Direct impedimetric detection of exosomes and practical application in urine

Sazaklıoğlu, Sevda Akay; Torul, Hilal; Vatansever, Hafize Seda; Tamer, Uğur; Çelikkan, Hüseyin

doi:10.1007/s10800-022-01753-3

Cited by 4 publications

(2 citation statements)

References 43 publications

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“…The EC model consists of capacitances ( C ) and resistors ( R ) connected in series or parallel. When EC results fits equally well with ECL results, it gives significant analysis data for physicochemical features on the electrode surface . It has two EIS reading modes, non-Faradaic and Faradaic.…”

Section: Exosome Detection By Sensorsmentioning

confidence: 67%

“…When EC results fits equally well with ECL results, it gives significant analysis data for physicochemical features on the electrode surface. 220 It has two EIS reading modes, non-Faradaic and Faradaic. The most applied EC is the Randles circuit that consists of Warburg impedance (Z W ), double-layer capacitance (CDL), solution resistance (R S ), and charge transfer resistance (R CT ).…”

Section: ■ Exosome Detection By Sensorsmentioning

confidence: 99%

See 1 more Smart Citation

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Altıntaş,

Saylan

2023

Anal. Chem.

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Extracellular vesicles (EVs) are crucial mediators of intercellular communication and can be classified based on their physical properties, biomolecular structure, and origin. Among EVs, exosomes have garnered significant attention due to their potential as therapeutic and diagnostic tools. Exosomes are released via fusion of multivesicular bodies on plasma membranes and can be isolated from various biofluids using methods such as differential ultracentrifugation, immune affinity capture, ultrafiltration, and size exclusion chromatography. Herein, an overview of different techniques for exosome characterization and isolation, as well as the diverse applications of exosome detection, including their potential use in drug delivery and disease diagnosis, is provided. Additionally, we discuss the emerging field of exosome detection by sensors, which offers an up-and-coming avenue for point-of-care diagnostic tools development. Overall, this review aims to provide a exhaustive and up-to-date summary of the current state of exosome research.

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Section: Exosome Detection By Sensorsmentioning

confidence: 67%

Section: ■ Exosome Detection By Sensorsmentioning

confidence: 99%

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Altıntaş,

Saylan

2023

Anal. Chem.

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Sensitive and reliable lab-on-paper biosensor for label-free detection of exosomes by electrochemical impedance spectroscopy

Sazaklioglu,

Torul,

Tamer

et al. 2024

Microchim Acta

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Flexible electrochemical paper-based device for detection of breast cancer-derived exosome using nickel nanofoam 3D nanocomposite

Sahraei,

Mazloum-Ardakani,

Moradi

et al. 2024

J Appl Electrochem

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Exosomes as new biomarkers for cancer diagnosis have attracted attention because they are highly released by tumor cells in various biological uids. In this study, an electrochemical paper-based immunosensor device (Exo-sensing paper) is introduced for the detection of exosome in the serum. The Exo-sensing paper is a three electrode system that is prepared using pattern paper and carbon and silver inks. The sensor part of this immunosensor contains a three-dimensional porous nanocomposite of nickel nanofoam coupled with graphene oxide and gold nanoparticles. The high speci c surface area of this nanocomposite increases the antibody loading on the sensor surface signi cantly and consequently leads to obtaining a wide linear range of 500-1 × 10 7 Exospore/µL with a detection limit of 110 Exosome/µL. Due to some advantages of this constructed Exo-sensing paper such as easy storage, simple application, low cost and good selectivity in the real samples, this system has a good potential to be used as a point of care testing for in situ detection of the exosomes and is a promising strategy for minimally invasive liquid biopsy.

show abstract

Direct impedimetric detection of exosomes and practical application in urine

Cited by 4 publications

References 43 publications

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Exploring the Versatility of Exosomes: A Review on Isolation, Characterization, Detection Methods, and Diverse Applications

Sensitive and reliable lab-on-paper biosensor for label-free detection of exosomes by electrochemical impedance spectroscopy

Flexible electrochemical paper-based device for detection of breast cancer-derived exosome using nickel nanofoam 3D nanocomposite

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