1997
DOI: 10.1016/s0278-6915(96)00067-1
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Direct mutagenicity of the polycylic aromatic hydrocarbon-containing fraction of smoked and charcoal-broiled foods treated with nitrite in acid solution

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Cited by 22 publications
(6 citation statements)
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“…Taken together, these data highlight the probable crucial role of monocytes in global pathogenesis of PAH toxicity. In addition, it is noteworthy that the lowest concentrations of BP active in vitro on monocytes, i.e., 0.5-1 M (125-250 ng/g), are close to those found in charcoal-broiled foods (up to 50 ng/g) (43) or in the mainstream smoke of a cigarette (20 -40 ng) (44) that, moreover, contain additional toxic PAHs (45). These data are consistent with the idea that humans may be exposed to PAH concentrations affecting monocytic cells.…”
Section: Discussionmentioning
confidence: 84%
“…Taken together, these data highlight the probable crucial role of monocytes in global pathogenesis of PAH toxicity. In addition, it is noteworthy that the lowest concentrations of BP active in vitro on monocytes, i.e., 0.5-1 M (125-250 ng/g), are close to those found in charcoal-broiled foods (up to 50 ng/g) (43) or in the mainstream smoke of a cigarette (20 -40 ng) (44) that, moreover, contain additional toxic PAHs (45). These data are consistent with the idea that humans may be exposed to PAH concentrations affecting monocytic cells.…”
Section: Discussionmentioning
confidence: 84%
“…Consequently, grilling smoked sausage could lead to a higher PAH intake than grilling non-smoked sausages. Additionally, the mutagenic activity of broiled meat and fish treated with nitrite is higher than that of broiled meat and fish without nitrite treatment 57 . Frying cured PM, especially bacon, increases the NOC concentration in food 29 .…”
Section: Table 2bmentioning
confidence: 89%
“…Lately, the direct mutagenic potential of 14 PAHs and PAHs containing fractions isolated from smoked and charcoal broiled samples, was studied towards strains TA 98 and TA 100 using the Ames test. The most potential mutagenicity was observed in PAHs fractions isolated from smoked fish, treated before smoking with nitrites in an acid solution [15]. To simplify an interpretation of real risk on human health, there have been attempts to express objectively the real risk using the toxic equivalency factor (TEF) [16 -19].…”
Section: Behavior Of Pahs In An Organismmentioning
confidence: 99%