Direct Growth of Human Enamel-Like Calcium Phosphate Microstructures on Human Tooth

Wang, Xiaokun; Xia, Chunjie; Zhang, Zhouhao; Deng, Xuliang; Wei, Shicheng; Zheng, Gang; Chen, Haifeng

doi:10.1166/jnn.2009.c157

Cited by 27 publications

(12 citation statements)

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“…Thus, according to the current knowledge, the enamel self-repairing ability by a passive remineralization appears to be doubtful, while an active remineralization is impossible. Nevertheless, investigations in this field keep going (Karlinsey and Mackey 2009;Karlinsey et al 2010a, b;Busch 2004;Onuma et al 2005;He and Feng 2007;Li et al 2008bLi et al , 2014aWang et al 2009;Roveri et al 2009a, b;Peters et al 2010;Orsini et al 2010;Uysal et al 2010;Niu et al 2014). For example, ACPcontaining orthodontic biocomposite resins might reduce the enamel decalcification found in patients with poor oral hygiene (Uysal et al 2010).…”

Section: Teethmentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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Section: Teethmentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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“…Investigators have attempted to precipitate an apatite coating on an enamel surface by electrolytic deposition ELD at 3–85 °C, but the crystals did not show an enamel-like structure (198). Others have demonstrated that phosphoric acid and fluoroapatite pastes can be used as feasible materials to form a hard repair layer on an enamel surface (198, 199). The layer was found to be organized as parallel fluoroapatite crystals without obvious structural gaps.…”

Section: Rebuilding Enamelmentioning

confidence: 99%

Protein-mediated Enamel Mineralization

2012

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Enamel is a hard nanocomposite bioceramic with significant resilience that protects the mammalian tooth from external physical and chemical damages. The remarkable mechanical properties of enamel are associated with its hierarchical structural organization and its thorough connection with underlying dentin. This dynamic mineralizing system offers scientists a wealth of information that allows the study of basic principals of organic matrix-mediated biomineralization and can potentially be utilized in the fields of material science and engineering for development and design of biomimetic materials. This chapter will provide a brief overview of enamel hierarchical structure and properties as well as the process and stages of amelogenesis. Particular emphasis is given to current knowledge of extracellular matrix protein and proteinases, and the structural chemistry of the matrix components and their putative functions. The chapter will conclude by discussing the potential of enamel for regrowth.

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“…In the past decades, enamel-mimicking material comprised of hydroxyapatite nanocrystal coatings have been synthesized using different in vitro methods. Biomimetic synthesis 1, 2 was a highly promising approach due to mild and biocompatible synthesis conditions in comparison to other approaches requiring harsh treatments such as a high temperature hydrothermal method3 and a method using a strong acid in a calcium phosphate paste 4, 5, 6…”

Section: Introductionmentioning

confidence: 99%

Amelogenin-assisted ex vivo remineralization of human enamel: Effects of supersaturation degree and fluoride concentration

et al. 2011

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The formation of organized nanocrystals that resemble enamel is crucial for successful enamel remineralization. Calcium, phosphate and fluoride ions and amelogenin are important ingredients for the formation of organized hydroxyapatite (HAP) crystals in vitro. However, the effects of these remineralization agents on the enamel crystal morphology have not been thoroughly studied. The objective of this study was to investigate the effects of fluoride ions, supersaturation degree and amelogenin on the crystal morphology and organization of ex vivo remineralized human enamel. Extracted third molars were sliced thin and acid-etched to provide the enamel surface for immersion in different remineralization solutions. The crystal morphology and mineral phase of the remineralized enamel surface were analyzed by FE-SEM, ATR-FTIR and XRD. The concentration of fluoride and supersaturation degree of hydroxyapatite had significant effects on the crystal morphology and crystal organization, which varied from plate-like loose crystals to rod-like densely packed nanocrystal arrays. Densely packed arrays of fluoridated hydroxyapatite nanorods were observed under the following conditions: σ(HAP) = 10.2±2.0 with fluoride 1.5±0.5 mg/L and amelogenin 40±10 µg/mL, pH 6.8±0.4. A phase diagram summarized the conditions that form dense or loose hydroxyapatite nanocrystal structures. This study provides the basis for the development of novel dental materials for caries management.

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Direct Growth of Human Enamel-Like Calcium Phosphate Microstructures on Human Tooth

Cited by 27 publications

References 0 publications

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Protein-mediated Enamel Mineralization

Amelogenin-assisted ex vivo remineralization of human enamel: Effects of supersaturation degree and fluoride concentration

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