Direct inhibition of rat detrusor muscle contraction by erythromycin

England, Roland C.D.; Norman, Robert I.; Elliott, Ruth A.

doi:10.1002/nau.20019

Cited by 7 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effect of tilmicosin phosphate on the intestinal motility of isolated rabbit duodenum revealed that tilmicosin phosphate inhibited the intestinal contractility in a dose dependent manner. These results were came in accordance with [52,53] who found to erythromycin macrolide antibiotic possess a concentration-dependent relaxant effects on the above intestinal parts but in different degree of intensity besides, erythromycin inhibits rat muscles contraction through the inhibition of calcium in lux and the modulation of intracellular calcium movement so depending on these data this might be also the same cause of the inhibitory effects of tilmicosin as reported by [54]. In the same way, [55] stated that azithromycin has a concentration-dependent, epithelium-independent, direct relaxant effect on muscles.…”

Section: Discussionsupporting

confidence: 90%

Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic)

Fia¹

2017

Insights Vet Sci

View full text Add to dashboard Cite

Tilmicosin (TMC) is a semi synthetic macrolide antibiotic of tylosin derivatives commonly used by veterinaries, has been shown to reveal benefi cial pharmacological activities. In the current study, the potential wound healing activity, Anti-oxidant effect (ulcer and hepatoprotective) were investigated. Anti-infl ammatory, antipyretic, analgesic (central and peripheral), hypnotic and antispasmodic activity were also screened. This study included adult both sexes of rats (200-250 gm), mice (20-25 gm) and adult rabbits. Experimental wound was induced on the anterior-dorsal side of each rat whereas, ulcer induced by ethanol causing mucosal damage in rats. The oral anti-infl ammatory induced through formalin producing edema, antipyretic (Brewer's yeast induced hyperthermia) and analgesic (writhing test, hot plate method, tail immersion method) while hypnotic effects induced through thiopental sodium. Anti-spasmodic effect on isolated organs (intestinal and uterine muscles) using new method of Modular Single Chamber Organ Bath were carried out on experimental animals. Tilmicosin antibiotic at different two doses of 20 and 40 mg/kg b.wt., has an important role in treatment of ulcer (cytoprotective effect) and improvement the wound healing processes besides anti-infl ammatory, analgesics, and anti-pyretic effects. Tilmicosin revealed also hypnotic and intestinal anti-spasmodic effects but showed Pharmacovigilence hepatotoxic effect through the histopathological studies which revealed sever hepatic damage especially at larger dose.How to cite this article: El-Ela FIA, El-Banna HA. Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic).

show abstract

Section: Discussionsupporting

confidence: 90%

Exploring novel medical applications for commonly used veterinary drug (tilmicosin antibiotic)

Fia¹

2017

Insights Vet Sci

View full text Add to dashboard Cite

show abstract

“…One report has associated recent use of nonsteroidal antiinflammatory drugs with onset of acute retention 86 . Other compounds, ranging from erythromycin 87 to St. John's Wort (Hypericum perforatum) , 88 inhibit detrusor contractility in vitro, yet the clinical relevance of muscle strip studies, particularly when high drug concentrations are studied, remains unclear. Case reports of urinary retention induced by potent psychoactive drugs (fluoxetine‐risperidone) 89 and sympathomimetic recreational drugs (“ecstasy”: methamphetamine) 90 also exist.…”

Section: Management Issuesmentioning

confidence: 99%

Detrusor Underactivity: Clinical Features and Pathogenesis of an Underdiagnosed Geriatric Condition

Taylor

Kuchel

2006

J American Geriatrics Society

191

137

View full text Add to dashboard Cite

Urinary incontinence and other lower urinary tract symptoms exert a major influence on the health and independence of frail older people. Detrusor underactivity (DU) is defined as a contraction of reduced strength and/or duration, resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span. DU may influence the clinical presentation and impede the therapy of disorders as common and as disparate as detrusor overactivity, urinary retention, and benign prostatic hyperplasia. Urodynamically, nearly two-thirds of incontinent nursing home residents exhibit DU. The clinical diagnosis of DU when present alone or in association with other bladder conditions such as detrusor overactivity (detrusor hyperactivity with impaired contractility (DHIC)) is challenging, because symptoms lack adequate precision. A catheterized and increasingly noninvasive ultrasound-based postvoid residual assessment allows a bedside diagnosis of retention and may suggest the presence of DU in individuals (mostly women) with a low likelihood of bladder outlet obstruction (BOO). Nevertheless, it cannot differentiate primary DU from retention secondary to BOO. The management of individuals with DHIC remains unsatisfactory, because antispasmodic anticholinergic medications may worsen retention, whereas bethanechol does not improve bladder emptying. Human detrusor biopsies reveal axonal degeneration, muscle loss, and fibrosis in DU. Animal studies suggest that multiple risk factors, including retention itself, lack of estrogen, infection, inflammation, and aging, may contribute to DU. Priority areas for future research include efforts to facilitate clinical nonurodynamic diagnosis of probable DU plus translational research designed to address the pathogenesis of this complex multifactorial geriatric syndrome.

show abstract