Direct Human Contact with Siloxanes (Silicones) – Safety or Risk Part 1. Characteristics of Siloxanes (Silicones)

Mojsiewicz‐Pieńkowska, Krystyna; Jamrógiewicz, Marzena; Szymkowska, K.; Krenczkowska, Dominika

doi:10.3389/fphar.2016.00132

Cited by 116 publications

(82 citation statements)

References 36 publications

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“…It is not surprising since the degradation products of AS coating are mainly hydro-carbon (fat) and polysiloxane chains that both are biocompatible. 29 The fats can be quickly processed by the body, whereas silanes are widely used in biomedical applications and are biocompatible. 29,64 …”

Section: Discussionmentioning

confidence: 99%

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In vivo study of self‐assembled alkylsilane coated degradable magnesium devices

et al. 2018

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Magnesium (Mg) and its alloys are candidate materials for resorbable implantable devices, such as orthopedic devices or cardiovascular stents. Mg has a number advantages, including mechanical properties, light weight, its osteogenic effects and the fact that its degradation products are nontoxic and naturally present in the body. However, production of H gas during the corrosion reaction can cause formation of gas pockets at the implantation site, posing a barrier to clinical applications of Mg. It is therefore desirable to develop methods to control corrosion rate and gas pocket formation around the implants. Here we evaluate the potential of self-assembled multilayer alkylsilane (AS) coatings to control Mg device corrosion and formation of gas pockets in vivo and to assess effects of the AS coatings on the surrounding tissues in a subcutaneous mouse model over a 6 weeks' period. The coating significantly slowed down corrosion and gas pocket formation as evidenced by smaller gas pockets around the AS coated implants (ANOVA; p = 0.013) and decrease in the weight loss values (t test; p = 0.07). Importantly, the microCT and profilometry analyses demonstrated that the coating inhibited the pitting corrosion. Specifically, the roughness of the coated samples was ∼30% lower than uncoated specimen (p = 0.02). Histological assessment of the tissues under the implant revealed no inflammation or foreign body reaction. Overall, our results demonstrate the feasibility of use of the seld assembled AS coatings for reduction of gas pocket formation around the resorbable Mg devices. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

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Section: Discussionmentioning

confidence: 99%

“…29 The fats can be quickly processed by the body, whereas silanes are widely used in biomedical applications and are biocompatible. 29,64 …”

Section: Discussionmentioning

confidence: 99%

In vivo study of self‐assembled alkylsilane coated degradable magnesium devices

et al. 2018

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“…Up to a pyrolysis temperatures of 873 K, the disperse part of the surface energy is greater than the polar part because of the presence of www.advancedsciencenews.com www.aem-journal.com nonpolar organic groups (-C 2 H 5 and/or ÀCH 3 ) bonded to the inorganic ÀSi-O-chain that determine the hydrophobic character. This decrease in hydrophobicity and so increase in hydrophilicity can be seen in the increase of the polar part of the surface free energy, whereas the disperse part with the release of the nonpolar groups, the polar character of the Si-O bonds of the silicon backbone [30] dominates the surface properties.…”

Section: Contact Angle and Surface Structurementioning

confidence: 99%

Tailored Surface Properties of Ceramic Foams for Liquid Multiphase Reactions

et al. 2017

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Open cellular ceramic foams are prepared using the replica method. In a second step, these foams are coated with a pre-ceramic or polymer-derived ceramic coating, respectively. Polymer-to-ceramic transformation is studied by SEM with respect to the microstructure, functional groups are characterized by Raman microscopy, density and porosity are determined by pycnometer measurements as well as the surface free energy by means of contact angle measurements. By pyrolysis at different temperatures between 403 and 1273 K, the surface wettability is adjusted in a wide range from hydrophilic to hydrophobic due to the release of organic groups from the pre-ceramic polymers in terms of polymer-toceramic transformation. Coated foams are tested in a new potential application: as reactor internals to increase the liquid-liquid interface area in a homogeneously catalyzed multiphase system. As model reaction, a reactive extraction of an organic dye was used and the influence of the surface energy of the foam on the phase dispersion/reaction rate is discussed. The coated foams are able to increase the reaction rate to an extent depending on the surface wettability.

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“…Modern highly purified silicone products are available in the current practice which allow safer applications. Highly purified liquid silicone is chemically pure, free of particulate matter, clear, colorless, odorless, tasteless, nonvolatile, viscosity-constant within the range of human body temperatures [8] . Silicone fluids range in viscosity from 0.65 cSt (thinner than water) to more than 20,000,000 cSt (thicker than chewing gum) [9] .…”

Section: Introductionmentioning

confidence: 99%

Permanent volumizing and contouring of the lower face using 350 centistokes injectable silicone

Ulusal¹

2018

PAR

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cp -the higher the number, the more viscous the oil. Most of the reports used 1000-cp silicone oil for filling purposes and due to high viscosity, only microdroplet injection technique is recommended to avoid complications. This is the first report of patient series using liquid silicone with a 350-cp viscosity The objective of this study was to explore the reliability and efficacy of low viscosity liquid silicone for lower face contour correction.Methods: Lower facial region of 43 patients including chin, nasolabial and melolabial regions were treated by low viscosity (350 cp) liquid silicone. Instead of microdroplet tehniqe, retrograde linear threading technique was used. Total injection volume was 6.0 ± 3.9 mL. At least two sessions were required for complete correction which are spaced one month apart.Overcorrection was avoided. The treated areas had a soft and natural feeling with no lumpiness and stiffness.Results: Mean follow-up period was 16.8 ± 14.3 months. The mean aesthetic satisfaction score was 4.51. No migration of the material was seen which is revealed by palpation and no major complication was encountered. None of the patients had any complaints regarding late facial deformity due to silicone migration. Conclusion:Low viscosity liquid silicone is effective, well-tolerated and easy to use. It can be used as an alternative to higher viscosity silicones to avoid technical errors and complications.

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Direct Human Contact with Siloxanes (Silicones) – Safety or Risk Part 1. Characteristics of Siloxanes (Silicones)

Cited by 116 publications

References 36 publications

In vivo study of self‐assembled alkylsilane coated degradable magnesium devices

In vivo study of self‐assembled alkylsilane coated degradable magnesium devices

Tailored Surface Properties of Ceramic Foams for Liquid Multiphase Reactions

Permanent volumizing and contouring of the lower face using 350 centistokes injectable silicone

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