Direct Synthesis of Monofunctionalized Indolizine Derivatives Bearing Alkoxymethyl Substituents at C‐3 and Their Benzofused Analogues.

Abstract

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Indolizine Studies, Part 5: Indolizine-2-carboxamides as Potential HIV-1 Protease Inhibitors[1]

“…Indolizine derivatives have been reported to exhibit valuable biological activity as potential calcium entry blockers, [8] cardiovascular agents, [8,9] anti-5-hydroxytryptamine, [10] antihistamine, [10] antitumor, [11] anti-Mycobacterium tuberculosis (TB), [12] anticancer, [8,13] and anti-HIV [8,14] agents. Various approaches have been developed for the synthesis of indolizine derivatives.…”