2021
DOI: 10.1039/d1ob00122a
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Direct monitoring of biocatalytic deacetylation of amino acid substrates by 1H NMR reveals fine details of substrate specificity

Abstract: Amino acids are key synthetic building blocks that can be prepared in an entiopure form by biocatalytic methods. We show that the L-selective ornithine deacetylase ArgE catalyses hydrolysis of a...

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Cited by 2 publications
(4 citation statements)
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“…For the synthesis of compound 9 , Ala−OMe ⋅ HCl was initially converted into Ac−Ala−OMe by using AcCl in DCM. The obtained compound was then hydrolyzed at the ester functionality to 9 in basic conditions and used in the next steps [26] . Amine 6 was used as the starting point for the coupling reaction with different amino acids to obtain compounds 7 a – c , e – g , i , k , l – n .…”
Section: Resultsmentioning
confidence: 99%
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“…For the synthesis of compound 9 , Ala−OMe ⋅ HCl was initially converted into Ac−Ala−OMe by using AcCl in DCM. The obtained compound was then hydrolyzed at the ester functionality to 9 in basic conditions and used in the next steps [26] . Amine 6 was used as the starting point for the coupling reaction with different amino acids to obtain compounds 7 a – c , e – g , i , k , l – n .…”
Section: Resultsmentioning
confidence: 99%
“…Acetyl‐L‐alanine ( 8 ) . According with published procedure compound 8 was obtained as a colorless oil [26] …”
Section: Methodsmentioning
confidence: 99%
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