Direct identification and quantitative determination of costunolide and dehydrocostuslactone in the fixed oil ofLaurus novocanariensis by13C-NMR spectroscopy

Ferrari, Bernard; Castilho, Paula C.; Tomi, Félix; Rodrigues, Ana Isabel; Costa, María do Céu; Casanova, Joseph

doi:10.1002/pca.825

Cited by 27 publications

(24 citation statements)

References 11 publications

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“…These were isolated by column chromatography and identified by FTIR, MS, and NMR. The yields observed by isolation of these compounds were 3.4 and 1.7%, respectively, results that perfectly matched those obtained by quantitative 13 C NMR analysis of the whole oil (29).…”

supporting

confidence: 80%

Characterization of laurel fruit oil from Madeira Island, Portugal

Castilho

Costa

Rodrigues

et al. 2005

J Americ Oil Chem Soc

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The fixed oil extracted from Laurus spp. fruit from Madeira Island, Portugal, is used in local traditional medicine for a wide variety of health complaints. Physical properties, density and refractive index, as well as the TAG FA composition, sterols, and waxes were determined. The oil was found to have an unusually high content of volatiles (ca. 10%), with trans-ocimene and germacrene D predominating. Oleic (30%) and linoleic (20%) acids were the main unsaturated FA, whereas lauric (18%) and palmitic (up to 22.5%) acids were the main saturated FA in the neutral lipid fraction. The oil had a sterol content on the same order as olive oil, with β-sitosterol (84%) predominating. Two sesquiterpene lactones, dehydrocostuslactone and costunolide, accounted for 5% of the overall composition. Madeira laurel oil is not currently used as an edible oil because of its very strong flavor. Its claimed medicinal properties have not yet been validated, and this is the first report on the characterization of the commercial product.Paper no. J11122 in JAOCS 82, 863-868 (December 2005). FIG. 1.Bands a (trans-ocimene) and b (lactones) in the total oil (line 2) are absent in the spectrum of the lipidic fraction (line 1).

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supporting

confidence: 80%

Characterization of laurel fruit oil from Madeira Island, Portugal

Castilho

Costa

Rodrigues

et al. 2005

J Americ Oil Chem Soc

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“…Accumulated data indicate that Costunolide was isolated from many plant species such as Saussurea lappa Li et al, 2006;Zhang et al, 2011), Aucklandia lappa Decne (Li et al, 2005;Rasul et al, 2011), Michelia floribunda (Mondranondra et al, 1990), Magnolia grandiflora (el-Feraly and Chan, 1978;, Podachaenium eminens (Castro et al, 2000), Magnolia sieboldii (Park et al, 2001a;Park et al, 2001b), Tsoongiodendron odorum Chun (Song et al, 2001), Cosmos pringlei (Mata et al, 2002), Laurus nobilis (De Marino et al, 2005;Matsuda et al, 2002), Laurus novocanariensis (Ferrari et al, 2005), Magnolia kobus (Park et al, 2010), Eupatorium lindleyanum , and Magnolia ovata (Kassuya et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Costunolide: A novel anti-cancer sesquiterpene lactone

Rasul

Parveen

2012

Bangladesh J Pharmacol

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Costunolide: A novel anti Costunolide: A novel anti Costunolide: A novel anti---cancer cancer cancer sesquiterpene lactone sesquiterpene lactone sesquiterpene lactone BJP IntroductionCancer is the leading cause of death and represents one of the most threatening diseases worldwide. In the recent report, it has been estimated that 12.7 million new cancer cases and 7.6 million cancer deaths occur in 2008, with 56% of new cancer cases and 63% of the cancer deaths occurring in the less developed regions of the world (Ferlay et al., 2010). Throughout the history of civilization, the human have relied on natural products as a primary source of medicine. Herbal medicines have been proven to be an important source of novel agents with a pharmaceutical potential. Many anti-cancer drugs in current use are either natural products or are derived from natural products. Herbal medicines, such as paclitaxel, camptothecin, vinca alkaloids, and etoposide hold great potential as promising agents for the treatment of cancer (Cragg and Newman, 2005). Natural products have tradition-ally provided a rich source of drugs for many diseases, including cancer and plants are an important source of novel natural products (Amin et al., 2009). In 2008, of the 225 drugs being developed, 164 were of natural origin, with 108 being derived from plants, 25 from bacterial sources, 7 from fungal and 24 from animal sources. And, to throw some more numbers around, of the 108 plant-based drugs, 46 were in preclinical development, 14 in phase I, 41 in phase II, 5 in phase III and two had already reached pre-registration stage (Harvey, 2008). David Newman and Gordon Cragg (Newman and Cragg, 2007) found that of 155 FDA-approved small molecule anti-cancer drugs, 47% were either natural products or directly derived there from.C o s t u n o l i d e ( 6 E , 1 0 E , 1 1 a R ) -6 , 1 0 -d i m e t h y l -3 -methylidene-3a, 4,5,8,9,11a-hexahydrocyclodeca [b] furan-2-one) is a sesquiterpene lactone. It is a colorless crystalline powder with molecular formula of C15H20O2 and molecular weight of 232.318 g/mol (Figure 1). This review is aimed to summarize the recent researches on costunolide focusing on anti-cancer activity and to lay emphasis on molecular mechanisms which suggests a promising for such pursuits in oncology. Literature was searched through Pub Med, Scopus and Elsevier Science Direct Journal. Access to the Elsevier Science Direct Journal was made possible through library of AbstractCurrently an ample interest is found among oncologists to explore anti-cancer compounds from herbs. Sesquiterpene lactones have accredited significant attention in pharmacological research. Costunolide is a well-known sesquiterpene lactone present in plants used as popular herbal remedy. Several plantderived compounds are currently successfully employed in cancer treatment. Growing evidences demonstrated that costunolide possesses anti-cancer activities by inhibiting cell proliferation, tumor invasion, angiogenesis, metastasis and inducing apoptosis of a variety of tumor...

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“…L'huile contient aussi les lactones sesquiterpéniques costunolide et déhydrocostuslactone, en moyenne respectivement 3,8 et 1,5 % dans l'huile extraite à Madère [6,12].…”

Section: Constituants Chimiquesunclassified

Huile de graine/fruit de laurier Laurus nobilis L., Laurus azorica (Seub.) Franco, Laurus novocanariensis Rivas Mart., Lousã, Fern. Prieto, E. Dias, J.C. Costa et C. Aguiar

Ballabio

Goetz

2010

Phytothérapie

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Direct identification and quantitative determination of costunolide and dehydrocostuslactone in the fixed oil ofLaurus novocanariensis by13C-NMR spectroscopy

Cited by 27 publications

References 11 publications

Characterization of laurel fruit oil from Madeira Island, Portugal

Characterization of laurel fruit oil from Madeira Island, Portugal

Costunolide: A novel anti-cancer sesquiterpene lactone

Huile de graine/fruit de laurier Laurus nobilis L., Laurus azorica (Seub.) Franco, Laurus novocanariensis Rivas Mart., Lousã, Fern. Prieto, E. Dias, J.C. Costa et C. Aguiar

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