Direct medication delivery modifies the periodontal biofilm

Keller, Duane C; Buechel, Marissa

doi:10.7243/2053-5775-5-1

“…This use complies with the ADA and EPA recommendations. Prevention of infection may be enhanced by placing the Perio Tray™ with Perio Gel™ in the mouth and wearing a mask, but future studies are required [17][18][19]. The release of hydrogen peroxide is evident from this slide of a Perio Tray™ with Perio Gel™.…”

Section: Editorialmentioning

confidence: 99%

Untitled

2020

OJDOH

0

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The world is experiencing the ninth Severe Acute Respiratory Syndrome (SARS)-Coronavirus infection; the pandemic of 2020 cause by the SARS-CoV-2 (SARS-CoV-19) virus. The dental profession, the country and the world are unprepared for this event. This tragedy provides an opportunity to learn the steps that occur between cause and effects. A method is presented here for professional review that demonstrates a way patients may be helped in protecting themselves from these events through delivering and maintaining a 1/7% concentration of hydrogen peroxide (Perio Gel™) in the oral environment at the salivary duct openings using a custom formed FDA cleared medical device (Perio Tray™) [Perio Protect LLC, St Louis, Mo] DisclaimerThis editorial is a concept for professional review and use if warranted. There are no clinical studies to demonstrate efficacy of SARS-CoV-2 management with the Peril Protect Method™.

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“…This use complies with the ADA and EPA recommendations. Prevention of infection may be enhanced by placing the Perio Tray™ with Perio Gel™ in the mouth and wearing a mask, but future studies are required [17][18][19].…”

Section: Editorialmentioning

confidence: 99%

Perio Protect Method to Deliver Timed-Release Hydrogen Peroxide to the Salivary Ducts and the Oral Environment for Possible SARS-CoV-2 Protection

Keller

¹

2020

OJDOH

0

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The world is experiencing the ninth Severe Acute Respiratory Syndrome (SARS)-Coronavirus infection; the pandemic of 2020 cause by the SARS-CoV-2 (SARS-CoV-19) virus. The dental profession, the country and the world are unprepared for this event. This tragedy provides an opportunity to learn the steps that occur between cause and effects. A method is presented here for professional review that demonstrates a way patients may be helped in protecting themselves from these events through delivering and maintaining a 1/7% concentration of hydrogen peroxide (Perio Gel™) in the oral environment at the salivary duct openings using a custom formed FDA cleared medical device (Perio Tray™) [Perio Protect LLC, St Louis, Mo] DisclaimerThis editorial is a concept for professional review and use if warranted. There are no clinical studies to demonstrate efficacy of SARS-CoV-2 management with the Peril Protect Method™.

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“…The biofilm composition shifted from predominantly gram negative obligate anaerobes before to gram positive anaerobes, gram positive and negative facultative anaerobes and aerobic bacteria during treatment. There was a -log [2][3][4] reduction in the number of bacteria during treatment [28]. Fewer less virulent bacteria provided better treatment results through host responses to the improved subgingival conditions.…”

Section: Introductionmentioning

confidence: 99%

Chronic wound management of periodontal disease

Keller¹

2018

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Periodontal disease afflicts much of humankind, even when the patient seeks professional care and exercise homecare recommended by the dental profession. The accepted guidelines of the dental profession are scaling and root planing along with professional prophylaxis and sound home care. Patients suffer with periodontal disease even when they follow these guidelines. These guidelines are flawed because they are acute modality treatment guidelines, while periodontal disease is a chronic wound. The etiology and stages that occur in acute wounds differ significantly from chronic wounds. Acute wound treatment modalities are not capable of successfully treating most chronic wounds. The American Medical Association (AMA) has established guidelines for chronic wound management. The steps in theAMA guidelines of chronic wound therapy are incorporated into direct medication delivery in the treatment of chronic periodontal disease. The AMA guidelines recommend managing the etiology of disease using antimicrobials, oxygen and topical antiseptics before physical intervention. Once the cause is managed, wound debridement is an essential step along with long-term prevention of reoccurrence. Direct medication delivery has been shown to control the etiology of periodontal disease using a 1.7% hydrogen peroxide and a subclinical doxycycline dose to manage the biofilm. Long-term management and prevention of reoccurrence fulfill the guidelines of chronic wound management.

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Direct medication delivery modifies the periodontal biofilm

Cited by 4 publications

References 15 publications

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Perio Protect Method to Deliver Timed-Release Hydrogen Peroxide to the Salivary Ducts and the Oral Environment for Possible SARS-CoV-2 Protection

Chronic wound management of periodontal disease

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