampled 24 h before, immediately after, and 24 h after the run. Changes in the serum levels of some amino acids were distinct in the two groups. The asymmetric dimethyl arginine levels were significantly decreased immediately after the run and increased 24 h later and were not affected by the supplementation. The symmetric dimethyl arginine levels were increased after the run in both groups but were lower in the supplemented group than in the placebo group 24 h after the run. The dimethylamine levels increased significantly in the supplemented group as compared to the placebo group. In conclusion, vitamin D impacts exercise-induced changes in serum amino acids and methylated arginine metabolites.

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“…1). By means of kynurenine aminotransferase II, KYN directly transforms into KYNA [16] (Fig. 1 and 2).…”

Section: Roles Of Kynurenine (Kyn) and Kynurenic Acid (Kyna)mentioning

confidence: 99%

Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis

Xie,

Wu,

et al. 2024

Aging and disease

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Alzheimer's disease (AD) is an age-dependent neurodegenerative disease characterized by extracellular Amyloid Aβ peptide (Aβ) deposition and intracellular Tau protein aggregation. Glia, especially microglia and astrocytes are core participants during the progression of AD and these cells are the mediators of Aβ clearance and degradation. The microbiota-gut-brain axis (MGBA) is a complex interactive network between the gut and brain involved in neurodegeneration. MGBA affects the function of glia in the central nervous system (CNS), and microbial metabolites regulate the communication between astrocytes and microglia; however, whether such communication is part of AD pathophysiology remains unknown. One of the potential links in bilateral gut-brain communication is tryptophan (Trp) metabolism. The microbiota-originated Trp and its metabolites enter the CNS to control microglial activation, and the activated microglia subsequently affect astrocyte functions. The present review highlights the role of MGBA in AD pathology, especially the roles of Trp per se and its metabolism as a part of the gut microbiota and brain communications. We (i) discuss the roles of Trp derivatives in microglia-astrocyte crosstalk from a bioinformatics perspective, (ii) describe the role of glia polarization in the microglia-astrocyte crosstalk and AD pathology, and (iii) summarize the potential of Trp metabolism as a therapeutic target. Finally, we review the role of Trp in AD from the perspective of the gut-brain axis and microglia, as well as astrocyte crosstalk, to inspire the discovery of novel AD therapeutics.

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Direct Effects of Vitamin D Supplementation on Ultramarathon-Induced Changes in Kynurenine Metabolism

Cited by 10 publications

References 29 publications

Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse

Seasonal Changes in Serum Metabolites in Multiple Sclerosis Relapse

Vitamin D Supplementation Influences Ultramarathon-Induced Changes in Serum Amino Acid Levels, Tryptophan/Branched-Chain Amino Acid Ratio, and Arginine/Asymmetric Dimethylarginine Ratio

Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis

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