Direct, one-step molding of 3D-printed structures for convenient fabrication of truly 3D PDMS microfluidic chips

Chan, Ho Nam; Chen, Yangfan; Shu, Yiwei; Chen, Yin; Tian, Qian; Wu, Hongkai

doi:10.1007/s10404-014-1542-4

Cited by 205 publications

(164 citation statements)

References 42 publications

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“…The approach we have used here can be used to evaluate other enhanced oil recovery systems, including other types of polymers or surfactants [80], nanoparticles [81,82], and foams [83,84]. Our platform can also be applied to other porous media situations that involve diffusion and transport in biomedical systems [40,85], carbon sequestration [86,87], and the additive manufacturing of complex fluid networks [41,88,89]. …”

Section: Discussionmentioning

confidence: 99%

Waterflooding of Surfactant and Polymer Solutions in a Porous Media Micromodel

Yeh

Juárez

2018

Colloids and Interfaces

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Abstract:In this study, we examine microscale waterflooding in a randomly close-packed porous medium. Three different porosities were prepared in a microfluidic platform and saturated with silicone oil. Optical video fluorescence microscopy was used to track the water front as it flowed through the porous packed bed. The degree of water saturation was compared to water containing two different types of chemical modifiers, sodium dodecyl sulfate (SDS) and polyvinylpyrrolidone (PVP), with water in the absence of a surfactant used as a control. Image analysis of our video data yielded saturation curves and calculated fractal dimension, which we used to identify how morphology changed the way in which an invading water phase moved through the porous media. An inverse analysis based on the implicit pressure explicit saturation (IMPES) simulation technique used mobility ratio as an adjustable parameter to fit our experimental saturation curves. The results from our inverse analysis combined with our image analysis show that this platform can be used to evaluate the effectiveness of surfactants or polymers as additives for enhancing the transport of water through an oil-saturated porous medium.

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Section: Discussionmentioning

confidence: 99%

Waterflooding of Surfactant and Polymer Solutions in a Porous Media Micromodel

Yeh

Juárez

2018

Colloids and Interfaces

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“…With 3D-printed double-sided molding, however, fluidic vias are far simpler to fabricate 45,46 . Using double-sided molding techniques with columns that run from the bottom mold and fit into the upper mold (Figure 3b), smaller mold-mold alignment marks can be constructed that allow fluid to flow between the top and bottom face of a single layer of PDMS (Figure 1a) or between layers of bonded PDMS (Figure 5b), thus enabling multilayer microfluidic devices.…”

Section: Multisided and Multilayer Molding Techniquesmentioning

confidence: 99%

“…Although similar to fugitive ink processes [43][44][45] , fugitive ink molding has fewer geometric constraints but requires a printing step for every final device, whereas solid internal structures must be designed for withdrawal but can be reused 23,41,42 . Chan et al 46 have fabricated molds with overhangs in a basket weave pattern, which can be used to generate microfluidic vias and valving in a single step, repairing demolding damage by thermally healing the PDMS, with the restriction that the vias be designed in parallel.…”

Section: Introductionmentioning

confidence: 99%

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

et al. 2016

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A critical feature of state-of-the-art microfluidic technologies is the ability to fabricate multilayer structures without relying on the expensive equipment and facilities required by soft lithography-defined processes. Here, three-dimensional (3D) printed polymer molds are used to construct multilayer poly(dimethylsiloxane) (PDMS) devices by employing unique molding, bonding, alignment, and rapid assembly processes. Specifically, a novel single-layer, two-sided molding method is developed to realize two channel levels, non-planar membranes/valves, vertical interconnects (vias) between channel levels, and integrated inlet/outlet ports for fast linkages to external fluidic systems. As a demonstration, a single-layer membrane microvalve is constructed and tested by applying various gate pressures under parametric variation of source pressure, illustrating a high degree of flow rate control. In addition, multilayer structures are fabricated through an intralayer bonding procedure that uses custom 3D-printed stamps to selectively apply uncured liquid PDMS adhesive only to bonding interfaces without clogging fluidic channels. Using integrated alignment marks to accurately position both stamps and individual layers, this technique is demonstrated by rapidly assembling a six-layer microfluidic device. By combining the versatility of 3D printing while retaining the favorable mechanical and biological properties of PDMS, this work can potentially open up a new class of manufacturing techniques for multilayer microfluidic systems.

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“…Microfluidic channels were cast from PDMS (1:10 base to cross-linker), which was degassed at a pressure of 5 mBar for 20 min. Prior to casting PDMS over the mold, the resin surface was passivated by depositing a fluorocarbon film in a reactive-ion etcher [27][28][29] (low pressure CHF 3 for 120 s at an RF power of 45 W). PDMS was next cast onto the passivated molds and baked at 70 C for 1 h. The cured material was then peeled from the mold and sonicated for 20 min in acetone to dissolve the embedded ABS tube and thereby produce a fully 3D fluidic channel of dimensions w ¼ 500 lm, t ¼ 100 lm, and h ¼ 1:3 mm [ Fig.…”

Section: -6951/2017/111(23)/234102/5mentioning

confidence: 99%

A planar surface acoustic wave micropump for closed-loop microfluidics

Rimsa

Smith

Wälti

et al. 2017

Applied Physics Letters

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We have designed and characterized a simple Rayleigh-surface acoustic wave-based micropump, integrated directly with a fully enclosed 3D microfluidic system, which improves significantly the pumping efficiency within a coupled fluid whilst maintaining planar integration of the micropump and microfluidics. We achieve this by exploiting the Rayleigh-scattering angle of surface acoustic waves into pressure waves on contact with overlaid fluids, by designing a microfluidic channel aligned almost co-linearly with the launched pressure waves and by minimizing energy losses by reflections from, or absorption within, the channel walls. This allows the microfluidic system to remain fully enclosed—a pre-requisite for point-of-care applications—removing sources of possible contamination, whilst achieving pump efficiencies up to several orders of magnitude higher than previously reported, at low operating powers of 0.5 W.

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Direct, one-step molding of 3D-printed structures for convenient fabrication of truly 3D PDMS microfluidic chips

Cited by 205 publications

References 42 publications

Waterflooding of Surfactant and Polymer Solutions in a Porous Media Micromodel

Waterflooding of Surfactant and Polymer Solutions in a Porous Media Micromodel

Rapid assembly of multilayer microfluidic structures via 3D-printed transfer molding and bonding

A planar surface acoustic wave micropump for closed-loop microfluidics

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