Direct Electrochemical Synthesis of Metal Complexes

Puente, Carlos; López, Israel

doi:10.1016/b978-0-12-811061-4.00003-7

Cited by 9 publications

(3 citation statements)

References 115 publications

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“…[ 5 ] The electrical synthesis of metal ion complexes is of great importance due to its promising results. [ 6 ] This electrical method has many useful features, starting with synthesis that occurs in moderate conditions, short times, low cost, and ends with high yields. [ 7 ] This method [ 8 ] has previously been shown to assemble a hexamine Pt(IV) complex, after the platinum electrode has dissolved in the electrochemical cell.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical synthesis for new thiosemicarbazide complexes, spectroscopy, cyclic voltammetry, structural properties, and in silico study

Refat

El‐Metwaly

Yamany

et al. 2020

Applied Organom Chemis

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A new thiosemicarbazide derivative ligand (HDCTS) was prepared from the reaction between 2,4-dinitrophenylhydrazine and 4-chlorophenyl isothiocyanate. Co(II) and Cu(II) complexes were synthesized from HDCTS derivative by electrochemical method to reach preferable yield in a safe environment. The new complexes as well as the original ligand were fully characterized to establish their chemical formulae. The spectral (infrared, Raman, mass, and ultraviolet-visible), analytical (elemental, thermogravimetric analysis [TGA], and cyclic voltammetry), and conformational techniques were implemented for characterization. According to spectral data and magnetic moments, the octahedral arrangement was proposed around metals through mono-negative bidentate mode of bonding. TGA discriminates and quantitatively evaluates the presence of water molecules within two complexes. Electrochemical study was interested for all new compounds and suggests the electrode couples to be close for quasi-reversible behavior. Elaborated conformational study was displayed to extract significant characteristics, which assert firstly on the mode of bonding inside the complexes. The perfect distribution of NH and CS groups inside the optimized structures facilitates their coordination as spectrally proposed. Crystal explorer program was used to investigate the degree of contact between molecules inside crystal packing systems. Effective contribution in surface contact feature was noticed from O and Cl atoms. A certified in silico study concerning the docking feature of new compounds against effective proteins in allergy and inflammation diseases was done. According to data exported, a promising anti-allergic or anti-inflammatory efficiency is expected strongly from Cu(II)-DCTS complex.

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Section: Introductionmentioning

confidence: 99%

Electrochemical synthesis for new thiosemicarbazide complexes, spectroscopy, cyclic voltammetry, structural properties, and in silico study

Refat

El‐Metwaly

Yamany

et al. 2020

Applied Organom Chemis

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“…Electrochemical synthesis is a powerful technique for the synthesis of a broad spectrum of organic 1-7 and inorganic compounds. [8][9][10][11][12][13][14] In this way, electrochemical synthesis using sacricial anodes is an interesting research eld with a wide range of potential applications which has received much attention in recent years. [15][16][17][18] One of the most important applications of sacricial anodes is their use in the synthesis of metallic complexes.…”

Section: Introductionmentioning

confidence: 99%

Green electrochemical synthesis of silver sulfadiazine microcrystals

2019

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Electrochemical synthesis of silver sulfadiazine (AgSD) microcrystals was carried out galvanostatically in a special two-electrode cell equipped with a sacrificial silver rod anode and a stainless steel plate cathode. The cell used in this work consists of a small cylindrical chamber containing aqueous sulfadiazine/sodium nitrate as the anode compartment inside a larger cylindrical chamber containing nitric acid solution as the cathode compartment.The ionic connection of two chambers is carried out through a solvent surface layer. In this study, the effect of the experimental parameters such as applied current density and sodium nitrate concentration as well as nitric acid concentration on the yield and energy consumption of AgSD is discussed. The proposed method is fast and green and has unique features including synthesis in a single step, and no need for a metal salt.

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“…23 In electrochemical complexation using a sacrificial anode, metal ions are produced directly from the oxidation of the anode and react with the ligand present in the cell. [24][25][26] In addition to the essential role of metal ions in biological systems, they are used to treat many diseases. Therefore, the complexation of drugs with metal ions may increase and diversify their medicinal properties.…”

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confidence: 99%

Green Electrochemical Complexation of Fluconazole, Itraconazole, Voriconazole, Ketoconazole and Clotrimazole with Silver, Copper and Zinc Cations

Godini,

Nematollahi,

Zivari-Moshfegh

2023

J. Electrochem. Soc.

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Electrochemical complexation of azole antifungal drugs fluconazole, itraconazole, ketoconazole, voriconazole, and clotrimazole with silver, copper, and zinc cations was carried out galvanostatically in an undivided electrolytic cell equipped with a sacrificial anode under green conditions. In this work, we synthesized 20 different complexes of these drugs by a simple method in water (containing a strong acid)/ethanol mixtures with high yield (average 67%) and purity. The effective synthetic parameters, including the applied current, electricity consumption, acid concentration, cell voltage, energy consumption, and cell design were optimized. Our results indicate that the applied current and acid concentration have no significant effects on the yield and purity of azole complexes. But these factors have a significant effect on cell voltage and energy consumption in such a way that by increasing the applied current or decreasing the acid concentration, the cell voltage and energy consumption increase. Fourier transform infrared spectroscopy, field-emission scanning electron microscopy and energy-dispersive X-ray techniques have been used for the characterization of synthesized complexes. In addition, cyclic voltammetry analysis has been used to investigate the reaction mechanism. This method provides an efficient and green strategy for the complexation of azole drugs in one step without the need for metal salts.

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Direct Electrochemical Synthesis of Metal Complexes

Cited by 9 publications

References 115 publications

Electrochemical synthesis for new thiosemicarbazide complexes, spectroscopy, cyclic voltammetry, structural properties, and in silico study

Electrochemical synthesis for new thiosemicarbazide complexes, spectroscopy, cyclic voltammetry, structural properties, and in silico study

Green electrochemical synthesis of silver sulfadiazine microcrystals

Green Electrochemical Complexation of Fluconazole, Itraconazole, Voriconazole, Ketoconazole and Clotrimazole with Silver, Copper and Zinc Cations

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