Direct introduction of phosphonate by the surface modification of polymers enhances biocompatibility

Choong, Cleo; Griffiths, Jon-Paul; Moloney, Mark G.; Triffitt, James T.; Swallow, D. L.

doi:10.1016/j.reactfunctpolym.2008.11.003

Cited by 29 publications

(17 citation statements)

References 52 publications

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“…Further, the immobilization of natural molecules by chemical modification and plasma surface treatments have also been studied [11]. However, the low stability of the modified polymers and the difficulty associated with their quantitative analysis remain unresolved [12].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of macroporous chitosan/poly(l-lactide) hybrid scaffolds by sodium acetate particulate-leaching method

Lim

Park

2011

J Porous Mater

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For tissue engineering applications, 3-D macroporous chitosan/poly(L-lactide) (PLLA) scaffolds were prepared by the particulate-leaching method using sodium acetate as the porogen in an acidic water/dioxane solution. The stability and dispersity of chitosan on the chitosan/ PLLA hybrid scaffolds were determined by measuring water contact angles, establishing crystallinity using X-ray diffraction, and using eosin staining to observe the chitosan under a light microscope. The porous structure of the particulate-leached chitosan/PLLA scaffolds was investigated in terms of pore morphology, interconnectivity, etc. by using scanning electron microscopy. Chitosan/PLLA scaffolds produced by particulate-leaching showed a highly porous structure and improved stability and dispersity of chitosan as compared to pure PLLA and chitosan-coated PLLA scaffolds. The highly porous structure that resulted from a high concentration of chitosan improved the efficiency of cell adhesion after culturing cells for 4 h. After 48 h, the cultured cells showed increased cell proliferation on the hybrid scaffolds. Thus, particulate-leached chitosan/ PLLA scaffolds can be applied to tissue engineering of various types, including the industrial membrane field.

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Section: Introductionmentioning

confidence: 99%

Fabrication of macroporous chitosan/poly(l-lactide) hybrid scaffolds by sodium acetate particulate-leaching method

Lim

Park

2011

J Porous Mater

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“…7 The method relies upon the generation of carbenes by thermolytic or photolytic methods and their irreversible attachment by insertion into available surface chemical groups; a similar approach has recently been reported by Hayes. [8][9][10] Significantly, this approach permits the possibility of a post-polymerisation step for control of surface properties, but without changing the bulk characteristics of the underlying substrate, and since the applicable substrates may be both organic and inorganic polymers and materials, it is potentially very wide in scope.…”

Section: Introductionmentioning

confidence: 99%

Chemical modification of materials by reaction with diaryl diazomethanes

Leonard

Moloney

Thompson

2009

Tetrahedron Letters

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“…In this work, a gelatin membrane, prepared by electrospinning in order to generate a porous structure, was surface modified with two bis(diaryldiazomethane)s. This modified gelatin membrane was a further example of the carbene modification of natural polymers, which had already been applied for the modification of color, hydrophobicity, biocompatibility, protein binding and adsorption, and payload delivery effects on various surfaces. The subsequent cross‐linking reaction between the end‐group amines and diisocyanates gave a structurally robust surface, which was expected to bind hydrogen peroxide and largely endowed with the antibacterial activity.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Post‐Modification, and Antibacterial Application of Gelatin Electrospun Membranes

Wang

Yang

et al. 2018

Macromolecular Bioscience

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Two bis(diaryldiazomethane)s substituted with amino groups are synthesized and used for the surface modification of membranes electrospun from gelatin. These membranes are then reacted with tolylene-2,4-diisocyanate to give urea-functionalized materials, so that hydrogen peroxide can be reversibly bound onto their surface. These membranes are characterized by scanning electron microscopy, XPS, differential scanning calorimeter, and tensile test to show their surface properties and bulk properties. The surface modification with amino-substituted diazomethanes and the subsequent cross-linking reaction with diisocyanates contribute to high loadings of hydrogen peroxide, and greatly increase the antibacterial activity of gelatin-derived membranes, which open a new horizon in the preparation of high loading antiseptic/antibacterial biomacromolecular surfaces and interfaces.

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Direct introduction of phosphonate by the surface modification of polymers enhances biocompatibility

Cited by 29 publications

References 52 publications

Fabrication of macroporous chitosan/poly(l-lactide) hybrid scaffolds by sodium acetate particulate-leaching method

Fabrication of macroporous chitosan/poly(l-lactide) hybrid scaffolds by sodium acetate particulate-leaching method

Chemical modification of materials by reaction with diaryl diazomethanes

Preparation, Post‐Modification, and Antibacterial Application of Gelatin Electrospun Membranes

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