Direct Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation and Low Body Weight

Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation

“…More recently, an analysis of the Korean National Health Insurance Service database found that patients with AF and low body weight (<50 kg) receiving OAC had a higher incidence of ischemic stroke than those weighting 50 to 60 kg. 24 The present study is consistent with these results, as a low BMI was a significant risk factor associated with ischemic stroke. It should be pointed out, however, that 57 patients with the single risk factor of low BMI had no ischemic stroke event during follow-up.…”

Dose Selection of Non-Vitamin K Antagonist Oral Anticoagulants in Korean Patients with Non-Valvular Atrial Fibrillation

“…20) In the Asian population, reduced doses of NOACs were mainly prescribed to patients with AF, and the use of such doses was considerably more common in the Asian population than in the non-Asian population ( Table 2). [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] There are several potential reasons for the more frequent use of reduced dose NOACs in Asian patients with AF. First, Asians generally have a lower body weight and smaller body size than non-Asians, who were represented to a greater degree in the pivotal RCTs.…”

“…First, Asians generally have a lower body weight and smaller body size than non-Asians, who were represented to a greater degree in the pivotal RCTs. 28) Second, Asians were shown to have a higher risk of ICH than non-Asians in the warfarin era. 39) Physicians may tend to be more conservative than aggressive in an attempt to avoid adverse bleeding events when they prescribe OAC therapy for patients with AF.…”

Effectiveness and Safety of Direct Oral Anticoagulant for Secondary Prevention in Asians with Atrial Fibrillation

“…Patient demographics, comorbidities, and details of concomitant medications were retrieved from the database. Table S1 summarizes the detailed definitions (based on ICD-10-CM codes) of comorbidities, including hypertension, diabetes mellitus, dyslipidemia, congestive heart failure, prior myocardial infarction, peripheral artery disease, renal disease, chronic obstructive pulmonary disease, cancer, and a history of intracranial hemorrhage (ICH) and gastrointestinal bleeding (GIB) [13][14][15]. The CHA 2 DS 2 -VASc score to evaluate stroke risk, the HAS-BLED score (Hypertension (1 point), liver disease (1 point), renal disease (1 point), stroke history (1 point), bleeding history (1 point), age >65 years (1 point) and drug (concomitant use of NSAID or antiplatelet agent, 1 point)) to assess bleeding risk (Table S1), and the Charlson comorbidity index (CCI) that quantifies a patient's comorbidity burden was calculated by combining covariates [16][17][18].…”