Direct Pulp Capping with Advanced Platelet-Rich Fibrin: A Report of Two Cases

Abstract

This article aims to prove dentin bridge formation in two cases after direct pulp capping in reversible pulpitis using the platelet concentrate A-PRF+ and preservation of the vitality of the dental pulp. The hemostasis process for the pulp wound and cavity disinfection with gaseous ozone was performed under anesthesia. A large A-PRF+ membrane was prepared from blood plasma and applied to the pulp wound. After placing an MTA, the cavity was closed using glass-ionomer cement. Clinical and cone beam computed tomography findings demonstrated the formation of a dentin bridge in both cases. After the definitive restoration was conducted during the sixth month, the teeth from both patients were asymptomatic and had normal electric pulp testing values. Conclusions: Via clinical and CBCT examinations, we observed the dentin bridge formation after placing the platelet concentrate A-PRF+ in both cases. The vitality of the dental pulp was preserved. Further research is needed to refine the clinical protocol, recommended period for control examination, clarification of the precise indications of platelet concentrates, etc.

Radiographic Outcomes of Mineral Trioxide Aggregate (MTA) with and Without Platelet-Rich Fibrin (PRF) In Direct Pulp Capping: A Clinical Pilot Study

“…16 Though it has used extensively in pulpotomy and has shown successful results, its efficacy as a DPC agent is a comparatively recent area of research. 17,18 The present clinic-radiographic study aims to study the effect of combined use of MTA and PRF, as compared with MTA alone, as depicted by an increase in radiographic density beneath the point of pulpal exposure the null hypothesis stated was that there would be no increase is radiographic density when using PRF in combination with MTA compared to MTA alone. To the best of the authors' information, no clinical trial comparing outcomes of PRF in combination with MTA for direct pulp capping has yet been published.…”

“…16 Though it has used extensively in pulpotomy and has shown successful results, its efficacy as a DPC agent is a comparatively recent area of research. 17,18…”