Direct Introduction of a Methyl Group at the C5‐Position of 1,2,4‐Triazines: Convenient Synthesis of 6‐Functionalized 5‐Aryl‐2,2′‐bipyridines

Abstract

This article describes a convenient method for the synthesis of 5‐aryl‐6‐methyl‐2,2′‐bipyridines through the direct introduction of a methyl group at the C5‐position of 1,2,4‐triazine moieties. At first 1,2,4‐triazine precursors are synthesized for this purpose. The reaction proceeds through SNH/SNips° substitution and subsequent aza‐Diels‐Alder reaction. In addition, mono‐ and dibromomethyl‐substituted 2,2’‐bipyridines are also synthesized to confirm the applicability of the present method.

Assessment on facile Diels–Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds

“…Further, our efforts have continued towards in the Diels–Alder reactions [ 10 – 12 ], cycloadditions [ 13 – 15 ], and adeptness in the structural studies of bioactive natural products [ 16 – 20 ]. Therefore, the present appraisal aims to emphasize the role of Diels–Alder approach of α-pyrones and terpenoquinone in the constructive cycles of natural complexes.…”