Direct Mannich reaction mediated by Fe(Cp)2PF6 under solvent-free conditions

Three-component carbon-carbon bond-forming reactions for the synthesis of β-amino carbonyl compounds using maleic acid-catalyzed one-pot mannich-type reaction in ethanol

“…The structure of all known synthesized compounds according to this procedure were characterized by comparison of the melting points and the analytical data with those reported for authentic samples. The structure of the new synthesized β-amino ketones 4 is in full agreement with 1 H NMR, 13 C NMR and elemental analysis as illustrated below for a representative example (compound 4o). The IR spectrum of 4o displayed a sharp peak at 3380 cm -1 was due to NH and one sharp strong absorption band was observed at approximately 1665 cm -1 for C=O stretching.…”

“…The identity of the known products was confirmed by comparison of their spectroscopic data and physical properties with those available in published articles. The novel products were identified by spectral data (i.e., IR, 1 H-NMR, 13 C-NMR and CHN). The spectral data of the novel compounds as well as some representative compounds are described below.…”

“…The development of catalyst for synthetic methods has become an important research area, aiming to make the syntheses simpler, to save energy and to prevent toxicity in chemical processes. In recent years, the search for environmentally benign chemical processes or methodologies has received much attention (CHOUDHARY et al, 2006;KURESHY et al, 2010;. Therefore, in chemistry "ideal synthesis" has been defined as one in which the target compound is generated in one step, in efficiency yield, from readily available and inexpensive starting materials in a resource-effective and environmentally acceptable process (SANDAROOS and DAMAVANDI, 2013).…”

An Eco-Friendly Protocol for Synthesis of β- aminoketones via Mannich Reaction Using Citric Acid: A Biodegradable Catalyst

“…β-amino carbonyl derivatives are found in a number of biologically active natural products [5]. The reported Mannich reactions have been catalyzed by various Lewis or Brønsted acid catalysts such as silica-supported AlCl 3 [6], CeCl 3 .7H 2 0 [7], NbCl 5 [8], BiCl 3 [9], CAN [10], HClO 4 -SiO 2 [11], Bi(OTf) 3 [12], Zn(OTf) 2 [13], ionic liquid [14][15][16][17], sulphamic acid [18][19][20], Fe(Cp) 2 PF 6 [21], Cu-nanoparticles [22], [RE(PFO) 3 ] [23], silica based tin(II) catalyst [24], PEG-SO 3 H [25] ZSM-5-SO 3 H [26], carbon based solid acid [27], polyaniline/SiO 2 [28], lipase [29], saccharose [30], heteroplyacid salts [31]. However, most of the reported methods for the Mannich reaction suffer from drawbacks such as long reaction times and harsh reaction conditions, toxicity, and difficulty in product separation, which limit its use in the synthesis of complex molecules.…”

One Pot Synthesis of Multiaryl-Substitutedβ-Amino Ketone Compo- unds Catalyzed by Silica-Supported Rare Earth Terbium Chloride

“…Lewis 酸 [2～4] , Brønsted 酸 [5] , Ps-SO 3 H [6] , 氨基磺酸 [7] , 离 子液体酸 [8] 和杂多酸 [9] 等, 这类酸催化剂存在催化产率 低、催化反应时间长、催化反应步骤繁琐、污染环境和 对设备腐蚀等问题; 另一类是各种盐类或氧化物催化 剂, 像过渡金属盐 [10] , 稀土金属盐 [11] , 吡啶三氟醋酸 盐 [12] , Fe(Cp) 2 PF 6 [13] , NaBAr 4 F [14] , Yb(OTf) 3 [15] , Re-(PFO) 3 [16] , Re(OPf) 3 [17] , Nano TiO 2 [18] 等, 这类催化剂虽 然表现出很好的催化性能, 但存在分离困难、催化剂用 量大、催化产率低、污染环境以及催化剂难以回收利用 等问题. 近几年, 对支载、负载型催化剂研究越来越受重视, 文 献 报 道 , SiO 2 -OAlCl 2 [19] , H 2 SO 4 -SiO 2 [20] 和 HClO 4 -SiO 2 [21] 等已经作为一种新型催化剂应用到合成 β-氨基 …”