Large-eddy simulations of single-shock-driven mixing suggest that, for sufficiently high incident Mach numbers, a two-gas mixing layer ultimately evolves to a late-time, fully developed turbulent flow, with Kolmogorov-like inertial subrange following a −5/3 power law. After estimating the kinetic energy injected into the diffuse density layer during the initial shock-interface interaction, we propose a semi-empirical characterization of fully developed turbulence in such flows, based on scale separation, as a function of the initial parameter space, as, which corresponds to late-time Taylor-scale Reynolds numbers 250. In this expression, η 0 + represents the post-shock perturbation amplitude, u the change in interface velocity induced by the shock refraction, ν the characteristic kinematic viscosity of the mixture, L ρ the inner diffuse thickness of the initial density profile, A + the post-shock Atwood ratio, and C (A + , η 0 + /λ 0 ) ≈ 0.3 for the gas combination and post-shock perturbation amplitude considered. The initially perturbed interface separating air and SF 6 (pre-shock Atwood ratio A ≈ 0.67) was impacted in a heavy-light configuration by a shock wave of Mach number M I = 1.05, 1.25, 1.56, 3.0 or 5.0, for which η 0 + is fixed at about 25 % of the dominant wavelength λ 0 of an initial, Gaussian perturbation spectrum. Only partial isotropization of the flow (in the sense of turbulent kinetic energy and dissipation) is observed during the late-time evolution of the mixing zone. For all Mach numbers considered, the late-time flow resembles homogeneous decaying turbulence of Batchelor type, with a turbulent kinetic energy decay exponent n ≈ 1.4 and large-scale (k → 0) energy spectrum ∼ k 4 , and a molecular mixing fraction parameter, Θ ≈ 0.85. An appropriate time scale characterizing the Taylor-scale Reynolds number decay, as well as the evolution of mixing parameters such as Θ and the effective Atwood ratio A e , seem to indicate the existence of low-and high-Mach-number regimes.