Direct sampling of metastatic ovarian carcinoma masquerading as endocervical adenocarcinoma in liquid-based cytology cervical sample

Gupta, Nalini; Bhar, Vikrant Singh; Dey, Pranab; Rajwanshi, Arvind; Suri, Vanita

doi:10.4103/0970-9371.145654

Cited by 2 publications

(1 citation statement)

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“…The differential diagnosis of serous adenocarcinoma in the cervical smear includes squamous lesions (either invasive carcinoma or high-grade squamous intraepithelial lesion) because squamous cells occur individually or in clusters with tumor diathesis in the background [13]. Differential diagnosis can sometimes be very difficult if squamous intraepithelial neoplasia involves the endocervical glands.…”

Section: Discussionmentioning

confidence: 99%

Serous adenocarcinoma detected in the cervical smear: A case report

et al. 2020

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Introduction. Cytological smear tests of the cervix are routine diagnostic methods used for detection of precancerous lesions and tumors of the cervix; they are highly sensitive and specific in the detection of precancerous squamous intraepithelial lesions. Glandular lesions are much less frequently found in the cervical smear. The most common glandular lesions detected in the cervical smear are endocervical and endometrial adenocarcinomas. Cervical metastases are rare, although there are case reports in the literature. Case Report. In this case report, we present a 64-year-old woman with an abnormal cervical smear and postmenopausal metrorrhagia. Numerous accumulations, as well as individual atypical epithelial cells, were detected in the cervical smear and a cytological diagnosis of a highgrade squamous intraepithelial lesion was made based on cytomorphological features suspicious for invasion (Bethesda Classification, 2014) so a cervical biopsy and curettage of the endocervical canal were performed. A high-grade serous adenocarcinoma was diagnosed by histopathological examination of cervical biopsy and cervical canal curettage specimens, after which a transvaginal ultrasound examination was performed, which showed tumors on both ovaries and free fluid in the abdominal cavity. The patient underwent abdominal hysterectomy with bilateral salpingo-oophorectomy. Histological examination confirmed high-grade ovarian papillary serous adenocarcinoma with psammoma bodies. Conclusion. The cytological diagnostic features and criteria for serous adenocarcinoma in Papanicolaou smears are still vague and insufficiently defined in the literature, which is the reason for very common errors in the interpretation, so further research on the pathogenesis, diagnosis and therapy of this tumor is of great importance.

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Section: Discussionmentioning

confidence: 99%