Direct Measurement of Reoxygenation in Malignant Mammary Tumors after a Single Large Dose of Irradiation

Vaupel, Peter; Frinak, Stanley; O'Hara, Michael D.

doi:10.1007/978-1-4684-4895-5_76

Cited by 30 publications

(13 citation statements)

References 17 publications

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“…Regarding hypoxic tumour cells, it is also known that ionizing radiation and some chemotherapeutic agents are less effective at low oxygen levels. Many studies on tumour oxygen tension levels using direct invasive measurements have been reported (Vaupel et al, 1984;Rampling et al, 1994;Brizel et al, 1996;Collingridge et al, 1997;Helmlinger et al, 1997;Al-Hallaq et al, 1998). Non-invasively, there has been increasing interest in measurements of changes in tissue oxygen tension using magnetic resonance imaging (MRI) methods.…”

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confidence: 99%

Preservation of tumour oxygen after hyperbaric oxygenation monitored by magnetic resonance imaging

Kinoshita¹,

Kohshi²,

Kunugita

et al. 2000

Br J Cancer

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Summary Hyperbaric oxygen (HBO) has been proposed to reduce tumour hypoxia by increasing the dissolved molecular oxygen in tissue. Using a non-invasive magnetic resonance imaging (MRI) technique, we monitored the changes in MRI signal intensity after HBO exposure because dissolved paramagnetic molecular oxygen itself shortens the T1 relation time. SCCVII tumour cells transplanted in mice were used. The molecular oxygen-enhanced MR images were acquired using an inversion recovery-preparation fast low angle shot (IR-FLASH) sequence sensitizing the paramagnetic effects of molecular oxygen using a 4.7 tesla MR system. MR signal of muscles decreased rapidly and returned to the control level within 40 min after decompression, whereas that of tumours decreased gradually and remained at a high level 60 min after HBO exposure. In contrast, the signal from the tumours in the normobaric oxygen group showed no significant change. Our data suggested that MR signal changes of tumours and muscles represent an alternation of extravascular oxygenation. The preserving tumour oxygen concentration after HBO exposure may be important regarding adjuvant therapy for cancer patients.

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confidence: 99%

Preservation of tumour oxygen after hyperbaric oxygenation monitored by magnetic resonance imaging

Kinoshita¹,

Kohshi²,

Kunugita

et al. 2000

Br J Cancer

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“…Quantitative measurements of pO 2 values can be performed using invasive probes that can provide instantaneous locoregional tumor oxygen tension in vivo. [5,6] Two types of pO 2 probes are frequently used to measure hypoxia: polarographic needle electrodes [5] and luminescence-based optical probes. [6] The microscopic distribution of hypoxia can be determined utilizing immunohistochemical staining with endogenous or exogenous hypoxia markers.…”

Section: Phenomena Of Tumor Hypoxiamentioning

confidence: 99%

Targeting Tumor Hypoxia in Radiotherapy: A Brief Review of Historical Background and Recent Progress

Zhang¹,

Zhou²,

Zhao³

et al. 2016

ERHM

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Tumor hypoxia is a physiologic barrier to radiotherapy and anti-tumor drug delivery. Numerous efforts have been made to overcome this barrier and to improve therapeutic outcomes. Strategies for targeting tumor hypoxia have included chemical radiosensitizers and hyperthermia, followed by combined synergic therapeutic modalities. Clinical hypoxia measurements and the development of molecular imaging agents prompted trials on dose escalation in external beam radiotherapy, which takes advantage of contemporary sophisticated radiation dose delivery techniques. Increases in our understanding of hypoxia-induced biological pathways have led to the investigation of various hypoxia targeting drugs. Radiolabeled hypoxia targeting drugs deliver radionuclides into hypoxic tumor cells and achieve highly localized cell death. In this manuscript, we briefly review the methods of targeting tumor hypoxia in radiotherapy. These include image guided dose escalation in external beam radiotherapy, radiosensitizers, and radiolabeled agents targeting hypoxia pathways and the receptors on hypoxic tumor cells. Our current understanding of tumor hypoxia is the culmination of the collective efforts of generations of researchers. New frontiers are continuing to expand, as new discoveries are being made on both the macroscopic and molecular levels.

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“…However, after a dose of 60 Gy a marked decrease in tumor oxygenation was obtained. Thus, reports on an improved microcirculation in tumors obtained during and shortly after the end of fractionated irradiation with noncurative doses [Reinhold, 1971;Kallman et al, 1972;Vaupel et al, 1985] must be assessed very critically with respect to our morphological and physiological results bearing in mind the differences in the tumor models used and the methods of detection applied.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural Studies on Tumor Capillaries of a Rat Rhabdomyosarcoma during Fractionated Radiotherapy

Zywietz

Hahn

Lierse³

1994

Cells Tissues Organs

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Sequential morphological changes in tumor capillaries of isotransplanted R1H rat rhabdomyosarcoma were observed weekly by transmission electron microscopy during fractionated radiotherapy (75 Gy/25 fractions/5 weeks). During the first 2 weeks of irradiation (up to 30 Gy), edema of the tumor capillary wall was induced. Swollen endothelial cells bulged into the vascular lumen and were surrounded by a widened subendothelial space with increased amounts of collagen fibrils (subendothelial edema). The endothelial lining was preserved up to the 3rd week of irradiation (45 Gy). Prolonged irradiation was associated with progressive destruction of the vascular wall including shrinkage, gradual loss of cell contacts, disappearance of the normal chromatin pattern, and increase of cytoplasmic vacuoles in endothelial cells as well as disruption of basal laminae. One week after the end of radiotherapy (75 Gy), the tumor capillaries showed complete necrosis. Progressive damage to tumor capillaries in the course of fractionated radiotherapy might have adverse effects on blood supply and thus on tumor oxygenation.

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Direct Measurement of Reoxygenation in Malignant Mammary Tumors after a Single Large Dose of Irradiation

Cited by 30 publications

References 17 publications

Preservation of tumour oxygen after hyperbaric oxygenation monitored by magnetic resonance imaging

Preservation of tumour oxygen after hyperbaric oxygenation monitored by magnetic resonance imaging

Targeting Tumor Hypoxia in Radiotherapy: A Brief Review of Historical Background and Recent Progress

Ultrastructural Studies on Tumor Capillaries of a Rat Rhabdomyosarcoma during Fractionated Radiotherapy

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