Direct reductive amination of carbonyl compounds with primary/secondary amines using recyclable water-soluble FeII/EDTA complex as catalyst

Reduction Reactions in Green Solvents: Water, Supercritical Carbon Dioxide, and Ionic Liquids

“…Another eco-friendly method was reported by Bhanage and co-workers, [41] who developed a water soluble Fe II /EDTA-Na 2 complex as a catalyst with molecular hydrogen for the direct reductive amination of aliphatic, aromatic and heterocyclic carbonyl compounds with primary and secondary amines. This method is an excellent replacement for expensive noble metal catalysts or stoichiometric reducing agents.…”

Iron‐Catalyzed Hydrogenation, Hydride Transfer, and Hydrosilylation: An Alternative to Precious‐Metal Complexes?

“…[14] In iron chemistry, Bhanage and co-workers described the first reductive amination using a water-soluble Fe II / EDTA-Na 2 complex as catalyst under hydrogen pressure. [15] Even if the reaction conditions remained quite harsh, this simple catalyst appeared to be efficient and various substituted aryl and/or alkyl amines were isolated (Scheme 4).…”

Transfer hydrogenative reductive amination of aldehydes in aqueous sodium formate solution

“…Afterward, several groups have developed different methods of aqueous reductive amination based on either hydride reagents or hydrogenation using gaseous H 2 . [6][7][8][9][10][11] However, these reactions usually suffer some drawbacks, such as the requirement of high temperatures and moderate to high pressures, or poor atom economy. Xiao and co-workers [12][13][14][15][16] have pioneered in the catalytic transfer hydrogenation reactions in water.…”