Direct Intercalation of Amino Acids into Layered Double Hydroxides by Coprecipitation

Aisawa, Sumio; Takahashi, Satoshi; Ogasawara, Wataru; Umetsu, Yoshio; Narita, Eiichi

doi:10.1006/jssc.2001.9340

Cited by 232 publications

(158 citation statements)

References 27 publications

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“…Recently, LDHs have attracted attention because such compounds intercalate bioactive molecules with negative charges into the interlayer to form bio-LDH nanohybrids [7][8][9][10]. The bio-nanohybrids are electrically neutral and can be transferred into biocells and organs through cell membranes.…”

Section: Introductionmentioning

confidence: 99%

Formation of hydrotalcite in aqueous solutions and intercalation of ATP by anion exchange

Tamura

Chiba

Ito

et al. 2006

Journal of Colloid and Interface Science

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The formation reaction and the intercalation of adenosine triphosphate (ATP) were studied for hydrotalcite (HT), a layered double hydroxide (LDH) of magnesium and aluminum. Hydrotalcite with nitrate ions in the interlayer (HT-NO 3 ) was formed (A) by dropwise addition of a solution of magnesium and aluminum nitrates (pH ca. 3) to a sodium hydroxide solution (pH ca. 14) until the pH decreased from 14 to 10 and (B) by dropwise addition of the NaOH solution to the solution of magnesium and aluminum nitrates with pH increasing from 3 to 10. The precipitate obtained with method (B) was contaminated with aluminum hydroxide and the crystallinity of the product was low, possibly because aluminum hydroxide precipitates at pH 4 or 5 and remains even after HT-NO 3 forms at pH above 8. With method (A), however, the precipitate was pure HT-NO 3 with increased crystallinity, since the solubility of aluminum hydroxide at pH above and around 10 is high as dissolved aluminate anions are stable in this high pH the triphosphate group, the adenosine group bends owing to its bond angles and projects into the interlayer to a height of 1 nm, and the adenosine groups aligned in the interlayer support the interlayer distance.

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Section: Introductionmentioning

confidence: 99%

Formation of hydrotalcite in aqueous solutions and intercalation of ATP by anion exchange

Tamura

Chiba

Ito

et al. 2006

Journal of Colloid and Interface Science

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“…As shown in Figure 4A, the pristine LDH-NO 3 spectrum contained some peaks that commonly appear in magnesium-aluminum layered double hydroxides spectra. 18,42 The broad absorption band around 3400 cm -1 was due to the stretching of O-H groups of both the hydroxide layer and interlayer water. The strong absorption band at 1384 cm -1 was due to stretching vibration of NO 3 -.…”

Section: Fourier Transform Infrared (Ftir) and Thermal Stability Analmentioning

confidence: 99%

“…Their low cost, good biocompatibility, low toxicity to mammalian cells, controlled-release system, and ability to provide full protection for loaded drugs make them suitable candidates for drug delivery systems. 11,12 Many LDH compounds intercalated with beneficial organic anions, such as deoxyribonucleic acid DNA, [13][14][15][16] amino acids, [17][18][19][20][21][22] anionic polymers, 23 pesticides, 24,25 and drugs, [26][27][28][29][30] have been prepared successfully. Special interests have focused on exploring the possibilities of using LDH drug delivery systems to deliver antiinflammatory drugs, 31 anticoagulants like heparin, 32 or anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids

Qin¹,

Wang²,

Zhu³

et al. 2013

IJN

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Magnesium-aluminum layered double hydroxides intercalated with antitumor drug etoposide (VP16) were prepared for the first time using a two-step procedure. The X-ray powder diffraction data suggested the intercalation of VP16 into layers with the increased basal spacing from 0.84-1.18 nm was successful. Then, it was characterized by X-ray powder diffraction, Fourier transform infrared spectroscopy, thermogravimetry and differential thermal analysis, and transmission electron microscopy. The prepared nanoparticles, VP16-LDH, showed an average diameter of 62.5 nm with a zeta potential of 20.5 mV. Evaluation of the buffering effect of VP16-LDH indicated that the nanohybrids were ideal for administration of the drugs that treat human stomach irritation. The loading amount of intercalated VP16 was 21.94% and possessed a profile of sustained release. The mechanism of VP16-LDH release in the phosphate buffered saline solution at pH 7.4 is likely controlled by the diffusion of VP16 anions from inside to the surface of LDH particles. The in vitro cytotoxicity and antitumor assays indicated that VP16-LDH hybrids were less toxic to GES-1 cells while exhibiting better antitumor efficacy on MKN45 and SGC-7901 cells. These results imply that VP16-LDH is a potential antitumor drug for a broad range of gastric cancer therapeutic applications.

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“…Since LDHs are anion-exchangers, various anions such as metal complex ions, 2),3) phosphate ions, 4) dodecyl sulfate ions, 5) various harmful oxyanions 6), 7) have been intercalated between their layers by ion-exchange. Various organic ions and molecules as well as inorganic ions can be intercalated into the layers using ion exchange and reconstruction methods such as alkylsulfate, 8) porphyrin, 9) phthalocyanine, 9) stearic acid, 10) oleic acid, 11)13) amino acids, 14) peptides, 15) DNAs 16) and so on. Since organic ions and molecules mentioned above are much larger than inorganic ions, such an intercalation is preferably performed generally by reconstruction than ion exchange method.…”

Section: Introductionmentioning

confidence: 99%

The effect of UV radiation on cinnamate/layered double hydroxide (LDH) composites

Kameshima

Nakada

Isobe

et al. 2013

J. Ceram. Soc. Japan

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Cinnamate/layered double hydroxide (LDH) composites were prepared by a reconstruction method using sodium cinnamate solution. The cinnamate solution of 100 mM was the most remarkable condition to obtain high cinnamate content of the cinnamate/LDH composite. The composite included about 30 mass % of cinnamate was prepared using the LDH with Mg/ Al = 2. In this composite, the new interlayer observed in XRD at 2ª = 4.5°formed a bilayer configuration of cinnamate. This composite showed excellent UV absorbability in UV-B region. Although the interlayer cinnamate changed into a dimer structure after UV radiation, the original UV absorbability was maintained in the composite.

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Direct Intercalation of Amino Acids into Layered Double Hydroxides by Coprecipitation

Cited by 232 publications

References 27 publications

Formation of hydrotalcite in aqueous solutions and intercalation of ATP by anion exchange

Formation of hydrotalcite in aqueous solutions and intercalation of ATP by anion exchange

The in vitro sustained release profile and antitumor effect of etoposide-layered double hydroxide nanohybrids

The effect of UV radiation on cinnamate/layered double hydroxide (LDH) composites

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