Direct encapsulation of proteins into calcium silicate microparticles by water/oil/water interfacial reaction method and their responsive release behaviors

Fujiwara, Masahiro; Shiokawa, Kumi; Kubota, Tomijiro

doi:10.1016/j.msec.2012.07.030

Cited by 16 publications

(10 citation statements)

References 49 publications

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“…The loading efficiencies of big and small particles are comparable which proves a deep internalization of the drug into the calcium carbonate matrix, a factor of 6 between small and big particle loading would reflect an adsorption only to the external surface. These efficiencies are in the same order as those of other substances loaded via adsorption into porous carriers [8,27,28]. Scanning electron microscopy images and two-photon fluorescent images of the loaded particles are presented in Fig.…”

Section: Particle Loadingsupporting

confidence: 52%

Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer

Svenskaya

Parakhonskiy

Haase

et al. 2013

Biophysical Chemistry

168

136

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In photodynamic therapy (PDT), photosensitizers are required to arrive in high concentrations at selective targets like cancer cells avoiding toxicity in healthy tissue. In this work, we propose the application of porous calcium carbonate carriers in the form of polycrystalline vaterite for this task. We investigated the loading efficiency for the photosensitizer Photosens in vaterite micro- and nanocarriers. A possible release mechanism depending on the surrounding pH was studied, showing a fast degradation of the carriers in buffers below pH7. These results hold out the prospect of a novel PDT drug delivery system. Variation of particle size or additional coatings allow custom-design of workload release curves. An intrinsic cancer-sensitivity can be expected from the pH-dependent release in the acidic microenvironment of cancer tissue.

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Section: Particle Loadingsupporting

confidence: 52%

Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer

Svenskaya

Parakhonskiy

Haase

et al. 2013

Biophysical Chemistry

168

136

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“…However, PLGA microspheres prepared using the double emulsion technique frequently resulted in low encapsulation efficiency for water-soluble macromolecules, and loss of bioactivity [ 17 , 18 ]. For most of these methods, the harsh conditions such as shear or cavitation forces, excessive heat, freezing and drying involved in these encapsulation methods often cause significant inactivation of drugs like vaccine antigens [ 19 , 20 ]. For the emulsion electrospray method, electric field is added to the drug emulsion solution to spray particles.…”

Section: Introductionmentioning

confidence: 99%

Drug-nanoencapsulated PLGA microspheres prepared by emulsion electrospray with controlled release behavior

Yao

Liu

et al. 2016

Regen Biomater

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The development of modern therapeutics has raised the requirement for controlled drug delivery system which is able to efficiently encapsulate bioactive agents and achieve their release at a desired rate satisfying the need of the practical system. In this study, two kind of aqueous model drugs with different molecule weight, Congo red and albumin from bovine serum (BSA) were nano-encapsulated in poly (dl-lactic-co-glycolic acid) (PLGA) microspheres by emulsion electrospray. In the preparation process, the aqueous phase of drugs was added into the PLGA chloroform solution to form the emulsion solution. The emulsion was then electrosprayed to fabricate drug-nanoencapsulated PLGA microspheres. The morphology of the PLGA microspheres was affected by the volume ratio of aqueous drug phase and organic PLGA phase (Vw/Vo) and the molecule weight of model drugs. Confocal laser scanning microcopy showed the nanodroplets of drug phase were scattered in the PLGA microspheres homogenously with different distribution patterns related to Vw/Vo. With the increase of the volume ratio of aqueous drug phase, the number of nanodroplets increased forming continuous phase gradually that could accelerate drug release rate. Moreover, BSA showed a slower release rate from PLGA microspheres comparing to Congo red, which indicated the drug release rate could be affected by not only Vw/Vo but also the molecule weight of model drug. In brief, the PLGA microspheres prepared using emulsion electrospray provided an efficient and simple system to achieve controlled drug release at a desired rate satisfying the need of the practices.

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“…One to four repetitions resulted in efficiencies from 8 ± 2 μg/mg to (7 ± 2) · 10 −2 μg/mg. These efficiencies are of the same order as those of other substances loaded via adsorption to porous carriers [86][87][88]. Loading in pre-assembled capsules strongly depends on the type of cores used for the assembly of capsules.…”

Section: From Particles To Capsules: Dissolution Of Templatesmentioning

confidence: 75%

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Parakhonskiy

Yashchenok

Konrad

et al. 2014

Advances in Colloid and Interface Science

110

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Colloidal particles play an important role in various areas of material and pharmaceutical sciences, biotechnology, and biomedicine. In this overview we describe micro-and nano-particles used for the preparation of polyelectrolyte multilayer capsules and as drug delivery vehicles. An essential feature of polyelectrolyte multilayer capsule preparations is the ability to adsorb polymeric layers onto colloidal particles or templates followed by dissolution of these templates. The choice of the template is determined by various physico-chemical conditions: solvent needed for dissolution, porosity, aggregation tendency, as well as release of materials from capsules. Historically, the first templates were based on melamine formaldehyde, later evolving towards more elaborate materials such as silica and calcium carbonate. Their advantages and disadvantages are discussed here in comparison to non-particulate templates such as red blood cells. Further steps in this area include development of anisotropic particles, which themselves can serve as delivery carriers. We provide insights into application of particles as drug delivery carriers in comparison to microcapsules templated on them.

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Direct encapsulation of proteins into calcium silicate microparticles by water/oil/water interfacial reaction method and their responsive release behaviors

Cited by 16 publications

References 49 publications

Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer

Anticancer drug delivery system based on calcium carbonate particles loaded with a photosensitizer

Drug-nanoencapsulated PLGA microspheres prepared by emulsion electrospray with controlled release behavior

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

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