In this paper, the use of a tuned liquid column damper (TLCD) as a cost-effective means to control the seismic response of a base-isolated structure is studied. A straightforward direct approach for the optimal design of such a device is proposed, considering a white noise model of the base excitation. On this base, a direct optimization procedure of the TLCD design parameters is performed and optimal design charts are presented as a ready-to-use practical design tool. Comparison with the optimal parameters obtained considering a classical iterative statistical linearization technique proves the reliability of the proposed approach. The performance of the base-isolated TLCD-controlled structure is examined and compared with that of the simple base-isolated one (without TLCD), using a set of 44 recorded ground motions as base excitation. Theoretical and numerical results show that the TLCD is rather effective in reducing the response of base-isolated structures under strong earthquakes. Therefore, considering its advantageous characteristics and its overall beneficial effects, TLCDs can be considered as practical and appealing means to control the seismic response of base-isolated structures.