Direct heterocyclization of benzocrown ethers

Abstract

ABSTRACT:The synthesis of novel 3,3-dialkyl-3,4-

The povarov reaction of cyclopentadiene with imines from methyl 12‐amino‐dehydroabietate

“…We continue our studies of heterocyclic compounds [12], and here we report the Povarov reaction of cyclopentadiene with imines 2a-c from methyl 12-aminodehydroabietate 1 and aromatic aldehydes (Scheme 1). The formation of condensed tetrahydroquinolines 3a-c is successfully catalyzed by CF 3 CO 2 H or BF 3 ·OEt 2 (Scheme 2).…”

Aliphatic aldehydes in the synthesis of carbo- and heterocycles: Part II. Synthesis of six- and seven-membered rings, bicyclic compounds, and macrocycles

“…The use of isobutyraldehyde instead of isobutylene oxide as twocarbon synthon in the Ritter reaction ensures easy preparation of 3,4-dihydroisoquinoline derivatives not only from dimethoxybenzenes but also from o-and p-xylenes. This makes the three-component synthesis from arene 64, nitrile 65, and isobutyraldehyde (1e) more attractive [73][74][75][76] (Scheme 17). The products were previously unknown dihydroisoquinolines 66.…”