Direct perfusion measurements of cancellous bone anisotropic permeability

Kohles, Sean S.; Roberts, Julie B.; Upton, Maureen L.; Wilson, Christopher G.; Bonassar, Lawrence J.; Schlichting, Alyssa L.

doi:10.1016/s0021-9290(01)00082-3

Cited by 113 publications

(80 citation statements)

References 22 publications

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“…1b, and exhibit a large variability that coincides with studies reporting experimental measurements of the permeability κ 0 (1 × 10 −12 -1 × 10 −7 m 2 ) on cancellous bone [2,3,22,[27][28][29][30][31]. The variability of the intrinsic permeability in porous media is due to the dependence of the permeability on the porosity [22,31] and the microstructure of the sample [2,27,28,31].…”

Section: Dynamic Permeability and Dissipation Phenomena Due To Viscousupporting

confidence: 78%

Difficulties arising from different definitions of tortuosity for wave propagation in saturated poroelastic media models

Cowin

Cardoso

2013

Z Angew Math Mech

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The multiple definitions of permeability and tortuosity employed by investigators modifying the basic equations of dynamic poroelasticity pose a problem as some resulting analyses produce results conflicting with those of other investigators. When the same words are used to describe different definitions of different concepts, the problem is compounded. These problems were highlighted in recent applications of acceleration wave analyses of dynamic poroelasticity. Wilmanski [40] and Coussy [14] applied acceleration wave analysis to their own systems of dynamic poroelastic equations and found contradictory results. In one case the wave speed depends upon tortuosity and in the other case a dependence upon permeability (and tortuosity) was not allowed. This means that acceleration waves in the Wilmanski [40] analysis cannot exhibit dispersion at lower frequencies. Harmonic wave analyses applied to the same systems of dynamic poroelastic equations predict a dependence of wave speed upon permeability. The acceleration wave analysis of a system of dynamic poroelastic equations is dependent upon the definitions of tortuosity used by the investigators. Wilmanski [40] and Coussy [14] each used their own definition of tortuosity.

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Section: Dynamic Permeability and Dissipation Phenomena Due To Viscousupporting

confidence: 78%

Difficulties arising from different definitions of tortuosity for wave propagation in saturated poroelastic media models

Cowin

Cardoso

2013

Z Angew Math Mech

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“…46 An electronic caliper was used to measure the length and diameter of the specimens. The cylindrical bone samples were ultrasonically cleaned (Cest ultrasonic, model P1100SR, USA) 46 with a chemical detergent (Pumicized, Gent-l-kleen, USA) 32 for marrow removal. Excessive marrow was further cleansed with water and air jets.…”

Section: Sample Preparation and µCt Imagingmentioning

confidence: 99%

Uniaxial and Multiaxial Fatigue Life Prediction of the Trabecular Bone Based on Physiological Loading: A Comparative Study

et al. 2015

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Abstract-Fatigue assessment of the trabecular bone has been developed to give a better understanding of bone properties. While most fatigue studies are relying on uniaxial compressive load as the method of assessment, in various cases details are missing, or the uniaxial results are not very realistic. In this paper, the effect of three different load histories from physiological loading applied on the trabecular bone were studied in order to predict the first failure surface and the fatigue lifetime. The fatigue behaviour of the trabecular bone under uniaxial load was compared to that of multiaxial load using a finite element simulation. The plastic strain was found localized at the trabecular structure under multiaxial load. On average, applying multiaxial loads reduced more than five times the fatigue life of the trabecular bone. The results provide evidence that multiaxial loading is dominated in the low cycle fatigue in contrast to the uniaxial one. Both bone volume fraction and structural model index were best predictors of failure (p < 0.05) in fatigue for both types of loading, whilst uniaxial loading has indicated better values in most cases.

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“…Also the marrow will effect to increasing modulus, strength, and energy absorption of the specimen [41]. The cylindrical bone samples were then cleaned using an ultrasonic cleaner (Cest ultrasonic, model P1100SR, USA) [4,42] with a chemical detergent (Pumicized, Gent-l-kleen, USA) [43]. Water jets and air jets were used to remove any excess of water and bone marrow from the bone samples.…”

Section: Specimen Preparationmentioning

confidence: 99%

Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation

Syahrom

Kadir

Abdullah

et al. 2011

Med Biol Eng Comput

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The relationship between microarchitecture to the failure mechanism and mechanical properties can be assessed through experimental and computational methods. In this study, both methods were utilised using bovine cadavers. Twenty four samples of cancellous bone were extracted from fresh bovine and the samples were cleaned from excessive marrow. Uniaxial compression testing was performed with displacement control. After mechanical testing, each specimen was ashed in a furnace. Four of the samples were exemplarily scanned using micro-computed tomography (μCT) and three dimensional models of the cancellous bones were reconstructed for finite element simulation. The mechanical properties and the failure modes obtained from numerical simulations were then compared to the experiments. Correlations between microarchitectural parameters to the mechanical properties and failure modes were then made. The Young's modulus correlates well with the bone volume fraction with R² = 0.615 and P value 0.013. Three different types of failure modes of cancellous bone were observed: oblique fracture (21.7%), perpendicular global fracture (47.8%), and scattered localised fracture (30.4%). However, no correlations were found between the failure modes to the morphological parameters. The percentage of error between computer predictions and the actual experimental test was from 6 to 12%. These mechanical properties and information on failure modes can be used for the development of synthetic cancellous bone.

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Direct perfusion measurements of cancellous bone anisotropic permeability

Cited by 113 publications

References 22 publications

Difficulties arising from different definitions of tortuosity for wave propagation in saturated poroelastic media models

Difficulties arising from different definitions of tortuosity for wave propagation in saturated poroelastic media models

Uniaxial and Multiaxial Fatigue Life Prediction of the Trabecular Bone Based on Physiological Loading: A Comparative Study

Mechanical and microarchitectural analyses of cancellous bone through experiment and computer simulation

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