Direct fractionation of spray-dried polymeric microparticles by inertial impaction

Beck-Broichsitter, Moritz; Strehlow, Boris; Kissel, Thomas

doi:10.1016/j.powtec.2015.08.033

Cited by 25 publications

(14 citation statements)

References 36 publications

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“…Generally, a higher solid concentration results in a lower feed rate (Beck-Broichsitter et al 2015b; Schmid 2011). A lower relative spray rate intensity reduces the feed rate almost linearly (Beck-Broichsitter et al 2015b). Figure 4B shows a linear correlation between the inlet and the outlet temperature for DCM solution in the Nano Spray Dryer B-90 (Büchi Labortechnik AG 2011).…”

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

“…C Feed rate as a function of the spray mesh size: (black bars) pure DCM (Büchi Labortechnik 2011) and (white bars) 5% (w/v) PLGA solution with sildenafil (10% of polymer mass) in acetone (Beck-Broichsitter et al 2015b) For pure DCM, the feed rates are in the ranges of 18, 32 and 107 g/h for a 4.0, 5.5, and 7.0 µm spray mesh, respectively (Büchi Labortechnik AG 2010). A significant increase in the flow rate from 18 to 128 g/h with a spray mesh size of 4.0 and 7.0 μm was also observed with a 5% (w/v) PLGA solution in acetone (Beck-Broichsitter et al 2015b). Figure 5 shows some SEM images of representative nano spray dried PLA/PLGA particles.…”

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

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PLA/PLGA nanoparticles prepared by nano spray drying

Arpagaus

2019

J. Pharm. Investig.

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Background Spray drying is a relatively simple, fast, reproducible and scalable drying technology that is suitable for drying heat-sensitive biopharmaceutical compounds. In view of the rapid progress of nanoencapsulation technologies in the pharmaceutical sector, nano spray drying is used in research to improve the powder formulation and release of active ingredients. The Nano Spray Dryer B-90 of the Swiss company Büchi Labortechnik AG extends the size of the powder particles produced into the nanometer scale with narrow size distributions and high encapsulation efficiency. Area covered This study explains the special nano spray drying technology and discusses the influence of the respective process parameters on the powder properties. Applications of nano spray drying for the formulation and encapsulation of active ingredients in PLA/PLGA biopolymers are investigated and discussed. Optimized process parameters for the application of nano spray drying of similar substances are presented. Expert opinion The analyzed studies show the possibility of producing PLGA particles from approx. 2 μm to below 200 nm by nano spray drying, as well as the encapsulation of various active ingredients in spherical particles and nano-in-nanoparticle composite structures made of PLGA polymers for controlled drug delivery systems. The researched applications are primarily in the therapeutic field, such as the treatment of inhalation diseases, inflammations, cancer, immune diseases, genetic disorders, the regulation of vasodilatation or the surface coating of medical implants with biocompatible PLGA nanoparticles.

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Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

PLA/PLGA nanoparticles prepared by nano spray drying

Arpagaus

2019

J. Pharm. Investig.

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“…Similarly, the outlet temperature increases with a smaller feed rate. 50,70 A drier powder is obtained at a higher inlet temperature. 71 Typical residual moisture contents of nano spraydried mannitol are below 0.5% and 2% to 5% for trehalose.…”

Section: Influence Of Process Parameters On Powder Propertiesmentioning

confidence: 99%

Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Bu ¨chi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly watersoluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

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“…O sistemade LEE et al, 2011) . Nesse momento, gotículas de tamanho uniforme são depositadas sobre a membrana, e o movimento vibracional promove a aspersão das gotículas pelo orifício da membrana para dentro da câmara de secagem (BROICHSITTER; STREHLOW;KISSEL, 2015). No sistema de aquecimento, uma espuma de metal porosa e compacta conduz o gás quente para dentro da câmara de secagem num fluxo laminar e numa taxa de aquecimento suave.…”

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“…Isso ocorre devido ao fato das micropartículas secas no pulverizador da série Nano, não passarem por um fracionamento, quanto ao seu tamanho, durante a etapa de recuperação no coletor eletrostático. Embora não ocorra esse fracionamento, esse pulverizador pode oferecer um índice de recuperação de partículas maior comparado a outros pulverizadores, uma vez que produtos farmacêuticos são caros e testados em baixa quantidade (BROICHSITTER; STREHLOW;KISSEL, 2015). Os pulverizadores da série Mini Spray Dryer possuem um sistema de coleta diferente, composto por um ciclone, o qual remove partículas menores, aumentando R50 b -40% c ) para 70% (Q95 a R50 b -70% c ) com relação à massa de quitosana.…”

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Preparação de micropartículas de quitosana incorporadas de nanogéis de poli-(N-vinilcaprolactama-<i>co</i>-ácido itacônico-<i>co</i>-dimetacrilato de etilenoglicol) via secagem por pulverização para liberação controlada de cetoprofeno

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Direct fractionation of spray-dried polymeric microparticles by inertial impaction

Cited by 25 publications

References 36 publications

PLA/PLGA nanoparticles prepared by nano spray drying

PLA/PLGA nanoparticles prepared by nano spray drying

Nano Spray-Dried Drugs for Oral Administration: A Review

Preparação de micropartículas de quitosana incorporadas de nanogéis de poli-(N-vinilcaprolactama-<i>co</i>-ácido itacônico-<i>co</i>-dimetacrilato de etilenoglicol) via secagem por pulverização para liberação controlada de cetoprofeno

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