Direct Myocardial Revascularization with Saphenous Vein Autograft

Favaloro, René G.; Effler, Donald B.; Groves, Laurence K.; Sheldon, William C.; Riahi, M.

doi:10.1378/chest.56.4.279

Cited by 43 publications

(19 citation statements)

References 2 publications

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“…In addition, our observation may also have important clinical implications for understanding pathological process of venous graft diseases. Autologous saphenous veins are widely used to circumvent occluded coronary arteries during coronary artery bypass grafting procedures in order to treat myocardial ischemic diseases [30]. Venous graft is susceptible to accelerated atherosclerosis and narrowing of the vessel lumen.…”

Section: Discussionmentioning

confidence: 99%

Hypertensive stretch regulates endothelial exocytosis of Weibel-Palade bodies through VEGF receptor 2 signaling pathways

Xiong

Han

et al. 2013

Cell Res

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Regulated endothelial exocytosis of Weibel-Palade bodies (WPBs), the first stage in leukocyte trafficking, plays a pivotal role in inflammation and injury. Acute mechanical stretch has been closely associated with vascular inflammation, although the precise mechanism is unknown. Here, we show that hypertensive stretch regulates the exocytosis of WPBs of endothelial cells (ECs) through VEGF receptor 2 (VEGFR2) signaling pathways. Stretch triggers a rapid release (within minutes) of von Willebrand factor and interleukin-8 from WPBs in cultured human ECs, promoting the interaction between leukocytes and ECs through the translocation of P-selectin to the cell membrane. We further show that hypertensive stretch significantly induces P-selectin translocation of intact ECs and enhances leukocyte adhesion both ex vivo and in vivo. Stretch-induced endothelial exocytosis is mediated via a VEGFR2/PLCγ1/calcium pathway. Interestingly, stretch also induces a negative feedback via a VEGFR2/Akt/nitric oxide pathway. Such dual effects are confirmed using pharmacological and genetic approaches in carotid artery segments, as well as in acute hypertensive mouse models. These studies reveal mechanical stretch as a potent agonist for endothelial exocytosis, which is modulated by VEGFR2 signaling. Thus, VEGFR2 signaling pathways may represent novel therapeutic targets in limiting hypertensive stretch-related inflammation.

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Section: Discussionmentioning

confidence: 99%

Hypertensive stretch regulates endothelial exocytosis of Weibel-Palade bodies through VEGF receptor 2 signaling pathways

Xiong

Han

et al. 2013

Cell Res

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“…Patients with myocardial infarction, acute myo-pericarditis, chronic rheumatic heart disease, or following cardiac surgery have augmented rates of AF. In fact, for the patients following coronary bypass grafting, the link has been noted since the report of the first 100 cases was published in 1969[31]; the initial incidence reported in that paper was 12% but has since been demonstrated to be 17-33% (and higher in valvular or hybrid procedures[32]. Multiple inflammatory markers have been linked with a propensity towards AF, including several of the interleukins (IL-2, IL-6, and IL-8), as well as C-reactive protein (CRP), tissue necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1)[33].…”

Section: Mechanismsmentioning

confidence: 99%

Atrial fibrillation

Thomas,

Li-Qun,

Win

2014

J Biomed Res

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Atrial fibrillation is the most common arrhythmia affecting patients today. Disease prevalence is increasing at an alarming rate worldwide, and is associated with often catastrophic and costly consequences, including heart failure, syncope, dementia, and stroke. Therapies including anticoagulants, anti-arrhythmic medications, devices, and non-pharmacologic procedures in the last 30 years have improved patients' functionality with the disease. Nonetheless, it remains imperative that further research into AF epidemiology, genetics, detection, and treatments continues to push forward rapidly as the worldwide population ages dramatically over the next 20 years.

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“…11 This procedure seems to be very promising; however, we should reserve our enthusiasm until further data and controlled studies are forthcoming and have been carefully analyzed.…”

Section: Preinfarction Anginamentioning

confidence: 99%

Treatment of Angina Pectoris

Gazes

1971

Postgraduate Medicine

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Direct Myocardial Revascularization with Saphenous Vein Autograft

Cited by 43 publications

References 2 publications

Hypertensive stretch regulates endothelial exocytosis of Weibel-Palade bodies through VEGF receptor 2 signaling pathways

Hypertensive stretch regulates endothelial exocytosis of Weibel-Palade bodies through VEGF receptor 2 signaling pathways

Atrial fibrillation

Treatment of Angina Pectoris

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