Direct radioimmunoassay of angiotensin-converting enzyme in sera from patients with pulmonary diseases

Hiwada, Kunio; Inoue, Yoshikazu; Takada, Yasuharu; Hashimoto, Akihide; Akutsu, Hiroshi; Kitatani, Fumihiko; Kokubu, Tatsuo

doi:10.1007/bf02714418

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…The values for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and DLco were related to % predicted values [ 12 ]. Serum angiotensin converting enzyme (ACE) (normal range, 8.3–21.4 U/L) was measured by modified colorimetric assay using Kasahara's method [ 13 ]. Serum Krebs von den Lungen-6 (KL-6) (normal range <500 U/L) and surfactant protein-D (SP-D) (normal range, <110 ng/mL) were measured by the enzyme-linked immunosorbent assay using commercially available kits (ED046; Eizai Co. Ltd., Tokyo, Japan, and SP-D ELISA; Yamasa Co., Tokyo, Japan; respectively) [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Poor Outcome and Mortality in Patients with Lower Lung-Dominant Sarcoidosis

Tachibana

Akira

Arai

et al. 2023

Canadian Respiratory Journal

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Background. Pulmonary sarcoidosis predominantly affects the upper lung zones but sometimes affects the lower lung zones. We hypothesised that patients with lower lung zone-dominant sarcoidosis had lower baseline forced vital capacity, progressive restrictive lung function decline, and higher long-term mortality. Methods. We retrospectively reviewed clinical data including the pulmonary function tests of 108 consecutive patients with pulmonary sarcoidosis pathologically confirmed by lung and/or mediastinal lymph node biopsy from 2004 to 2014 from our database. Results. Eleven patients (10.2%) with lower lung zone-dominant sarcoidosis were compared with 97 patients with nonlower lung zone-dominant sarcoidosis. The median age of the patients with lower dominance was significantly older (71 vs. 56, p = 0.0005 ). The patient with lower dominance had a significantly lower baseline percent forced vital capacity (FVC) (96.0% vs. 103%, p = 0.022 ). The annual change in FVC was −112 mL in those with lower dominance vs. 0 mL in nonlower dominance ( p = 0.0033 ). Fatal acute deterioration was observed in three patients (27%) in the lower dominant group. Overall survival in the lower dominant group was significantly worse. Conclusions. Patients with lower lung zone-dominant sarcoidosis had an older age and lower baseline FVC with disease progression and acute deterioration associated with higher long-term mortality.

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Section: Methodsmentioning

confidence: 99%

Poor Outcome and Mortality in Patients with Lower Lung-Dominant Sarcoidosis

Tachibana

Akira

Arai

et al. 2023

Canadian Respiratory Journal

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Focus on increased serum angiotensin-converting enzyme level: From granulomatous diseases to genetic mutations

Lopez‐Sublet

Lanzacco

Danser

et al. 2018

Clinical Biochemistry

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Mechanistically Identified Suitable Biomarkers of Exposure, Effect, and Susceptibility for Silicosis and Coal-Worker'S Pneumoconiosis: A Comprehensive Review

Gulumian

Borm

Vallyathan

et al. 2006

Journal of Toxicology and Environmental Health, Part B

114

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Clinical detection of silicosis is currently dependent on radiological and lung function abnormalities, both late manifestations of disease. Markers of prediction and early detection of pneumoconiosis are imperative for the implementation of timely intervention strategies. Understanding the underlying mechanisms of the etiology of coal workers pneumoconiosis (CWP) and silicosis was essential in proposing numerous biomarkers that have been evaluated to assess effects following exposure to crystalline silica and/or coal mine dust. Human validation studies have substantiated some of these proposed biomarkers and argued in favor of their use as biomarkers for crystalline silica- and CWP-induced pneumoconiosis. A number of "ideal" biological markers of effect were identified, namely, Clara cell protein-16 (CC16) (serum), tumor necrosis factor-alpha (TNF-alpha) (monocyte release), interleukin-8 (IL-8) (monocyte release), reactive oxygen species (ROS) measurement by chemiluminescence (neutrophil release), 8-isoprostanes (serum), total antioxidant levels measured by total equivalent antioxidant capacity (TEAC), glutathione, glutathione peroxidase activity, glutathione S-transferase activity, and platelet-derived growth factor (PDGF) (serum). TNF-alpha polymorphism (blood cellular DNA) was identified as a biomarker of susceptibility. Further studies are planned to test the validity and feasibility of these biomarkers to detect either high exposure to crystalline silica and early silicosis or susceptibility to silicosis in gold miners in South Africa.

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Direct radioimmunoassay of angiotensin-converting enzyme in sera from patients with pulmonary diseases

Cited by 7 publications

References 26 publications

Poor Outcome and Mortality in Patients with Lower Lung-Dominant Sarcoidosis

Poor Outcome and Mortality in Patients with Lower Lung-Dominant Sarcoidosis

Focus on increased serum angiotensin-converting enzyme level: From granulomatous diseases to genetic mutations

Mechanistically Identified Suitable Biomarkers of Exposure, Effect, and Susceptibility for Silicosis and Coal-Worker'S Pneumoconiosis: A Comprehensive Review

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