“…13 These data may explain, at least in part, the relatively higher concentrations of macrolides at the site of infection, in contrast to the lower serum levels. Furthermore, accumulation of macrolide was demonstrated not only in host cells but also in bacteria in a long incubation period, 14 a fi nding which may be associated with sub-MIC effects on pathogens and, perhaps, clinical effi cacy. These data suggests that macrolide antibiotics potentially exhibit antibacterial activity, not only through direct bactericidal and bacteriostatic effects but also by the suppression of bacterial virulence factors and the modulation of host defense systems.…”